Physical activity is associated with a decreased multiple sclerosis risk: The EnvIMS study

Wesnes, Kristin; Myhr, Kjell Morten; Riise, Trond; Cortese, Marianna; Pugliatti, Maura; Boström, Inger; Landtblom, Anne‐Marie; Wolfson, Christina; Bjørnevik, Kjetil

doi:10.1177/1352458517694088

Cited by 57 publications

(37 citation statements)

References 33 publications

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“…An EnvIMS-based study concluded that vigorous physical activity may decrease the risk of development of MS, but our study found an insignificant association between vigorous physical activity and the development of MS. 32 Another study investigating lifestyle risk factors also found an insignificant association between physical activity and MS. 33 However, a large prospective study using a validated measure of physical activity found weak evidence that higher physical activity may decrease the risk of development of MS. 34 Our study found that a history of measles infection may decrease the risk of MS. Another study found a significant association between measles infection and the development of MS. 35 In a case-control study conducted in 2017 to examine environmental risk factors, a significant association was found between a history of measles or mumps and MS (OR=1.60, 95% CI 1.05-2.45, p =0.029). 36 Another study found that a history of infection during childhood (such as measles) increased the risk of MS. 37 The association between MS and measles infection has been studied for a long time, the association postulated as host response to virus infection because virus may cause demyelinating and inflammatory lesions of MS. 38 …”

Section: Discussionmentioning

confidence: 99%

Sociodemographic, environmental and lifestyle risk factors for multiple sclerosis development in the Western region of Saudi Arabia

Halawani

Zeidan

Kareem

et al. 2018

SMJ

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Objectives:To examine the association of exposure to sociodemographic, environmental, and lifestyle risk factors during adolescence with the development of multiple sclerosis (MS).Methods:We conducted a case-control study between October 2017 and January 2018 at King Fahd General Hospital (KFH) in Madinah, Saudi Arabia. Data were collected by direct physician-subject interviews. We utilized a questionnaire modified from the environmental risk factors in multiple sclerosis questionnaire (EnvIMS-Q). Chi-square tests were used to examine associations of selected risk factors with the development of MS, a p-value of <0.05 was considered significant.Results:A total of 80 cases and 160 controls were enrolled into the study. Smoking during adolescence significantly increased the risk of MS, with an adjusted odds ratio (AOR) of 4.165, and a 95% confidence interval (CI) of 1.449-11.974. Large body size, assessed using a figure rating scale, also increased the risk of MS (AOR=8.970, 95% CI=1.032-77.983), as well as a history of measles infection (AOR=3.758, 95% CI=1.455-9.706). Furthermore, exposure to sunlight during the weekend for more than 4 hours/day decreased the risk of MS (AOR=0.063, 95% CI=0.006-0.654), so did the consumption of fish for more than once per week (AOR=0.206, 95% CI=0.055-0.773).Conclusion:The risk of developing MS is significantly increased by exposure during adolescence to smoking, a history of measles infection, and large body size (obesity).

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Section: Discussionmentioning

confidence: 99%

Sociodemographic, environmental and lifestyle risk factors for multiple sclerosis development in the Western region of Saudi Arabia

Halawani

Zeidan

Kareem

et al. 2018

SMJ

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“…Recently, Wesnes and colleagues examined the role of vigorous physical activity in the context of the EnvIMS study and reported a similar association as we did after adjusting for the established MS risk factors like sun exposure and smoking. 334 Linking BMI to MS among men strengthens evidence for a role of this factor in MS etiology, as a biological difference by sex seemed little substantiated. However, this study also suggests that BMI is not a valid measure of body fat % among young men, corroborating prior concerns.…”

Section: Interpretation and Contribution Of The Findingsmentioning

confidence: 97%

Body size and physical exercise, and the risk of multiple sclerosis

et al. 2017

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“…For instance, Tehran and Isfahan with high MS prevalence have urbanizations rates of 85.43 and 92.80, respectively, while Sistan and Balouchestan with an urbanization rate of 49.05 are among the provinces with the lowest MS prevalence. Recent studies indicate that other factors associated with MS risk are also associated with urbanization, such as air pollution, low physical activity, high percentage of smokers, and vitamin D deficiency …”

Section: Discussionmentioning

confidence: 99%

Do socioeconomic factors affect the prevalence of multiple sclerosis in Iran?

et al. 2019

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Background A rising trend for incidence of multiple sclerosis (MS) has been observed during the recent years in Iran. Several factors have been investigated as the reason, but socioeconomic determinants have been neglected. The present study aimed to investigate the relationship between Human Development Index (HDI), income and education and MS prevalence in the provinces of Iran. Methods The data used in this study were obtained from three sources: (a) National Registry of MS for MS prevalence data from 2006 to 2013, (b) Statistical Centre of Iran for demographic, income, and percentage of educated people data, and (c) some previous studies for HDI data. Results The findings showed high prevalence of MS in the provinces of Iran. Most patients were residents of provinces with a higher socioeconomic level. Significant relationships were found between the prevalence of MS and HDI, income and educational level (P = .002, P = .006, and P = .001, respectively). Conclusion Socioeconomic determinants in Iran are different from those in many other countries. It seems that Iranian provinces with a higher socioeconomic level have higher prevalence of MS. Further studies in smaller scale are needed to better understand the relationship between socioeconomic determinants and MS prevalence in the provinces of Iran.

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Physical activity is associated with a decreased multiple sclerosis risk: The EnvIMS study

Abstract: Our findings suggest that vigorous PA can modify the risk of developing MS independent of established risk factors.

Cited by 57 publications

References 33 publications

Sociodemographic, environmental and lifestyle risk factors for multiple sclerosis development in the Western region of Saudi Arabia

Sociodemographic, environmental and lifestyle risk factors for multiple sclerosis development in the Western region of Saudi Arabia

Body size and physical exercise, and the risk of multiple sclerosis

Do socioeconomic factors affect the prevalence of multiple sclerosis in Iran?

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