Phthalates promote prostate cancer cell proliferation through activation of ERK5 and p38

Zhu, Mingming; Huang, Cong; Ma, Xiao; Wu, Rui; Zhu, Wenzhen; Li, Xiaoting; Liang, Zhaofeng; Deng, Feifei; Wu, Jieshu; Geng, Shanshan; Xie, Chunfeng; Zhong, Caiyun

doi:10.1016/j.etap.2018.08.007

Cited by 59 publications

(33 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Phthalates have been extensively correlated to several human cancer, i.e., skin, liver, prostate, and breast cancer [ 95 , 96 , 97 ]. Noteworthy, PAEs (i.e., BBP and DEHP) would increase the expression of vascular endothelium growth factor (VEGF) and, consequently, angiogenesis and tumor progression in breast cancer cells [ 98 ].…”

Section: Toxicological Aspects and Human Health Effectsmentioning

confidence: 99%

“…Noteworthy, several PAEs (i.e., DEHP, BBP, and DBP) are suspected to interfere with cell cycle-related genes responsible for prostate cancer cell proliferation [ 97 ]. Indeed, PAEs would promote the growth of PC3 and 22RV1 prostate cancer cells via up-regulation of MAPK, c-fos, and c-Jun, three proteins involved in AP1-mediated cell proliferation.…”

Section: Toxicological Aspects and Human Health Effectsmentioning

confidence: 99%

See 1 more Smart Citation

Critical Review on the Presence of Phthalates in Food and Evidence of Their Biological Impact

Giuliani

Zuccarini

Cichelli

et al. 2020

IJERPH

249

119

View full text Add to dashboard Cite

Phthalates are a huge class of chemicals with a wide spectrum of industrial uses, from the manufacture of plastics to food contact applications, children’s toys, and medical devices. People and animals can be exposed through different routes (i.e., ingestion, inhalation, dermal, or iatrogenic exposure), as these compounds can be easily released from plastics to water, food, soil, air, making them ubiquitous environmental contaminants. In the last decades, phthalates and their metabolites have proven to be of concern, particularly in products for pregnant women or children. Moreover, many authors reported high concentrations of phthalates in soft drinks, mineral waters, wine, oil, ready-to-eat meals, and other products, as a possible consequence of their accumulation along the food production chain and their accidental release from packaging materials. However, due to their different physical and chemical properties, phthalates do not have the same human and environmental impacts and their association to several human diseases is still under debate. In this review we provide an overview of phthalate toxicity, pointing out the health and legal issues related to their occurrence in several types of food and beverage.

show abstract

Section: Toxicological Aspects and Human Health Effectsmentioning

confidence: 99%

Section: Toxicological Aspects and Human Health Effectsmentioning

confidence: 99%

Critical Review on the Presence of Phthalates in Food and Evidence of Their Biological Impact

Giuliani

Zuccarini

Cichelli

et al. 2020

IJERPH

249

119

View full text Add to dashboard Cite

show abstract

“…Phthalates, acting like anti-androgens, disrupt the hormonal balance between estradiol and testosterone, leading to abnormal prostate cell proliferation [ 107 , 108 ]. An in vitro study demonstrated the stimulatory effect of phthalates DEHP (at 10 −4 –10 −6 mol/L), BBzP and DBP (at 10 −6 –10 −7 mol/L) on the proliferation of PC-3 human prostatic carcinoma cells [ 109 ]. The same study reported the stimulatory effect of DEHP, BBzP (at 10 −7 –10 −10 mol/L) and DBP (10 −8 –10 −10 mol/L) on the proliferation of 22RV1 human prostatic carcinoma cells [ 109 ].…”

Section: Phthalates’ Action On Male Reproductive Healthmentioning

confidence: 99%

“…An in vitro study demonstrated the stimulatory effect of phthalates DEHP (at 10 −4 –10 −6 mol/L), BBzP and DBP (at 10 −6 –10 −7 mol/L) on the proliferation of PC-3 human prostatic carcinoma cells [ 109 ]. The same study reported the stimulatory effect of DEHP, BBzP (at 10 −7 –10 −10 mol/L) and DBP (10 −8 –10 −10 mol/L) on the proliferation of 22RV1 human prostatic carcinoma cells [ 109 ]. Zhu et al [ 110 ] showed a positive association between the exposure to BBzP at 10 −6 –10 −7 mol/L and the proliferation of LNCaP and PC-3 human prostatic carcinoma cells.…”

Section: Phthalates’ Action On Male Reproductive Healthmentioning

confidence: 99%

Effects and Mechanisms of Phthalates’ Action on Reproductive Processes and Reproductive Health: A Literature Review

Hlisníková

Petrovičová

Kolena

et al. 2020

IJERPH

164

View full text Add to dashboard Cite

The production of plastic products, which requires phthalate plasticizers, has resulted in the problems for human health, especially that of reproductive health. Phthalate exposure can induce reproductive disorders at various regulatory levels. The aim of this review was to compile the evidence concerning the association between phthalates and reproductive diseases, phthalates-induced reproductive disorders, and their possible endocrine and intracellular mechanisms. Phthalates may induce alterations in puberty, the development of testicular dysgenesis syndrome, cancer, and fertility disorders in both males and females. At the hormonal level, phthalates can modify the release of hypothalamic, pituitary, and peripheral hormones. At the intracellular level, phthalates can interfere with nuclear receptors, membrane receptors, intracellular signaling pathways, and modulate gene expression associated with reproduction. To understand and to treat the adverse effects of phthalates on human health, it is essential to expand the current knowledge concerning their mechanism of action in the organism.

show abstract

“…BBP has been viewed as a potent phthalate expressing estrogenic‐like activities through estrogen receptors (ERs), whereas its intensity is supposed to be very weak compared with estradiol (17β‐estradiol [E 2 ]; Ghisari & Bonefeld‐Jorgensen, ; Picard et al, ). Recent research has found that low doses of BBP stimulated the proliferation of prostate cancer PC‐3 and 22RV1 cell lines, and induced cell growth of prostate cancer (M. M. Zhu et al, ). Another study revealed that low‐dose BBP could induce additive antiapoptotic and proliferative effects in the presence of E 2 (F. P. Chen & Chien, ).…”

Section: Introductionmentioning

confidence: 99%

Growth‐promoting effects of low‐level butyl benzyl phthalate exposure on human neuroblastoma SH‐SY5Y cells

Zhang

Shi

et al. 2019

J of Applied Toxicology

View full text Add to dashboard Cite

The purpose of present study was to investigate the impact of butyl benzyl phthalate (BBP) on SH-SY5Y neuroblastoma cells in vitro. The cell counting kit-8 was used to measure cell proliferation and flow cytometry was utilized to study cell cycle phases and apoptosis. Western blotting and quantitative real-time polymerase chain reaction were used to detect levels of aromatase, estrogen receptors (ERs) and some apoptosis and cell cycle-related genes. Results showed BBP-stimulated SH-SY5Y cells in a dose-dependent manner and produced a reverted U-shaped dose-response curve. BBP at lower concentrations (0.01 and 0.1 μM) significantly induced cell proliferation while inhibited cell growth at 300 μM. The promoting effect of estradiol could be entirely blocked by administration of ICI182 780, a pure antagonist of ERs, while the effect of BBP could be partly blocked. Additionally, we confirmed 0.1 μM BBPinduced cell proliferation caused the arrest of cells in S phase and inhibited apoptosis, which might be partially explained by the decreased expression of p53, the increased expression of proliferating cell nuclear antigen, Bcl-2 and cell cycle regulator cyclin-D1, and the activation of aromatase. The addition of ICI182 780 had no effect on BBP-induced ERβ mRNA expression, whereas ICI182 780 could effectively counteract the effect of estradiol. Moreover, pretreatment with ICI182 780 could block the induction of aromatase protein expression and activity by BBP, showing an involvement of ERs. Except for the ER pathway, these results showed there might be other pathways involved in promoting the effects of low-level BBP on SH-SY5Y cells, which require further investigation.

show abstract

Phthalates promote prostate cancer cell proliferation through activation of ERK5 and p38

Cited by 59 publications

References 22 publications

Critical Review on the Presence of Phthalates in Food and Evidence of Their Biological Impact

Critical Review on the Presence of Phthalates in Food and Evidence of Their Biological Impact

Effects and Mechanisms of Phthalates’ Action on Reproductive Processes and Reproductive Health: A Literature Review

Growth‐promoting effects of low‐level butyl benzyl phthalate exposure on human neuroblastoma SH‐SY5Y cells

Contact Info

Product

Resources

About