Phylogenetic characterization of porcine circovirus type 2 in PMWS and PDNS Korean pigs between 1999 and 2006

An, Dong-Jun; Roh, In-Soon; Song, Daesub; Park, Choi‐Kyu; Park, Bong‐Kyun

doi:10.1016/j.virusres.2007.06.024

Cited by 69 publications

(51 citation statements)

References 28 publications

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“…In addition, there has been a major shift from group 2 PCV2 to group 1 PCV2 in Korea and other countries. In contrast to the recent report on the epidemiology of PCV2 infection in Korean pigs from 2005 and 2006 [6], subgroups 1C and 2E PCV2 were also detected during 2005-2006 albeit in a small number of cases. This indicates that subgroups 1C and 2E PCV2 are still circulating in Korea.…”

contrasting

confidence: 99%

“…The comparison of nucleotide and amino acid sequences of the ORF2 gene between the Korean and other PCV2, which are known to be hypervariable and to be suitable phylogenetic marker [7,13,18,19], supported immediately above results (data not shown). Our results are consistent with those reported in the literature [6,11,23], in which group 1 PCV2 have become the dominant strains particularly subgroup 1A/B. In addition, there has been a major shift from group 2 PCV2 to group 1 PCV2 in Korea and other countries.…”

supporting

confidence: 93%

“…Since the subgroups of PCV2 circulating in Korean pigs have been reported to be 1A/B, 1C and 2E [6], the above result suggests that subgroup 2D PCV2 has newly emerged in Korea (Fig. 1).…”

mentioning

confidence: 77%

“…A recent study reported a shift in PCV2 from group 2 to group 1 and the disappearance of the subgroups 1C and 2E in Korean pigs between 1999-2006 [6]. However, the precise current status of PCV2 infections is unclear because the previous study used only 16 PCV2-positive samples of pigs with PMWS during 2005-2006 [6]. Therefore, this study examined the groups of PCV2 recently circulating in Korean pigs with PMWS.…”

mentioning

confidence: 97%

“…To date, PMWS is one of the most important diseases and causes considerable economic losses in pig producing industry in Korea [15]. A recent study reported a shift in PCV2 from group 2 to group 1 and the disappearance of the subgroups 1C and 2E in Korean pigs between 1999-2006 [6]. However, the precise current status of PCV2 infections is unclear because the previous study used only 16 PCV2-positive samples of pigs with PMWS during 2005-2006 [6].…”

mentioning

confidence: 99%

See 4 more Smart Citations

Genetic Diversity of Porcine Circovirus Type 2 in Korean Pigs with Postweaning Multisystemic Wasting Syndrome during 2005-2007

Kim

Park

Hyun

et al. 2009

The Journal of Veterinary Medical Science

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ABSTRACT. The comparison of nucleotide and deduced amino acid sequence was conducted with 9 porcine circovirus type 2 (PCV2) strains isolated from PCV2-infected pigs with postweaning multisystemic wasting syndrome (PMWS) and 50 tissue samples obtained from PCV2-infected 50 pigs with PMWS during [2005][2006][2007]. At amino acid positions 88-89 of the ORF2 gene, 50 Korean PCV2 had amino acids PR/L consistent with group 1 PCV2, whereas 9 Korean PCV2 contained amino acids KI, characteristic of group 2 PCV2. Phylogenetically, 47, 3, 2 and 7 Korean PCV2 belonged to subgroups 1A/B (79.7%), 1C (5.1%), 2D (3.4%) and 2E (11.9%), respectively. Although the predominant Korean PCV2 was subgroup 1A/B, subgroups 1C and 2E were still circulating and subgroup 2D PCV2 were found to be newly emerged in Korea. KEY WORDS: Korean pig, porcine circovirus type 2, prevalence.

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contrasting

confidence: 99%

supporting

confidence: 93%

“…Since the subgroups of PCV2 circulating in Korean pigs have been reported to be 1A/B, 1C and 2E [6], the above result suggests that subgroup 2D PCV2 has newly emerged in Korea (Fig. 1).…”

mentioning

confidence: 77%

mentioning

confidence: 97%

mentioning

confidence: 99%

See 3 more Smart Citations

Genetic Diversity of Porcine Circovirus Type 2 in Korean Pigs with Postweaning Multisystemic Wasting Syndrome during 2005-2007

Kim

Park

Hyun

et al. 2009

The Journal of Veterinary Medical Science

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Mouse models of porcine circovirus 2 infection

Ouyang

Liu

Ouyang

et al. 2018

Anim Models and Exp Med

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PCV 2 is considered the main pathogen of porcine circovirus diseases and porcine circovirus‐associated diseases ( PCVD / PCVAD ). However, the exact mechanism underlying PCVD / PCVAD is currently unknown. Mouse models of PCV 2 are valuable experimental tools that can shed light on the pathogenesis of infection and will enable the evaluation of antiviral agents and vaccine candidates. In this review, we discuss the current state of knowledge of mouse models used in PCV 2 research that has been performed to date, highlighting their strengths and limitations, as well as prospects for future PCV 2 studies.

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Population dynamics and ORF3 gene evolution of porcine circovirus type 2 circulating in Korea

et al. 2012

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This study was conducted to investigate the status and population dynamics of porcine circovirus type 2(PCV2) in Korea and to assess the molecular evolutionary pattern of the two biologically important, overlapping open reading frames, the ORF1 and ORF3 genes. A wide range of PCV2 genomic sequences (entire genome, ORF1, ORF2 and ORF3) collected between 2001 and 2010 were analyzed using the Bayesian Markov chain Monte Carlo and maximum-likelihood approaches. These techniques identified the PCV2d genotype and the 2Ek cluster of PCV2a in Korea for the first time. Second, the genotypic shift of PCV2b dominating over PCV2a likely occurred between 2002 and 2004 due to a population expansion of PCV2b. In the context of positive Darwinian selection, the results uncovered independent evolutionary patterns in the ORF3 gene compared to the overlapping ORF1 gene and new sites in the viral ORFs/proteins that might relate to differences in the biological properties of the PCV2 groups.

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Phylogenetic characterization of porcine circovirus type 2 in PMWS and PDNS Korean pigs between 1999 and 2006

Cited by 69 publications

References 28 publications

Genetic Diversity of Porcine Circovirus Type 2 in Korean Pigs with Postweaning Multisystemic Wasting Syndrome during 2005-2007

Genetic Diversity of Porcine Circovirus Type 2 in Korean Pigs with Postweaning Multisystemic Wasting Syndrome during 2005-2007

Mouse models of porcine circovirus 2 infection

Population dynamics and ORF3 gene evolution of porcine circovirus type 2 circulating in Korea

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