Physical activity behaviors in cancer survivors treated with neurotoxic chemotherapy

Mizrahi, David; Goldstein, David; Trinh, Terry; Li, Tiffany; Timmins, Hannah C.; Harrison, Michelle; Marx, Gavin; Hovey, Elizabeth; Lewis, Craig; Friedlander, Michael; Park, Susanna B.

doi:10.1111/ajco.13834

Cited by 3 publications

(2 citation statements)

References 51 publications

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“…Like hand-foot syndrome, this effect is associated with falls and balance problems [49]. Other literature states that neuropathy is associated with anxiety, depression, insomnia, and falls (p < 0.05) [50,51]. Finally, a point to note is that after treatment, problems such as neuropathy can be persistent and favor barriers related to sensorimotor and mobility deficits.…”

Section: Literature Gap From the Foot Health Perspective: A Challenge...mentioning

confidence: 99%

“…Finally, a point to note is that after treatment, problems such as neuropathy can be persistent and favor barriers related to sensorimotor and mobility deficits. This is associated with the possibility of not performing physical activity, decreased ambulation, and an increased body mass index, which may be correlated with other health problems [28,51].…”

Section: Literature Gap From the Foot Health Perspective: A Challenge...mentioning

confidence: 99%

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Foot Health in People with Cancer Undergoing Chemotherapy: A Scoping Review

Veiga-Seijo

González-Martín

2023

Healthcare

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Background: Chemotherapy has relevant implications for cancer patients’ physical, social, and psychological health. Foot health has gained relevance in recent years due to its importance to independence and wellbeing, especially in chronic conditions. This study aims to explore the scope of the literature regarding foot health problems in people with cancer undergoing chemotherapy. Methods: scoping review following the PRISMA-ScR, Arksey and O’Malley, and the Joanna Briggs Institute guidelines. Different databases were used (Cochrane Plus, Scopus, Web of Science, and Pubmed). A total of 4911 articles were identified. Finally, 11 papers were included. Results: Foot problems are relevant and deteriorate wellbeing. The prevalence of some podiatric pathologies is controversial. The main literature deals with hand–foot syndrome and peripheral neuropathy. Focused instruments on foot health were not thoroughly used. Conclusion: There is insufficient evidence on foot health problems and their influence on the quality of life of people with cancer undergoing chemotherapy. Even though a significant percentage of this population has a foot problem, its care and importance are neglected. More studies are needed to contribute to the care of people with cancer through foot health.

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Section: Literature Gap From the Foot Health Perspective: A Challenge...mentioning

confidence: 99%

Section: Literature Gap From the Foot Health Perspective: A Challenge...mentioning

confidence: 99%

Foot Health in People with Cancer Undergoing Chemotherapy: A Scoping Review

Veiga-Seijo

González-Martín

2023

Healthcare

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Physical function as a predictor of chemotherapy-induced peripheral neuropathy in patients with pancreatic cancer

Lin,

Chen,

Lin

2024

BMC Gastroenterol

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Background A growing body of research indicates that poor functional status before chemotherapy may be correlated with the severity of chemotherapy-induced peripheral neuropathy (CIPN) after the neurotoxic treatment. However, little is known about the associations between pre-chemotherapy physical function and CIPN in patients with pancreatic cancer. Purpose To identify the predictors of CIPN in relation to pre-chemotherapy physical function in patients with pancreatic cancer. Methods This secondary analysis included data from patients with pancreatic cancer who participated in a longitudinal research study at National Cheng Kung University Hospital, Tainan, Taiwan. Four physical function tests (i.e., grip strength, Timed Up and Go (TUG), 2-minute step test (2MST), and Romberg test) and two questionnaires (The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 [EORTC QLQ-C30] and Chemotherapy-Induced Peripheral Neuropathy Module [CIPN20]) were assessed at baseline (i.e., before first chemotherapy session) and 2-, 3-, 4-, and 6-month follow-up. Multiple linear regression with adjustment for confounding factors was used to assess the associations between the four functional tests at baseline and the CIPN20 total score and individual subscale scores (sensory, motor, and autonomic) at 6-month follow-up. Results Data from a total of 209 pancreatic cancer patients (mean age: 64.4 years, 54.5% male) were analyzed. The findings showed that the severity of CIPN at 6-month follow-up was significantly associated with the baseline TUG completion time (β = 0.684, p = 0.003). The TUG completion time was also positively correlated with the 6-month CIPN sensory and autonomic subscales. In addition, a baseline positive Romberg test (β = 0.525, p = 0.009) was a significant predictor of the severity of motor neuropathy at 6-month follow-up. Conclusion The TUG completion time and positive Romberg test before chemotherapy may be predictive factors of the CIPN severity 6 months after the commencement of chemotherapy. Accordingly, the incorporation of TUG and Romberg tests into the clinical assessment protocol emerges as imperative for individuals diagnosed with pancreatic carcinoma undergoing chemotherapy regimens.

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Living with chemotherapy-induced peripheral neuropathy: a nested qualitative study

Mackereth,

Stringer

2023

Br J Nurs

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Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting side-effect for patients undergoing a variety of chemotherapy regimens. These effects can have a detrimental impact on patients' quality of life and ability to perform everyday tasks. Objective: This study aimed to explore the experience of living with CIPN prior to and while participating in a randomised study of acupuncture versus a control wait group. Design: The study was nested within a randomised trial (n=120) with participants randomised to acupuncture or to control (wait list for acupuncture). Method: Participants (n=23) volunteered to be interviewed either by telephone (n=20) or face to face (n=3). The audiotapes produced were transcribed verbatim and analysed using a thematic approach. Results: Four themes developed; these included daily life with CIPN, signs and symptoms, interacting with others and management of CIPN. Patients reported compromised dexterity and ability to safely carry out activities. They were often reliant on help and sought out information from others living with the condition. There were also concerns about the lack of effectiveness and the side-effects of medication prescribed. Conclusion: Participants were self-selecting volunteers across different cancer groups, but the information gathered could influence future study designs and increase understanding of the impact of CIPN on patients' lives.

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Physical activity behaviors in cancer survivors treated with neurotoxic chemotherapy

Cited by 3 publications

References 51 publications

Foot Health in People with Cancer Undergoing Chemotherapy: A Scoping Review

Foot Health in People with Cancer Undergoing Chemotherapy: A Scoping Review

Physical function as a predictor of chemotherapy-induced peripheral neuropathy in patients with pancreatic cancer

Living with chemotherapy-induced peripheral neuropathy: a nested qualitative study

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