Physical Activity Is Associated With Glucose Tolerance Independent of Microvascular Function: The Maastricht Study

Montero, David; Houben, Alfons J.H.M.; Koster, Annemarie; Muris, Dennis M.J.; Schram, Miranda T.; Gronenschild, E. H. B. M.; Sep, Simone J. S.; Henry, Ronald M.A.; Kallen, Carla; Schaper, Nicolaas C.; Dagnelie, Pieter C.; Geel, Tineke van; Kremers, Stef; Savelberg, Hans; Stehouwer, Coen D. A.

doi:10.1210/jc.2016-1526

Cited by 19 publications

(15 citation statements)

References 56 publications

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“…The majority of individuals were involved in recreational activities comprising moderate aerobic exercise for 3 to 6 h/wk. Moderate‐to‐vigorous physical activity levels were determined from established questionnaires, as previously described (21). Inclusion criteria comprised healthy status; absence of current medical symptoms or medication limiting incremental exercise testing; and no history of cardiac, pulmonary, or neuromuscular diseases.…”

Section: Methodsmentioning

confidence: 99%

Sex dimorphism in cardiac and aerobic capacities: The influence of body composition

Díaz-Cañestro

Pentz

Sehgal

et al. 2021

Obesity

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ObjectiveThe contribution of body composition to sex differences in strong prognostic cardiorespiratory variables remains unresolved. This study aimed to elucidate whether body composition determines sex differences in cardiac and oxygen (O2) uptake responses to incremental exercise.MethodsHealthy, moderately active women and men (n = 60, age = 60.7 [12.3] years) matched by age and cardiorespiratory fitness were included. Body composition was determined via dual‐energy x‐ray absorptiometry. Transthoracic echocardiography and O2 uptake were assessed at rest and throughout incremental exercise with established methods. Major cardiac and pulmonary outcomes were normalized by body surface area (BSA), total lean body mass (LBM), or leg LBM.ResultsWomen presented with smaller anthropometrical indices (height, weight, BSA) and LBM compared with men (p < 0.001). Peak exercise cardiac dimensions and output (i.e., peak cardiac outout [Qpeak]), commonly normalized by BSA, were reduced in women relative to men (p ≤ 0.019). Cardiac sex differences were abolished after normalization by total or leg LBM (p ≥ 0.115). Strong linear relationships of total and leg LBM with Qpeak and peak oxygen uptake were detected exclusively in women (r ≥ 0.53, p ≤ 0.003), independent of body fat percentage.ConclusionsTotal and leg LBM stand out as strong independent determinants of cardiac and aerobic capacities in women, regardless of body fat percentage, relationships that are not present in age‐ and fitness‐matched men.

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Section: Methodsmentioning

confidence: 99%

Sex dimorphism in cardiac and aerobic capacities: The influence of body composition

Díaz-Cañestro

Pentz

Sehgal

et al. 2021

Obesity

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“…However, a paper published more recently, clearly showed that after only 4 days of bed rest both insulin sensitivity and skeletal muscle fiber cross-sectional area decreased, while capillary density increased, in healthy young subjects ( Montero et al, 2018 ). This suggests that muscle capillaries do not primarily influence insulin sensitivity through impaired nutrient delivery in the absence of aging or pathological conditions ( Montero et al, 2016 ). The most relevant changes responsible for insulin resistance might involve the expression and/or activity of insulin receptor β-subunit, Akt, GLUT4, AMPK and many other intracellular signals known to be involved in the insulin effect ( Lassiter et al, 2018 ).…”

Section: Insulin Resistance and Endocrine Changesmentioning

confidence: 99%

Recent Progress in Space Physiology and Aging

Strollo¹,

Gentile²,

Strollo

et al. 2018

Front. Physiol.

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Astronauts coming back from long-term space missions present with different health problems potentially affecting mission performance, involving all functional systems and organs and closely resembling those found in the elderly. This review points out the most recent advances in the literature in areas of expertise in which specific research groups were particularly creative, and as they relate to aging and to possible benefits on Earth for disabled people. The update of new findings and approaches in space research refers especially to neuro-immuno-endocrine-metabolic interactions, optic nerve edema, motion sickness and muscle-tendon-bone interplay and aims at providing the curious - and even possibly naïve young researchers – with a source of inspiration and of creative ideas for translational research.

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“…Ninety healthy women and men throughout the adult lifespan (20–89 yr) were recruited via electronic/printed advertisements on community notice boards in the city of Calgary. Moderate-to-vigorous physical activity levels were determined from established questionnaires as previously described ( 17 ). Inclusion criteria comprised healthy status, absence of current medical symptoms, and no history of cardiac, pulmonary, or neuromuscular diseases.…”

Section: Methodsmentioning

confidence: 99%

Sex Differences in Orthostatic Tolerance Are Mainly Explained by Blood Volume and Oxygen Carrying Capacity

Díaz-Cañestro

Pentz

Sehgal

et al. 2022

Critical Care Explorations

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Physical Activity Is Associated With Glucose Tolerance Independent of Microvascular Function: The Maastricht Study

Cited by 19 publications

References 56 publications

Sex dimorphism in cardiac and aerobic capacities: The influence of body composition

Sex dimorphism in cardiac and aerobic capacities: The influence of body composition

Recent Progress in Space Physiology and Aging

Sex Differences in Orthostatic Tolerance Are Mainly Explained by Blood Volume and Oxygen Carrying Capacity

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