2018
DOI: 10.4103/jomfp.jomfp_265_18
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Physaliphorous cells

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Cited by 8 publications
(5 citation statements)
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“…4 Pathognomonic physaliphorous (vacuolated appearance) cells within myxoid stroma are typically observed in the conventional subtype. 5 Our case belongs to the chondroid subtype, which is characterized by the presence of a chondroid differentiation area within the conventional chordoma tissue. 6 The findings of previous studies suggest no notable difference in survival rate between the conventional and chondroid subtypes.…”
Section: Discussionmentioning
confidence: 93%
“…4 Pathognomonic physaliphorous (vacuolated appearance) cells within myxoid stroma are typically observed in the conventional subtype. 5 Our case belongs to the chondroid subtype, which is characterized by the presence of a chondroid differentiation area within the conventional chordoma tissue. 6 The findings of previous studies suggest no notable difference in survival rate between the conventional and chondroid subtypes.…”
Section: Discussionmentioning
confidence: 93%
“…Upon further workup, pathology showed physaliphorous cells, which are pathognomonic of chordoma. 12 Interestingly a Korean study of 52 patients with chordomas found that there were histopathological differences depending on the site of chordoma, specifically clival/intradural chordomas tend to present more with diffuse growth pattern and chondroid matrix whereas spinal/sacral chordomas demonstrate lobulating pattern. 13 Clear cell carcinoma of the lung is an exceedingly rare diagnosis.…”
Section: Discussionmentioning
confidence: 99%
“…6 Physaliphorous cells are cells with vacuolated or bubbly appearance that correspond with the notochord consisting of chordocytes with prominent vacuoles. 12 An additional histologic feature that favored chordoma was the presence of abundant fibrillary myxoid stroma. Stroma within clear cell carcinoma would be unusual, but clear cell carcinoma has been reported to rarely contain benign smooth muscle stroma which is histologically distinct from the stroma seen in Figure 4.…”
Section: Discussionmentioning
confidence: 99%
“…For reference to the histomorphology of human disc tissue, please consult the studies cited here (Boos et al, 2002;Rutges et al, 2013). Notochordal NP cells are large and vacuolated, often forming groups and clusters and described as a physaliforous cell type (Pandiar and Thammaiah, 2018). They are relatively quiescent with regards to proteoglycan metabolism, but have a marked influence on the metabolism of proteoglycans within the NP (Aguiar et al, 1999).…”
Section: Intervertebral Disc Structure and Comparative Anatomymentioning
confidence: 99%