Phthalocyanine‐Assembled Nanodots as Photosensitizers for Highly Efficient Type I Photoreactions in Photodynamic Therapy

Abstract

Owing to their unique,n anoscale related optical properties,n anostructures assembled from molecular photosensitizers (PSs) have interesting applications in phototheranostics.H owever,m ost nanostructured PS assemblies are super-quenched, thus,p reventing their use in photodynamic therapy( PDT). Although some of these materials undergo stimuli-responsive disassembly,which leads to partial recovery of PDT activity,t heir therapeutic potentials are unsatisfactory owingt oalimited ability to promote generation reactive oxygen species (ROS), especially via type Ip hotoreactions (i.e., not by 1 O 2 generation). Herein we demonstrate that anew, nanostructured phthalocyanine assembly,N anoPcA, has the ability to promote highly efficient ROSg eneration via the type Im echanism. The results of antibacterial studies demonstrate that NanoPcA has potential PDT applications.

A facile fabrication of novel stuff with antibacterial property and osteogenic promotion utilizing red phosphorus and near-infrared light

“…However, this quite excessive temperature can disrupt nature tissues and lead to other diseases or problems [ 7 , 8 ]. A mass of works have confirmed that reactive oxygen species (ROS) such as 1 O 2 can kill bacteria by destroying its protein or DNA [ [9] , [10] , [11] ]. By combining photosensitizer, a relevant light can stimulate material to produce ROS and kill bacteria.…”

High‐Fidelity Trapping of Spatial–Temporal Mitochondria with Rational Design of Aggregation‐Induced Emission Probes

“…Since targeting mitochondria has emerged as a new strategy for improved therapeutic efficiency, the AIE‐based strategy might provide a new platform for image‐guided phototherapy with the assistance of mitochondrial‐targeted imaging . That is, the enrichment of AIEgen probes in cancer cell mitochondria is expected to effectively kill tumor cells with significantly light‐induced intracellular reactive oxygen species (ROS) generation.…”

Exfoliation and Sensitization of 2D Carbon Nitride for Photoelectrochemical Biosensing under Red Light

“…However, due to the limitation of TsCuPc, red light (l > 630 nm) was used in this work. As metallophthalocyanines have been widely used for in vivo applications such as photodynamic therapy, [16] we envision that further investigation by using as imilar principle would make the CNNS-metallophthalocyanine system suitable for NIR. In addition, owing to the lack of suitable photoactive materials,v ery few works regarding PEC biosensing with red light have been reported, such as using TiO 2 /CdTe/NaYF 4 :Yb/Er,Z nO nanorods/naphthalocyanine, TiO 2 nanotube photonic crystals, Ag NPs/Ag 2 SQ Ds, and Ag 2 S/ NaYF 4 :Yb/Er.…”

“…In photosynthesis by plants, which converts solar energy to biomass and providese nergy for humans, porphyrin systems play an irreplaceabler ole. [15] Among them, metallophthalocyanines (MPcs), whichc ontain alternating C=Ca nd C=Nb onds, lead to excellent harvesting of red and near-infrared light of the solar spectrum for wide applications,f or example, organic solar cells, photodynamic cancer therapy, [16] heat absorbers, gas sensors, [17] and bioimaging. [18] Given the unique characteristic of MPcs, coupling of molecular MPc antennas on semicon-ductingC Nb yp-p stacking interaction is ar easonable solution to address the above difficulties; however,s ensitized CN responsive to long-wavelengthl ight for PEC biosensing has not been explored, and only very limited work regarding successful PECb iosensingu nder long-wavelength light has been reported so far.…”