Physcion and physcion 8-O-β-glucopyranoside: A review of their pharmacology, toxicities and pharmacokinetics

XunLi,; Liu, Yingjiao; Chu, Shifeng; Yang, Songwei; Peng, Ye; Ren, Siyu; Wen, Birui; Chen, Nai‐Hong

doi:10.1016/j.cbi.2019.06.035

Cited by 55 publications

(42 citation statements)

References 113 publications

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“…Modern pharmacological studies have showed that pharmacological and toxicological effects of Folium sennae are inseparable. It is generally accepted that a variety of anthranoids is the major contributor of diarrhea caused by Folium sennae such as sennosides, aloe-emodin, rhein, and chrysophanol [6]. Anthraquinones possessed a wide of pharmacological including laxative, anti-tumor, anti-bacterial, anti-inflammatory and other activities, but also led to hepatotoxicity, renal toxicity and genetic damage in high doses [6,7].…”

Section: Introductionmentioning

confidence: 99%

“…It is generally accepted that a variety of anthranoids is the major contributor of diarrhea caused by Folium sennae such as sennosides, aloe-emodin, rhein, and chrysophanol [6]. Anthraquinones possessed a wide of pharmacological including laxative, anti-tumor, anti-bacterial, anti-inflammatory and other activities, but also led to hepatotoxicity, renal toxicity and genetic damage in high doses [6,7]. The EMA Revised Draft Assessment Report and Herb on Senna Folium and Senna Fructus recommended that the dosage and duration of clinical application of Folium sennae need to be limited for its adverse effects of long-term abuse and potential carcinogenicity.…”

Section: Introductionmentioning

confidence: 99%

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Role of Tryptophan-Metabolizing Microbiota On Diarrhea Mice Caused by Folium sennae Extracts

Zhang

Shao

et al. 2020

Preprint

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Abstract (1) Background: Although reports have provided evidence that diarrhea caused by Folium sennae can result in intestinal flora diversity disorder, the intestinal bacterial characteristic and specific mechanism are still unknown. The objective of our study was to investigate the mechanism of diarrhea caused by Folium sennae, which was associated with intestinal bacterial characteristic reshaping and metabolic abnormality. (2) Methods: The intestinal contents of 2 groups of mice, intervened with Folium sennae extracts and distilled water respectively, were collected and its DNA was extracted for high-throughput sequencing analysis. The active compounds of Folium sennae were filtrated, and their diarrhea-related targets and metabolic pathways were predicted. Virtual Metabolic Human (VMH) was utilized to simulated metabolic function of bacteria associated with Folium sennae -induced diarrhea to verified the metabolic pathways of the drug. (3) Results: For the intervention of Folium sennae extracts, Chao1 index and Shannon index were statistical decreased. The Beta diversity clusters of mice interfered by Folium sennae extracts were distinctly separate from control group. Combining PPI network analysis, cytochrome P450 (CYP) enzymes metabolism was the main signaling pathway of diarrhea caused by Folium sennae. Moreover, the abundance of 10 bacterial flora communities had statistical significance with Folium sennae intervention: the abundance of Paraprevotella, streptococcus, Epulopiscium, Sutterella and Mycoplasma were increased significantly; and the abundance of Adlercreutzia, Lactobacillus, Dehalobacterium, Dorea and Oscillospira were reduced significantly. 7 of the 10 intestinal flora communities were related to the synthesis of tryptophan derivatives, which affected the transformation of aminotryptophan into L-tryptophan, leading to abnormal tryptophan metabolism in the host. (4) Conclusions: Folium sennae targeted cytochrome P450 (CYP) 3A4 to alterd intestinal bacterial characteristic and interven the tryptophan metabolism of intestinal microflora, such as Streptococcus, Sutterella and Dorea, which could be the intestinal microecological mechanism of diarrhea caused by Folium sennae extracts.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Role of Tryptophan-Metabolizing Microbiota On Diarrhea Mice Caused by Folium sennae Extracts

Zhang

Shao

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Modern pharmacological studies have shown that pharmacological and toxicological effects of Folium sennae are inseparable. It is generally accepted that a variety of anthranoids are the major contributor of diarrhea caused by Folium sennae such as sennosides, aloe-emodin, rhein, and chrysophanol [6]. Anthraquinones possessed a wide of pharmacological including laxative, anti-tumor, anti-bacterial, anti-inflammatory and other activities, but also led to hepatotoxicity, renal toxicity and genetic damage in high doses [6,7].…”

Section: Introductionmentioning

confidence: 99%

“…It is generally accepted that a variety of anthranoids are the major contributor of diarrhea caused by Folium sennae such as sennosides, aloe-emodin, rhein, and chrysophanol [6]. Anthraquinones possessed a wide of pharmacological including laxative, anti-tumor, anti-bacterial, anti-inflammatory and other activities, but also led to hepatotoxicity, renal toxicity and genetic damage in high doses [6,7]. The European Medicines Agency Revised Draft Assessment Report and Herb on Senna Folium and Senna Fructus recommended that the dosage and duration of clinical application of Folium sennae need to be limited for its adverse effects of longterm abuse and potential carcinogenicity.…”

Section: Introductionmentioning

confidence: 99%

“…As far as the future in-depth research of pharmacological activity, clinical efficacy and safety, there represents a challenge to isolate the new potential chemical compounds with suggestive classes [8]. Besides, animal experiments have suggested that Folium sennae constituents caused liver injury in rats through metabolism disorder [6]; and serum adrenocorticotropic hormone and 24 h urine 17hydroxycorticosteroid were significantly reduced in rats with a high concentration and long-term gastric administration of a senna leaf decoction [9]. Even though experimental evidence supported diarrhea caused by Folium sennae could affect multiple systems of an organism, and what is more the growth of microorganisms [6], the pharmacological activities is largely unknown so far.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Role of Tryptophan-Metabolizing Microbiota On Diarrhea Mice Caused by Folium sennae Extracts

Zhang

Shao

et al. 2020

Preprint

View full text Add to dashboard Cite

Abstract Background: Although reports have provided evidence that diarrhea caused by Folium sennae can result in intestinal microbiota diversity disorder, the intestinal bacterial characteristic and specific mechanism are still unknown. The objective of our study was to investigate the mechanism of diarrhea caused by Folium sennae, which was associated with intestinal bacterial characteristic reshaping and metabolic abnormality. Results: For the intervention of Folium sennae extracts, Chao1 index and Shannon index were statistical decreased. The Beta diversity clusters of mice interfered by Folium sennae extracts were distinctly separated from control group. Combining PPI network analysis, cytochrome P450 enzymes metabolism was the main signaling pathway of diarrhea caused by Folium sennae. Moreover, 10 bacterial flora communities had statistical significant difference with Folium sennae intervention: the abundance of Paraprevotella, Streptococcus, Epulopiscium, Sutterella and Mycoplasma increased significantly; and the abundance of Adlercreutzia, Lactobacillus, Dehalobacterium, Dorea and Oscillospira reduced significantly. 7 of the 10 intestinal microbiota communities were related to the synthesis of tryptophan derivatives, which affected the transformation of aminotryptophan into L-tryptophan, leading to abnormal tryptophan metabolism in the host. Conclusions: Folium sennae targeted cytochrome P450 3A4 to alter intestinal bacterial characteristic and intervene the tryptophan metabolism of intestinal microbiota, such as Streptococcus, Sutterella and Dorea, which could be the intestinal microecological mechanism of diarrhea caused by Folium sennae extracts.

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Two New Compounds Isolated from the Itea omeiensis and Their Anti‐oxidant Activities

Feng,

Jian,

Cheng

et al. 2024

Chemistry & Biodiversity

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Two new compounds (1‐2) together with ten known compounds (3‐12) were isolated for the first time from the 95% EtOH extract of aerial parts of Itea omeinesis. Their structures were elucidated based on extensive spectroscopic analyses and comparison with published data. The structure of 1 was further confirmed through single‐crystal X‐ray diffraction analysis, and circular dichroism (CD) spectrum in combination with acid hydrolysis was employed for the absolute configuration determination of 2. Compound 1 was the first 2‐arylbenzo[b]furan with an extra six‐membered lactone ring from Itea plants. Anti‐oxidant assays indicated that compound 1 possessed significant radical scavenging effects on 1,1‐Diphenyl‐2‐picrylhydrazyl (DPPH) and 2,2'‐Azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid) (ABTS·+) with IC50 values of 0.14 and 0.06 mg/mL, respectively, which were comparable to the positive control of ascorbic acid. However, no obvious anti‐hepatocellular carcinoma activity was observed for compounds 1 and 2.

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Physcion and physcion 8-O-β-glucopyranoside: A review of their pharmacology, toxicities and pharmacokinetics

Cited by 55 publications

References 113 publications

Role of Tryptophan-Metabolizing Microbiota On Diarrhea Mice Caused by Folium sennae Extracts

Role of Tryptophan-Metabolizing Microbiota On Diarrhea Mice Caused by Folium sennae Extracts

Role of Tryptophan-Metabolizing Microbiota On Diarrhea Mice Caused by Folium sennae Extracts

Two New Compounds Isolated from the Itea omeiensis and Their Anti‐oxidant Activities

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