“…Based on previous studies, the genetic variation in L1 gene significantly affects the viral assembly, protein structure/confirmation results into altered biological functions and host immunogenic recognition with clinical significance (El-Aliani et al, 2017). The information about genetic diversity of HPV16 and HPV18 genotypes have been published in many reports worldwide (Shen et al, 2013, Assoumou et al, 2015, King et al, 2016, Nicolas-Parraga et al, 2016, Doorslaer et al, 2017, Islam et al, 2018, Van der Weele et al, 2018, Liu et al, 2018, Xu et al, 2018, Aziz et al, 2018, Tao et al, 2018, Ramas et al, 2018, Yoon et al, 2018). The current status of HPVs prevalence in Saudi Arabia has been published in many reports, but data on genetic diversity and evolutionary history in Saudi Arabia are lacking (Bondagji et al, 2013, Turki et al, 2013, Alsbeih et al, 2013, Alsbeih, 2014, Al-Ahdal et al, 2014, Al Obaid et al, 2014, Omran and AlSheeha, 2015, Alhamlan et al, 2015, Hussain et al, 2016, Ahmed et al, 2017a, Ahmed et al, 2017b).…”