Phylogenetic and Chemical Analyses of the Medicinal Plant Salvia circinnata: an Approach to Understand Metabolomics Differences

Sepúlveda-Cuellar, Laura; Duque-Ortiz, Arianna; Yáñez-Espinosa, Laura; Calzada, Fernando; Bautista, Elihú; Pastor-Palacios, Guillermo; Bedolla-García, Brenda Y.; Flores, Joel; Badano, Ernesto I.; Douterlungne, David

doi:10.1007/s43450-021-00168-z

Cited by 4 publications

(2 citation statements)

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“…The final temperature was maintained for 9 min. Each analysis was repeated in triplicate, and the volatile compounds were identified by deconvolution, using the W10N11 database (Wiley10Nist11) and the % area normalized (Sepúlveda-Cuellar et al 2021).…”

Section: Identification Of the Volatile Constituents By Gc-msmentioning

confidence: 99%

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Chemical constituents of Salvia urica Epling, and their antihyperglycemic and antipropulsive effects

García-Nava,

Valdes,

Calzada

et al. 2023

Bot. Sci.

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Background: Salvia urica Epling is taxonomically and phylogenetically related to Salvia amarissima Ortega. The last species has pharmacological relevance by its contents of bioactive metabolites. Nowadays, Salvia urica has no reports about its chemical constituents and pharmacological activities. Hypothesis: Does the close relationship between S. amarissima and S. urica led both species produce similar specialized metabolites? Does Salvia urica display similar pharmacological effects as S. amarissima? Studied species: Salvia urica Epling (Lamiaceae). Study site and dates: The plant material was collected in Teopisca, Chiapas, Mexico, in December 2021. Methods: Metabolites of the acetone extract from Salvia urica were identified by GC-MS and HPLC-PDA profiling. In parallel, a phytochemical study was conducted, and the individual purified constituents, previously characterized by 1D NMR, were assayed on antihyperglycemic effect in diabetic mice and a charcoal-gum arabic-induced hyperperistalsis model in rats. Results: The volatile compounds identified by GC-MS were alkanes, aromatics and triterpenes. The principal constituents of the acetone extract of Salvia urica were amarissinin A and 5,6-dihydroxy-7,3',4'-trimethoxyflavone, which were also quantified by HPLC-PDA. The extract and both metabolites isolated showed an antihyperglycemic effect on streptozotocin-induced diabetic mice, suggesting a possible synergic effect. In addition, the compound 5,6-dihydroxy-7,3',4'-trimethoxyflavone (IC50 = 0.79 mg/kg) showed a better antipropulsive effect than loperamide (IC50 = 16.6 mg/kg). Conclusions: The phytochemical composition of an acetone extract of Salvia urica was determined by first time. The metabolites isolated from this plant support the phylogenetic relationship of S. urica with Salvia amarissima, and they showed antipropulsive and antihyperglycemic effects.

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Section: Identification Of the Volatile Constituents By Gc-msmentioning

confidence: 99%

“…The PDA detector acquires the chromatograms at 240 and 330 nm, and the FL detector operates with an excitation longwave of 250 nm, and an emission longwave of 410 nm. All experiments were repeated in triplicate according to Sepúlveda-Cuellar et al (2021).…”

Section: Identification Of the Volatile Constituents By Gc-msmentioning

confidence: 99%