Phylogenetic distribution of catalase-peroxidases: Are there patches of order in chaos?

Passardi, Filippo; Zámocký, Marcel; Favet, Jocelyne; Jakopitsch, Christa; Penel, Claude; Obinger, Christian; Dunand, Christophe

doi:10.1016/j.gene.2007.04.016

Cited by 94 publications

(59 citation statements)

References 41 publications

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“…For example, prokaryotes preferentially acquire genes from other prokaryotes when both share the same aerobic/anaerobic environments ( Jain et al, 2003). As evidence for this hypothesis, Passardi et al (2007) indeed found that HGT for ''antioxidant genes'' encoding catalaseperoxidases occurred between prokaryotes showing similar O 2 tolerance. It should be noted that even if HGT is an important evolutionary phenomenon, it does not affect all genes to the same extent ).…”

Section: The Alternative Hypothesis and Horizontal Gene Transfer (Hgt)mentioning

confidence: 85%

Oxygen and Hydrogen Peroxide in the Early Evolution of Life on Earth:In silicoComparative Analysis of Biochemical Pathways

Ślesak

Kruk

2012

Astrobiology

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In the Universe, oxygen is the third most widespread element, while on Earth it is the most abundant one. Moreover, oxygen is a major constituent of all biopolymers fundamental to living organisms. Besides O 2 , reactive oxygen species (ROS), among them hydrogen peroxide (H 2 O 2 ), are also important reactants in the present aerobic metabolism. According to a widely accepted hypothesis, aerobic metabolism and many other reactions/pathways involving O 2 appeared after the evolution of oxygenic photosynthesis. In this study, the hypothesis was formulated that the Last Universal Common Ancestor (LUCA) was at least able to tolerate O 2 and detoxify ROS in a primordial environment. A comparative analysis was carried out of a number of the O 2 -and H 2 O 2 -involving metabolic reactions that occur in strict anaerobes, facultative anaerobes, and aerobes. The results indicate that the most likely LUCA possessed O 2 -and H 2 O 2 -involving pathways, mainly reactions to remove ROS, and had, at least in part, the components of aerobic respiration. Based on this, the presence of a low, but significant, quantity of H 2 O 2 and O 2 should be taken into account in theoretical models of the early Archean atmosphere and oceans and the evolution of life. It is suggested that the early metabolism involving O 2 /H 2 O 2 was a key adaptation of LUCA to already existing weakly oxic zones in Earth's primordial environment.

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Section: The Alternative Hypothesis and Horizontal Gene Transfer (Hgt)mentioning

confidence: 85%

Oxygen and Hydrogen Peroxide in the Early Evolution of Life on Earth:In silicoComparative Analysis of Biochemical Pathways

Ślesak

Kruk

2012

Astrobiology

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“…The monofunctional catalases and the catalase-peroxidases contain heme as a prosthetic group. In contrast to the ubiquitous distribution of monofunctional catalases from prokaryotes to eukaryotes, most catalase-peroxidases have been found in bacteria; only a minority have been found in fungi and other eukaryotic organisms (16,43,48).…”

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confidence: 94%

Regulation of Catalase-Peroxidase KatG Is OxyR Dependent and Fur Independent in Caulobacter crescentus

et al. 2011

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Most organisms that grow in the presence of oxygen possess catalases and/or peroxidases, which are necessary for scavenging the H 2 O 2 produced by aerobic metabolism. In this work we investigate the pathways that regulate the Caulobacter crescentus katG gene, encoding the only enzyme with catalase-peroxidase function in this bacterium. The transcriptional start site of the katG gene was determined, showing a short 5 untranslated region. The katG regulatory region was mapped by serial deletions, and the results indicate that there is a single promoter, which is responsible for induction at stationary phase. An oxyR mutant strain was constructed; it showed decreased katG expression, and no KatG protein or catalase-peroxidase activity was detected in stationary-phase cell extracts, implying that OxyR is the main positive regulator of the C. crescentus katG gene. Purified OxyR protein bound to the katG regulatory region between nucleotides ؊42 and ؊91 from the transcription start site, as determined by a DNase I footprinting assay, and a canonical OxyR binding site was found in this region. Moreover, OxyR binding was shown to be redox dependent, given that only oxidized proteins bound adjacent to the ؊35 sequence of the promoter and the katG P1 promoter was activated by OxyR in an H 2 O 2 -dependent manner. On the other hand, this work showed that the iron-responsive regulator Fur does not regulate C. crescentus katG, since a fur mutant strain presented wild-type levels of katG transcription and catalase-peroxidase production and activity, and the purified Fur protein was not able to bind to the katG regulatory region.

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“…The superfamily most probably evolved from an ancestor of KatG, and phylogenetic reconstruction (Fig. 1a) suggests several lateral gene transfers (across the whole gene family) in addition to frequent duplication events (6,12). Following the acquisition of katG genes by ancient ascomycete fungi via horizontal gene transfer from Bacteroidetes (1, 6), the evolution of eukaryotic KatGs proceeded toward the dominant Clade 1, whereas evolution of the mixed archaeal and protistan Clade 2 occurred in a different way (Fig.…”

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confidence: 99%

“…Catalase-peroxidases are widespread in archaea and bacteria with about 40% of the bacteria possessing katG genes, often chaotically distributed among species (12). The catalaseperoxidase family, currently with 479 annotated sequences (PeroxiBase), is phylogenetically located at the origin of the peroxidase-catalase superfamily (6), formerly known as the superfamily of bacterial, fungal, and plant peroxidases, now containing over 6,700 annotated sequences.…”

mentioning

confidence: 99%

High Conformational Stability of Secreted Eukaryotic Catalase-peroxidases

Zámocký

García-Fernández

Gasselhuber

et al. 2012

Journal of Biological Chemistry

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Background: Eukaryotic secreted KatGs are bifunctional enzymes extensively found in phytopathogenic fungi. Results: Structural peculiarities, mainly in the N-terminal domain, dominate stability and other properties of eukaryotic secreted KatGs. Conclusion:The distinctive requirements of secreted KatGs depend on very specific and fully conserved structural features. Significance: This might be exploited to control plant fungal diseases that are jeopardizing food security worldwide.

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Phylogenetic distribution of catalase-peroxidases: Are there patches of order in chaos?

Cited by 94 publications

References 41 publications

Oxygen and Hydrogen Peroxide in the Early Evolution of Life on Earth:In silicoComparative Analysis of Biochemical Pathways

Oxygen and Hydrogen Peroxide in the Early Evolution of Life on Earth:In silicoComparative Analysis of Biochemical Pathways

Regulation of Catalase-Peroxidase KatG Is OxyR Dependent and Fur Independent in Caulobacter crescentus

High Conformational Stability of Secreted Eukaryotic Catalase-peroxidases

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