Phthalate exposure and semen quality in infertile male population from Tianjin, China: Associations and potential mediation by reproductive hormones

Wang, Bin; Qin, Xiaolei; Xiao, Nan; Yao, Yiming; Duan, Yanmin; Cui, Xianfeng; Zhang, Shuai; Luo, Haining; Sun, Hongwen

doi:10.1016/j.scitotenv.2020.140673

Cited by 36 publications

(12 citation statements)

References 89 publications

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“…In this study, 9 PAEs and 10 mPAEs were detected in the urine of 39 men in Tianjin, with the average detection rate exceeding 30.77%. The detection rate in this study was similar to that of 88 male volunteers in Tianjin, China (31.8%) (42), but lower than that of 84 primiparas in Shenzhen, China (73%) (8) and 84 male adults in Fujian, China (64.3%) (43). In this study, the most widely detected were MBP, MiBP, and MEHP (100%, respectively), higher than the detection frequency of the general population in Guangzhou, China (84.2, 46.3, and 60.4%, respectively) (44), and (2) Some factors, such as individual genetic susceptibility, could influence pollutant metabolism.…”

Section: Discussionsupporting

confidence: 85%

Phthalates and phthalate metabolites in urine from Tianjin and implications for platelet mitochondrial DNA methylation

Guo

Fang

et al. 2023

Front. Public Health

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BackgroundPhthalates (PAEs) are important synthetic substances in plastics, attracting much attention due to their potential effects on the cardiovascular system.MethodsIn this study, urine and blood samples from 39 individuals were collected in Tianjin, China. Phthalates and phthalate metabolites (mPAEs) were analyzed using gas chromatography-mass spectrometry (GC-MS) and high-performance liquid chromatography-mass spectrometry (HPLC-MS), respectively. The polymerase chain reaction (PCR) products from bisulfite-treated mitochondrial DNA (mtDNA) samples were analyzed using pyrosequencing technology.ResultsThe detection frequencies for 9 PAEs varied from 2.56 to 92.31%, and those for 10 mPAEs varied from 30.77 to 100%. The estimated daily intakes (EDIs) and cumulative risk of PAEs were calculated based on the experimental statistics of urinary PAEs and mPAEs. For PAEs, the HIRfD (hazard index corresponding to reference doses) values of 10.26% of participants and the HITDI (hazard index corresponding to tolerable daily intake) values of 30.77% of participants were estimated to exceed 1, suggesting a relatively high exposure risk. The mtDNA methylation levels in the MT-ATP8 and MT-ND5 were observed to be lower than in the MT-ATP6. Mono-ethyl phthalate (MEP) and MT-ATP8 were positively correlated with triglyceride levels (p < 0.05). Based on the association of PAEs, mtDNA methylation, and triglycerides, the mediating role of mtDNA methylation between PAEs and cardiovascular diseases (CVDs) was analyzed in this study, but no mediated effect was observed.ConclusionThe effects of PAE exposure on cardiovascular diseases (CVDs) should be investigated further.

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Section: Discussionsupporting

confidence: 85%

Phthalates and phthalate metabolites in urine from Tianjin and implications for platelet mitochondrial DNA methylation

Guo

Fang

et al. 2023

Front. Public Health

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“…For the other metabolites, the order of magnitude seems to be similar to those previously reported, albeit with some variability in values. Published values for urinary MBzP concentrations range from 0.2 to 22.0 µg/L, while MnBP levels range from 15.28 to 147 µg/L [55][56][57]59]. Our findings are quite similar in both cases, with 3.73 µg/g creatinine and 27.96 µg/g creatinine for MBzP and MnBP, respectively.…”

Section: Discussionsupporting

confidence: 75%

A Case–Control Study on the Effects of Plasticizers Exposure on Male Fertility

Caporossi

Viganò

Paci

et al. 2022

IJERPH

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Male infertility is a serious concern for public health, and the possible role of exposure to plasticizers such as phthalates and bisphenol A in contributing to the condition is widely debated. We have herein enrolled 155 infertility cases attending an infertility center and 211 controls (fathers of a spontaneously conceived newborn) to investigate this issue. The urinary levels of seven phthalates and BPA were analyzed through HPLC/MS/MS. All data were statistically elaborated considering information about clinical situation, life habits, occupational activity, and, for cases, semen parameters (volume, sperm concentration, total count of spermatozoa, and sperm motility). Results showed significantly higher urinary concentrations for all the phthalates in cases compared to controls, except for monoethylphthalate and BPA. In total, 90.07% of cases had sperm motility lower than the WHO reference value (2010), while 53.69%, 46.31%, and 16.56% had sperm total number, concentration, and volume, respectively, out of the reference range. Regarding the possible source of exposure, the use of scents seems to be a significant source of DEP (diethylphthalate). When considering occupational settings, industrial workers, dental technicians, artisans, and farmers using chemicals showed higher risk (OR = 2.766, 95% CI 1.236–6.185), particularly in relation to DnBP (di-n-butyl phthalate) and DEHP (di-ethyl-hexyl phthalate) exposure. No clear quantitative correlation between specific plasticizers and sperm parameters could be demonstrated but these findings call for future studies about the risks associated with exposure to their mixture.

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“…Even so, evidence of the association is rather convincing, such as that between phthalate metabolite levels and decreased sperm quality ( 114 , 115 ). Findings reported for general population are not as consistent.…”

Section: Phtalatesmentioning

confidence: 99%

Environmental and occupational exposures associated with male infertility

Marić

Fučić

Aghayanian

2021

Archives of Industrial Hygiene and Toxicology

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The upsurge in male infertility over the last two decades, possibly due to environmental exposure, has raised significant interest, particularly boosted by reports from fertility clinics, which showed that chronic diseases and hereditary or other medical conditions might only partially explain current incidence of male infertility. Both environmental and occupational settings may have a significant role in exposure to complex mixtures of endocrine disruptors (ED), which play a major role in fertility disorders. The aim of this review is to give an insight into the current knowledge on exposure settings which may be associated with male infertility. Our study relied on a systematic search of PubMed, Scopus, and Web of Science for articles published between January 2000 and September 2020. It showed that some well documented factors associated with male infertility include smoking, and physiological disturbances or chronic diseases such as obesity and diabetes, which in turn, may also reflect lifestyle choices and environmental exposures, especially to EDs such as phthalates, bisphenols, pesticides, and flame retardants. However, the number of studies on the aetiology of male infertility is still too low in comparison with the size of affected population. Occupational health follow-ups and medical surveillance do not collect any data on male infertility, even though ED chemicals are part of many technological processes.

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Phthalate exposure and semen quality in infertile male population from Tianjin, China: Associations and potential mediation by reproductive hormones

Cited by 36 publications

References 89 publications

Phthalates and phthalate metabolites in urine from Tianjin and implications for platelet mitochondrial DNA methylation

Phthalates and phthalate metabolites in urine from Tianjin and implications for platelet mitochondrial DNA methylation

A Case–Control Study on the Effects of Plasticizers Exposure on Male Fertility

Environmental and occupational exposures associated with male infertility

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