Phthalates and Phthalate Alternatives Have Diverse Associations with Oxidative Stress and Inflammation in Pregnant Women

Erve, Thomas J. van ‘t; Rosen, Emma M.; Barrett, Emily S.; Nguyen, Ruby H.N.; Sathyanarayana, Sheela; Milne, Ginger L.; Calafat, Antònia M.; Swan, Shanna H.; Ferguson, Kelly K.

doi:10.1021/acs.est.8b05729

Cited by 104 publications

(42 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 37 Likewise, although health effects of DINCH are largely unstudied, urinary DINCH metabolite concentrations have been related to poorer markers of ovarian response among a population of predominantly White women undergoing fertility treatment at a Massachusetts hospital 38 and increased inflammation in racially-diverse cohort of pregnant women recruited from four academic medical centers across the United States. 39 These results have implications for racial disparities in health outcomes.…”

Section: Introductionmentioning

confidence: 99%

Correlates of urinary concentrations of phthalate and phthalate alternative metabolites among reproductive-aged Black women from Detroit, Michigan

Wesselink

Fruh

Hauser

et al. 2020

J Expo Sci Environ Epidemiol

Self Cite

View full text Add to dashboard Cite

Background: Phthalates are endocrine-disrupting chemicals that are widely present in consumer products. In the United States, Black women are more highly exposed to phthalates than other racial/ethnic groups, yet information on predictors of phthalate exposure among Black women is limited. Objective: We evaluated the association of demographics, lifestyle, reproductive history, and personal care product use with urinary concentrations of phthalate and phthalate alternative metabolites, using cross-sectional data from 754 Black women from Detroit, Michigan (2010–2012). Methods: Women completed questionnaires and provided urine specimens which were analyzed for 16 phthalate and phthalate alternative metabolites. We used linear regression models to estimate mean percentage differences and 95% confidence intervals (CIs) in concentrations across levels of correlates. Results: Monoethyl (MEP) and mono-n-butyl phthalate concentrations were positively associated with personal care product use, particularly nail products. Educational attainment was positively associated with high molecular weight phthalate concentrations but inversely associated with monobenzyl phthalate (MBzP) concentrations. Parity was positively associated with MBzP concentrations and inversely associated with concentrations of MEP and high molecular weight phthalates. Significance: We found that sociodemographics, reproductive characteristics, and use of certain personal care products were associated with urinary phthalate concentrations among Black women. Our results emphasize the importance of examining exposure determinants among multiply-marginalized populations.

show abstract

Section: Introductionmentioning

confidence: 99%

Correlates of urinary concentrations of phthalate and phthalate alternative metabolites among reproductive-aged Black women from Detroit, Michigan

Wesselink

Fruh

Hauser

et al. 2020

J Expo Sci Environ Epidemiol

Self Cite

View full text Add to dashboard Cite

show abstract

“…Despite remaining unknown, several hypotheses have been put forward for the mechanism of increased BP in pregnancy due to exposure to phthalates, including the increase in oxidative stress, which could lead to the release of angiogenic factors [ 65 ]; the decrease in serum thyroxin [ 66 ], and the increase of inflammatory cytokines [ 67 ]. All these may be important factors for gestational hypertension or preeclampsia development [ 64 , 68 , 69 , 70 ].…”

Section: Human Studiesmentioning

confidence: 99%

Phthalates Implications in the Cardiovascular System

Mariana

Cairrão

2020

JCDD

View full text Add to dashboard Cite

Today’s sedentary lifestyle and eating habits have been implicated as some of the causes of the increased incidence of several diseases, including cancer and cardiovascular diseases. However, environmental pollutants have also been identified as another possible cause for this increase in recent decades. The constant human exposure to plastics has been raising attention regarding human health, particularly when it comes to phthalates. These are plasticizers used in the manufacture of industrial and consumer products, such as PVC (Polyvinyl Chloride) plastics and personal care products, with endocrine-disrupting properties, as they can bind molecular targets in the body and interfere with hormonal function. Since these compounds are not covalently bound to the plastic, they are easily released into the environment during their manufacture, use, or disposal, leading to increased human exposure and enhancing health risks. In fact, some studies have related phthalate exposure with cardiovascular health, having already shown a positive association with the development of hypertension and atherosclerosis in adults and some cardiometabolic risk factors in children and adolescents. Therefore, the main purpose of this review is to present and relate the most recent studies concerning the implications of phthalates effects on the cardiovascular system.

show abstract

“…Little information is available about the association between phthalates and inflammation. The few studies that do exist [65][66][67] do not suggest how it might affect reproductive development in male offspring. More recently, several authors reported that exposure of neonatal mice to BPA can disrupt pituitary development, with critical effects on their pubertal and hence gonadal development.…”

Section: Postnatal Exposure: Are There Repercussions For Adult Testicmentioning

confidence: 99%

Mechanisms of Testicular Disruption from Exposure to Bisphenol A and Phtalates

Pallotti

Pelloni

Gianfrilli

et al. 2020

JCM

View full text Add to dashboard Cite

Great attention has been paid in recent years to the harmful effects of various chemicals that interfere with our natural hormone balance, collectively known as endocrine-disrupting chemicals (EDCs) or endocrine disruptors. The effects on the reproductive system of bisphenol A (BPA) and phthalates have received particular attention: while they have a short half-life, they are so widespread that human exposure can be considered as continuous. Evidence is often limited to the animal model, disregarding the likelihood of human exposure to a mixture of contaminants. Data from animal models show that maternal exposure probably has harmful effects on the male fetus, with an increased risk of urogenital developmental abnormalities. After birth, exposure is associated with changes in the hypothalamic-pituitary-testicular axis, hindering the development and function of the male genital pathways through the mediation of inflammatory mechanisms and oxidative stress. The epidemiological and clinical evidence, while generally confirming the association between reproductive abnormalities and some phthalate esters and BPA, is more contradictory, with wildly different findings. The aim of this review is therefore to provide an update of the potential mechanisms of the damage caused by BPA and phthalates to reproductive function and a review of the clinical evidence currently available in the literature.

show abstract

Phthalates and Phthalate Alternatives Have Diverse Associations with Oxidative Stress and Inflammation in Pregnant Women

Abstract: Exposure to environmental chemicals such as phthalates has been linked to numerous adverse pregnancy outcomes, potentially through an oxidative stress mediated mechanism. Most research *

Cited by 104 publications

References 40 publications

Correlates of urinary concentrations of phthalate and phthalate alternative metabolites among reproductive-aged Black women from Detroit, Michigan

Correlates of urinary concentrations of phthalate and phthalate alternative metabolites among reproductive-aged Black women from Detroit, Michigan

Phthalates Implications in the Cardiovascular System

Mechanisms of Testicular Disruption from Exposure to Bisphenol A and Phtalates

Contact Info

Product

Resources

About