Physical activity ameliorates the function of organs via adipose tissue in metabolic diseases

Taghian, Farzaneh; Hajibabaie, Fatemeh

doi:10.1016/j.acthis.2022.151844

Cited by 32 publications

(35 citation statements)

References 130 publications

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“…Furthermore, growing evidence reported that AGE-receptor expression levels in neurodegenerative disorders were upregulated compared to normal subjects’ samples [ 53 ]. These outcomes obtained from previous studies verified that RAGE is a facilitator for neuropathologic alteration [ 54 , 55 ]. In the other study, Cristina Luceri et al mentioned that the expression profile of advanced glycation end-products (AGEs) could increase the inflammation condition of intestinal tissue [ 56 ].…”

Section: Discussionsupporting

confidence: 77%

“…Accordingly, physical activity and exercise training have been identified as helpful treatment techniques and mind–body practice in complementary and alternative health approaches [ 62 ]. Regular exercise training may significantly influence physical performance, cognitive improvement, metabolism, microbiota balance, neurohumoral adaptation, and hormone function on a long-term basis [ 55 , 63 ].…”

Section: Discussionmentioning

confidence: 99%

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Cross Brain–Gut Analysis Highlighted Hub Genes and LncRNA Networks Differentially Modified During Leucine Consumption and Endurance Exercise in Mice with Depression-Like Behaviors

Taghian

Hajibabaie

2022

Mol Neurobiol

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Cross Brain–Gut Analysis Highlighted Hub Genes and LncRNA Networks Differentially Modified During Leucine Consumption and Endurance Exercise in Mice with Depression-Like Behaviors

Taghian

Hajibabaie

2022

Mol Neurobiol

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“…Physical activity and mobility ameliorate modulating neurotransmitters in the central and peripheral nervous systems [ 34 ]. Furthermore, based on the evidence, exercise and physical activity enhanced the muscle strength and motor capacity of MS patients [ 35 – 37 ].…”

Section: Discussionmentioning

confidence: 99%

The functional mechanisms of synchronizing royal jelly consumption and physical activity on rat with multiple sclerosis-like behaviors hallmarks based on bioinformatics analysis, and experimental survey

et al. 2022

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Background Natural nutrition and physical training have been defined as non-pharmacochemical complementary and alternative medicines to prevent and treat various pathogenesis. Royal jelly possesses various pharmacological properties and is an effective therapeutic supplement for halting neurodegeneration. Multiple sclerosis is a prevalent neurodegenerative disorder that manifests as a progressive neurological condition. Inflammation, hypoxia, and oxidative stress have been identified as significant hallmarks of multiple sclerosis pathology. Results In the present study, based on artificial intelligence and bioinformatics algorithms, we marked hub genes, molecular signaling pathways, and molecular regulators such as non-coding RNAs involved in multiple sclerosis. Also, microRNAs as regulators can affect gene expression in many processes. Numerous pathomechanisms, including immunodeficiency, hypoxia, oxidative stress, neuroinflammation, and mitochondrial dysfunction, can play a significant role in the MSc pathogenesis that results in demyelination. Furthermore, we computed the binding affinity of bioactive compounds presented in Royal Jelly on macromolecules surfaces. Also, we predicted the alignment score of bioactive compounds over the pharmacophore model of candidate protein as a novel therapeutic approach. Based on the q-RT-PCR analysis, the expression of the Dnajb1/Dnajb1/Foxp1/Tnfsf14 and Hspa4 networks as well as miR-34a-5p and miR155-3p were regulated by the interaction of exercise training and 100 mg/kg Royal Jelly (ET-100RJ). Interestingly, characteristics, motor function, a proinflammatory cytokine, and demyelination were ameliorated by ET-100RJ. Discussion Here, we indicated that interaction between exercise training and 100 mg/kg Royal jelly had a more effect on regulating the microRNA profiles and hub genes in rats with Multiple sclerosis.

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“…The process of aging is biologically associated with marked alterations in the body composition, which can adversely influence the functionality of elderly individuals, such as a gradual reduction in muscle mass, its quality, and strength, as well as an increment in fat mass (Abedpoor et al, 2022; Distefano & Goodpaster, 2018; Kalyani et al, 2014). In addition, skeletal muscle atrophy is characterized by the loss of muscle mass due to numerous noncommunicable and communicable diseases such as type 2 diabetes (Atherton et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

The effect of resistance and endurance training with ursolic acid on atrophy‐related biomarkers in muscle tissue of diabetic male rats induced by streptozotocin and ahigh‐fatdiet

Zolfaghari

Faramarzi

Hedayati

et al. 2022

Journal of Food Biochemistry

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In this study, the effect of resistance and endurance training with/without ursolic acid supplementation was evaluated to identify atrophy‐related biomarkers in elderly rats induced by diabetes and a high‐fat diet (HFD) based on in silico analysis algorithms and pharmaceutical methods. The visualizer software found differential gene expression levels in skeletal muscle atrophy via computed hub gene network parameters. Also, the impact of ursolic acid, as a potent inducer of the Trp53 protein in ameliorating decreased muscle mass, was analyzed in diabetic rats. Fifty‐six‐old male Wistar rats were randomly assigned into seven groups, including healthy control (Control), diabetic control (DM), Ursolic acid supplementation (UA), resistance training (RT), endurance training (ET), resistance training+ Ursolic acid supplementation (RT + U), and endurance training in combination with Ursolic acid supplementation (ET + U). Exercise intervention included 8 weeks of resistance or endurance training programs. Biomedical informatic outputs determined the P53 signaling pathway as a remarkable causative factor in the pathomechanism of atrophy. In addition, the results demonstrated that exercise and supplementation of UA impeded the interactions among p53/ATF4/p21. Moreover, ET and ursolic acid had a synergetic effect on the signaling pathway of p53/ATF4/p21 and probably could inhibit the aging process and modulate the p53/ATF4/p21 molecular pathway. The interaction between UA and endurance exercise significantly modified the activity of the p53/ATF4/p21 signaling pathway. Based on in silico studies, the p53/ATF4/p21 pathway plays an essential role in aging, and the inhibition of this pathway would be beneficial in decelerating the aging process. Practical applications Ursolic acid (UA) is a natural pentacyclic triterpenoid carboxylic acid found in apples (a major compound of apple wax) and other fruits; it is known to improve skeletal muscle function and reduce the muscular atrophy pathways. We indicated that p53/ATF4/p21 signaling is an essential factor in aging, and the suppression of this pathway could be beneficial in the deceleration of the aging process. Therefore, this work would shed light on understanding the effect of exercise and nutrition interventions on preventing atrophy markers of skeletal muscle in diabetic rats. Further studies are needed to seek the precise mechanism of the synergism between UA and exercise in ameliorating atrophy markers.

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Physical activity ameliorates the function of organs via adipose tissue in metabolic diseases

Cited by 32 publications

References 130 publications

Cross Brain–Gut Analysis Highlighted Hub Genes and LncRNA Networks Differentially Modified During Leucine Consumption and Endurance Exercise in Mice with Depression-Like Behaviors

Cross Brain–Gut Analysis Highlighted Hub Genes and LncRNA Networks Differentially Modified During Leucine Consumption and Endurance Exercise in Mice with Depression-Like Behaviors

The functional mechanisms of synchronizing royal jelly consumption and physical activity on rat with multiple sclerosis-like behaviors hallmarks based on bioinformatics analysis, and experimental survey

The effect of resistance and endurance training with ursolic acid on atrophy‐related biomarkers in muscle tissue of diabetic male rats induced by streptozotocin and ahigh‐fatdiet

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