Physical activity and exercise: Strategies to manage frailty

Angulo, Javier; Assar, Mariam El; Álvarez‐Bustos, Alejandro; Rodríguez‐Mañas, Leocadio

doi:10.1016/j.redox.2020.101513

Cited by 390 publications

(290 citation statements)

References 293 publications

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“…Also, symptoms such as fear and sleeping disturbances should be properly identified and addressed (Berg-Weger and Morley, 2020 ). Physical frailty can be resolved through educational videos and recorded physical activity sessions (Angulo et al, 2020 ). Actually, online technologies are the most valuable support systems, but have to be appropriately planned for older minds (Meinert et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Consequences for the Elderly After COVID-19 Isolation: FEaR (Frail Elderly amid Restrictions)

et al. 2020

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Section: Discussionmentioning

confidence: 99%

Consequences for the Elderly After COVID-19 Isolation: FEaR (Frail Elderly amid Restrictions)

et al. 2020

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“…Specific diagnostic criteria for sarcopenia continues to evolve (Cruz-Jentoft et al, 2010;Studenski et al, 2014), but it manifests with increased insulin resistance, loss of bone density, and an increase in falls (Dutta and Hadley, 1995;Rantanen et al, 1999). As such, these patients are at an increased risk of all-cause mortality, incident and mobility disabilities, and loss of independence (Angulo et al, 2020). From a public health perspective, the economic burden of caring for sarcopenic patients is tremendous and accounts for nearly $28.5 billion per year in expenditures, after adjusting for inflation (Janssen et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Optimizing Skeletal Muscle Anabolic Response to Resistance Training in Aging

2020

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Loss of muscle mass and strength with aging, also termed sarcopenia, results in a loss of mobility and independence. Exercise, particularly resistance training, has proven to be beneficial in counteracting the aging-associated loss of skeletal muscle mass and function. However, the anabolic response to exercise in old age is not as robust, with blunted improvements in muscle size, strength, and function in comparison to younger individuals. This review provides an overview of several physiological changes which may contribute to age-related loss of muscle mass and decreased anabolism in response to resistance training in the elderly. Additionally, the following supplemental therapies with potential to synergize with resistance training to increase muscle mass are discussed: nutrition, creatine, anti-inflammatory drugs, testosterone, and growth hormone (GH). Although these interventions hold some promise, further research is necessary to optimize the response to exercise in elderly patients.

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“…Even MCT seems to be effective improving physical fitness [ 5 ], this MCT may not be the best protocol for the improvement of bone mass, although it seems useful to slightly minimize the detrimental effect of ageing in bone in pre-frail and frail elders. The lack of clearer results may be partially explained due to the TRAIN group showing greater baseline values, which could lead to a higher probability of losses and also to the small statistical power related with our small cohort.…”

Section: Discussionmentioning

confidence: 99%

“…Due to its reversible nature, especially at early stages during pre-frailty [ 2 ], researchers are still looking for the best treatment to mitigate frailty and reduce its association with morbility and mortality [ 3 , 4 ]. In this line, evidence points out multicomponent training (MCT) programs as one of the most effective interventions in this population, especially to improve physical function [ 5 ]. However, less is known about its effects on other bodily impairments associated with ageing, such as the impairment of bone mass and structure.…”

Section: Introductionmentioning

confidence: 99%

Role of Dietary Intake and Serum 25(OH)D on the Effects of a Multicomponent Exercise Program on Bone Mass and Structure of Frail and Pre-Frail Older Adults

et al. 2020

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The multicomponent training (MCT) effect on bone health in frail and pre-frail elders, which is influenced by dietary intake, is still unknown. The objective of this non-randomized intervention trial was to assess the effects of a 6-month MCT on bone structure in frail and pre-frail elders, and to analyse the influence of dietary intake and serum vitamin D (25(OH)D) in these changes. Thirty MCT (TRAIN) and sixteen controls (CON), frail and pre-frail completed the information required for this study. Peripheral quantitative computed tomography measurements were taken at 4% and 38% of the tibia length and dietary intake was registered. The 25(OH)D values were obtained from blood samples. Analyses of covariance (ANCOVA) for repeated measures showed significant decreases for CON in total bone mineral content at 38% of tibia length. One factor ANOVAs showed smaller decreases in bone mineral density and cortical thickness percentage of change in TRAIN compared to CON. Linear regression analyses were performed to study the influence of nutrients and 25(OH)D on bone changes. Alcohol showed a negative influence on fracture index changes, while polyunsaturated fatty acid and vitamin A showed a positive association with some bone variables. The 25(OH)D only affected positively the cortical bone mineral density. In conclusion, our MCT seems to slow down some of the bone detriments associated with ageing in frail and pre-frail older adults, with alcohol showing a negative effect on the bone and apparent limited effect of nutrients and serum 25(OH)D on training related changes.

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Physical activity and exercise: Strategies to manage frailty

Cited by 390 publications

References 293 publications

Consequences for the Elderly After COVID-19 Isolation: FEaR (Frail Elderly amid Restrictions)

Consequences for the Elderly After COVID-19 Isolation: FEaR (Frail Elderly amid Restrictions)

Optimizing Skeletal Muscle Anabolic Response to Resistance Training in Aging

Role of Dietary Intake and Serum 25(OH)D on the Effects of a Multicomponent Exercise Program on Bone Mass and Structure of Frail and Pre-Frail Older Adults

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