Phycocyanin as a nature-inspired antidiabetic agent: A systematic review

Ziyaei, Kobra; Abdi, Fatemeh; Mokhtari, Majid; Daneshmehr, Mohammad Ali; Ataie, Zahra

doi:10.1016/j.phymed.2023.154964

Cited by 17 publications

(4 citation statements)

References 72 publications

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“…Spirulina is not only rich in PC but is a rich source of other bioactive compounds, including proteins, polysaccharides, polyunsaturated fatty acids, vitamins, and carotenoids [175][176][177]. Different studies have demonstrated the neuroprotective role of Spirulina on the development of the neural system, senility, and a number of pathological conditions, including neurological and neurodegenerative diseases [178][179][180][181].…”

Section: Phycocyanin and Spirulina Extractmentioning

confidence: 99%

Exploiting Natural Niches with Neuroprotective Properties: A Comprehensive Review

Moukham,

Lambiase,

Barone

et al. 2024

Nutrients

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Natural products from mushrooms, plants, microalgae, and cyanobacteria have been intensively explored and studied for their preventive or therapeutic potential. Among age-related pathologies, neurodegenerative diseases (such as Alzheimer’s and Parkinson’s diseases) represent a worldwide health and social problem. Since several pathological mechanisms are associated with neurodegeneration, promising strategies against neurodegenerative diseases are aimed to target multiple processes. These approaches usually avoid premature cell death and the loss of function of damaged neurons. This review focuses attention on the preventive and therapeutic potential of several compounds derived from natural sources, which could be exploited for their neuroprotective effect. Curcumin, resveratrol, ergothioneine, and phycocyanin are presented as examples of successful approaches, with a special focus on possible strategies to improve their delivery to the brain.

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Section: Phycocyanin and Spirulina Extractmentioning

confidence: 99%

Exploiting Natural Niches with Neuroprotective Properties: A Comprehensive Review

Moukham,

Lambiase,

Barone

et al. 2024

Nutrients

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“…In a recent review, Ziyaei and collaborators [ 75 ], in examining the molecular mechanisms involved in the anti-diabetic effects described for C-PC, suggested that a reduction in β-cell apoptosis, an improvement of their function, and a regulation of the hepatic glucose metabolism were the main mechanisms involved in C-PC activity.…”

Section: Health Promoting Effectsmentioning

confidence: 99%

Nutraceutical Features of the Phycobiliprotein C-Phycocyanin: Evidence from Arthrospira platensis (Spirulina)

Citi,

Torre,

Flori

et al. 2024

Nutrients

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Arthrospira platensis, commonly known as Spirulina, is a photosynthetic filamentous cyanobacterium (blue–green microalga) that has been utilized as a food source since ancient times. More recently, it has gained significant popularity as a dietary supplement due to its rich content of micro- and macro-nutrients. Of particular interest is a water soluble phycobiliprotein derived from Spirulina known as phycocyanin C (C-PC), which stands out as the most abundant protein in this cyanobacterium. C-PC is a fluorescent protein, with its chromophore represented by the tetrapyrrole molecule phycocyanobilin B (PCB-B). While C-PC is commonly employed in food for its coloring properties, it also serves as the molecular basis for numerous nutraceutical features associated with Spirulina. Indeed, the comprehensive C-PC, and to some extent, the isolated PCB-B, has been linked to various health-promoting effects. These benefits encompass conditions triggered by oxidative stress, inflammation, and other pathological conditions. The present review focuses on the bio-pharmacological properties of these molecules, positioning them as promising agents for potential new applications in the expanding nutraceutical market.

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“…For example, phycocyanin is a protein compound that has anti-diabetes properties. The mechanism of action is as follows: 96 1. preventing β-cell dysfunction induced by human islet amyloid polypeptides and methylglyoxal; 2. inducing apoptosis by activating Nrf2 and PI3K/Akt, and inhibiting JNK and p38; and 3. regulating hepatic sugar metabolism.…”

Section: Applications In Medicinementioning

confidence: 99%