Phylogenetic Analysis of Chikungunya Virus Strains Circulating in the Western Hemisphere

Lanciotti, Robert S.; Lambert, Amy J.

doi:10.4269/ajtmh.15-0375

Cited by 30 publications

(29 citation statements)

References 10 publications

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“…In addition, two newly isolated strains from man, Rio-U1 and Rio-S1, were also included. The phylogenetic tree clearly confirmed two previously known ZIKV lineages, African and Asian, and the Asian lineage origin of the recent ZIKV (Lanciotti and Lambert, 2016). The earliest recorded strain in the Asian lineage, P6-740 (Malaysia/1966), is a mosquito isolate, while all others are human isolates.…”

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confidence: 76%

Understanding the pathogenic evolution of Zika virus

Qin

2016

Sci. China Life Sci.

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Unlike the previous circulating strains that were not associated with significant human pathology, recent circulating Zika virus (ZIKV) strains isolated during the 2015-2016 Brazilian Outbreak are highly suspected to cause neuropathology, including disorders of fetal brain development and Guillain-Barré syndrome (Broutet et al., 2016). Studies have revealed that recent ZIKV strains can be spread through maternal-fetal (Calvet et al., 2016) and sexual (Hills et al., 2016) transmission, in addition to the traditional route of infection via mosquitoes. The unusual characteristics of the recent ZIKV have raised concern globally and necessitated molecular investigation. However, a clear understanding of the molecular evolution and mechanistic basis of increased pathogenicity of the recent ZIKV remains elusive.

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confidence: 76%

Understanding the pathogenic evolution of Zika virus

Qin

2016

Sci. China Life Sci.

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“…Currently in the Americas, transmission of the Asian genotype CHIKV [7–9] and East-Central-South African (ECSA) genotype [10] has been reported. According to reports of suspected and confirmed cases of CHIKV in America, the Pan American Health Organization [11] reported more than one million cases in the year 2014.…”

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confidence: 99%

Epidemic outbreak of Chikungunya in two neighboring towns in the Colombian Caribbean: a survival analysis

et al. 2017

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BackgroundThe first autochthonous Chikungunya virus transmission in Colombia was reported in September 2014. Three months later, every town in the Caribbean region was affected, including the bordering towns of Ovejas and Corozal, in the department of Sucre. The objective of the study was to analyze and compare the temporal dynamics of the outbreak of Chikungunya in two towns of the department of Sucre.MethodsHouseholds with suspicious cases with clinical symptomatology for Chikungunya were enrolled. In each house an epidemiological questionnaire was applied to collect economic and social information and methods for vector control.ResultsThe study analyzed data collected between 09/01/2014 and 01/31/2015; 458 families in Corozal and 516 families in Ovejas were identified with Chikungunya cases. Estimated attack rates were 10,621 cases and 1640 cases per 100,000 inhabitants, in Ovejas and Corozal, respectively. The 75-day survival curve was 27.2% lower (0.632, CI = 0.614–0.651) in Ovejas than in Corozal (0.904, CI = 0.891–0.917). After 120 days, both curves showed a stable horizontal slope, close to a survival probability of 0.54, indicating the end of the epidemic period. The log-rank test (X 2 = 94.6, 1fd, p-value = 0.000) showed the improved survival of Chikungunya in the town of Corozal. The relative risk between the two towns was 0.863 (CI = 0.809–0.921; p-value < 0.001).ConclusionsThe dynamics of the temporal distribution of CHIKV could be influenced by socioeconomic and preventable risk factors. Poor socioeconomic conditions such as the lack and poor efficiency of water supply and waste collection services could be determining factors in the proliferation of CHIKV. The survival analysis proved to be a suitable method for studying the presentation of CHIKV and can be applied to other prevalent vector-borne diseases such as the ZIKA and Dengue.

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“…The resulting single polyprotein is cleaved into the structural proteins capsid (C), pre-membrane precursor (prM), and envelope (E), and the non-structural proteins NS1, NS2A, NS2B, NS3, NS4A, 2K, NS4B, and NS5 (Kuno and Chang, 2007). Prior genetic and phylogenetic analyses have identified two main ZIKV lineages: African and Asian, and the recent 21 st century epidemics have been traced to the Asian lineage (Faye et al, 2014; Haddow et al, 2012; Lanciotti and Lambert, 2016). Despite circulating throughout Africa and Asia for the latter half of the 20 th century, ZIKV infections were not associated with significant human pathology until now.…”

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confidence: 99%