Phylogenetic analysis and haplotype diversity in Christian residents of Lahore, Pakistan, using 17 Y-chromosomal STR loci

Saleem, Samia; Shahid, Ahmad Ali; Shafique, Muhammad; Rubab, Aqsa; Javed, Faqeeha; Husnain, Tayyab

doi:10.1007/s00414-019-02030-3

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“…Other Pakistani Populations were distantly associated like Sindhi grouped with North Indian Balmiki; Balochi and Yousafzai Pathan shared genetic association to Caucasian, Uganda and African American. Similarly, a neighbour joining tree was constructed using our published 17-YSTRs data 9 of studied population and 16 reference populations based upon R ST p-values. Pairwise R ST p-values were calculated through AMOVA using online YHRD tool.…”

Section: Resultsmentioning

confidence: 99%

“…We emphasize that this population must be targeted as a whole, to understand the genetic context of Christians and its connection to the greater Eurasian continent. Hence, Lahore-Christian samples were evaluated based on fifteen autosomal STRs of Identifiler Plus Kit (Applied Biosystems) and already published data set of same male samples (YA004381) 9 on 17 YSTRs (DYS438, DYS393, DYS385a⁄b, DYS389I⁄II, DYS458, DYS437, DYS391, DYS392, DYS635 (Y-GATA-C4), Y-GATA-H4, DYS19, DYS390, DYS439, DYS456, DYS448). To affirm phylogenetic affiliations of this population, data sets were compared with referenced populations as given in Table 1 .…”

Section: Introductionmentioning

confidence: 99%

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Population genetic portrait of Pakistani Lahore-Christians based on 32 STR loci

Rubab

Shafique

Javed

et al. 2020

Sci Rep

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Phylogenetic relationship and the population structure of 500 individuals from the Christian community of Lahore, Pakistan, were examined based on 15 autosomal short tandem repeats (STRs) using the AmpFℓSTR Identifiler Plus PCR Amplification Kit and our previously published Y-filer kit data (17 Y-STRs) of same samples. A total of 147 alleles were observed in 15 loci and allele 11 at the TPOX locus was the most frequent with frequency value (0.464). The data revealed that the Christian population has unique genetic characteristics with respect to a few unusual alleles and their frequencies relative to the other Pakistani population. Significant deviations from Hardy–Weinberg equilibrium were found at two loci (D13S317, D18S51) after Boneferroni’s correction (p ≤ 0.003). The combined power of discrimination, combined power of exclusion and cumulative probability of matching were 0.999999999999999978430815060354, 0.999995039393942 and 2.15692 × 10−17, respectively. On the bases of genetic distances, PCA, phylogenetic and structure analysis Lahore-Christians appeared genetically more associated to south Asian particularly Indian populations like Tamil, Karnataka, Kerala and Andhra Pradesh than rest of global populations.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%