Physical Activity Improves the Metabolic Risk Profiles in Men and Women

Thune, Inger; Njølstad, Inger; Løchen, Maja‐Lisa; Førde, Olav Helge

doi:10.1001/archinte.158.15.1633

Cited by 120 publications

(98 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moreover, the accuracy of the levels of recreational activity reported on the questionnaire has been validated and the level of recreational activity correlates positively with physical fitness. [55][56][57] The findings in our study that women who were sedentary in their leisure time had a higher BMI and a significant dyslipidemia relative to those who were active (p Ͻ 0.05 for higher BMI, serum LDL/HDL ratio and serum triglycerides in inactive vs. active, age adjusted; results not shown) strengthen the validity of our assessment.…”

Section: Discussionsupporting

confidence: 59%

Metabolic abnormalities (hypertension, hyperglycemia and overweight), lifestyle (high energy intake and physical inactivity) and endometrial cancer risk in a Norwegian cohort

Furberg

Thune

2003

Intl Journal of Cancer

Self Cite

210

184

View full text Add to dashboard Cite

Since high energy intake, inactivity, hypertension and diabetes are linked to obesity and an unfavorable hormonal profile, we wanted to test whether energy intake, physical activity, blood pressure and serum glucose are related to the risk of endometrial cancer independent of the body mass index (BMI The wide differences in incidence of endometrial cancer (type I-carcinoma) across countries and between urban and rural populations, as well as the changing disease incidence in migrants, indicate that environmental factors have a huge influence on the occurrence of the disease. 1 The etiology of endometrial cancer is unknown, yet it has been shown that malignant transformation, cancer cell proliferation, tumor invasion and tumor progression are enhanced by deficiency in progesterone and its action relative to estrogen in the glandular cells of the endometrium. 2,3 A shift in energy balance (e.g., excessive energy intake relative to energy expenditure) might contribute to an unfavorable sex hormone profile in women. 2,4 Epidemiological studies on the association between energy intake and the risk of endometrial cancer are inconclusive. 5-10 A chronically excessive intake of energy relative to requirements may lead to increased body weight. Although adult obesity has consistently been associated with an increased risk of endometrial cancer, the effect may be age and menopausal status dependent. 11 The energy expended during physical activity may represent between 15 and 50% of total energy expenditure, depending on the amount of physical activity performed and the body mass. 12 Epidemiological studies find that inactivity may be associated with an increased endometrial cancer risk. [13][14][15][16][17][18] However, some studies indicate that the effect may be dependent on type of activity (i.e., during work and recreation). 19,20 We have previously reported on the effect of activity, energy intake and accurately measured body mass on the incidence of breast cancer 21 and similar studies on endometrial cancer are needed. 11 Body mass and endogenous levels of estrogens have been associated with risk independently of each other, 22,23 suggesting that the unopposed estrogen/relative progesterone deficiency hypothesis is insufficient to explain endometrial cancer. It has been hypothesized that insulin, a growth factor known for its mitogenic activity, 24,25 plays a major role in endometrial carcinogenesis. Hypertension and diabetes are markers of insulin resistance/hyperinsulinemia. 26,27 Observations linking blood pressure, glucose metabolism and markers of insulin resistance to endometrial cancer come mostly from retrospective studies, which have provided less conclusive results because of self-reported disease history and anthropometry or an absence of adjustment for body mass. 1 We analyzed data that included repeated assessments of variables from a cohort of 24,460 Norwegian women to elucidate whether energy intake, recreational and occupational activity, blood pressure and serum glucose concentration are associated ...

show abstract

Section: Discussionsupporting

confidence: 59%

Metabolic abnormalities (hypertension, hyperglycemia and overweight), lifestyle (high energy intake and physical inactivity) and endometrial cancer risk in a Norwegian cohort

Furberg

Thune

2003

Intl Journal of Cancer

Self Cite

210

184

View full text Add to dashboard Cite

show abstract

“…Benefits to the circulatory system include influences on the lipoprotein metabolism, inflammatory markers, endothelial function and insulin resistance. [39][40][41][42][43][44][45][46] Is physical activity important among those who lose weight? Our study showed that leisure time physical activity had protective effect on all-cause mortality, which is in line with numerous other studies.…”

Section: Discussionmentioning

confidence: 99%

Combined effects of weight loss and physical activity on all-cause mortality of overweight men and women

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Recent physical activity may also act through hormonal mechanisms by continuing to impact ovarian hormone levels among premenopausal women, may directly lower estrogen levels, 34 or may alter circulating estrogen levels of postmenopausal women indirectly 9 by lowering BMI or maintaining weight among postmenopausal women. [35][36][37][38] Other mechanisms that have been proposed for the protective effect of exercise on invasive breast carcinoma risk, such as alterations in immune response 39,40 and increased insulin sensitivity, 36,41 may also account for the decrease in risk of BCIS. The insulin sensitivity hypothesis is related to the previously mentioned hormonal pathway.…”

Section: Discussionmentioning

confidence: 99%

Lifetime recreational exercise activity and risk of breast carcinoma in situ

Patel

Press

Meeske

et al. 2003

Cancer

View full text Add to dashboard Cite

The aim of this study is the creation of an empirical model that can be used to predict the viscosity of a semicrystalline polymer melt for polymer process control. We have developed an empirical viscosity equation from both analysis and experimentation that takes into consideration the effect of temperature on both the flow behavior and the consistency index in the power law. The analysis is based on previously published literature, whereas the experimental data have been obtained from both the literature and laboratory investigations. The coefficients of the empirical model for low‐density polyethylene and polypropylene have been obtained from the experimental data derived from capillary rheometer measurements in the laboratory. This empirical model is able to produce results matching the experimental data with remarkable accuracy. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 88: 3045–3057, 2003

show abstract

Physical Activity Improves the Metabolic Risk Profiles in Men and Women

Cited by 120 publications

References 61 publications

Metabolic abnormalities (hypertension, hyperglycemia and overweight), lifestyle (high energy intake and physical inactivity) and endometrial cancer risk in a Norwegian cohort

Metabolic abnormalities (hypertension, hyperglycemia and overweight), lifestyle (high energy intake and physical inactivity) and endometrial cancer risk in a Norwegian cohort

Combined effects of weight loss and physical activity on all-cause mortality of overweight men and women

Lifetime recreational exercise activity and risk of breast carcinoma in situ

Contact Info

Product

Resources

About