Physical activity modifies the association between CYBA gene polymorphisms and small artery elasticity in a Chinese population

Zhu, Zaiou; Zhang, Haifeng; Yao, Wenming; Liang, Ning; Gong, Liang; Yin, Zhi-Jian; Chen, Fu-kuan; Cao, Kejiang; Li, Xinli

doi:10.1038/hr.2012.23

Cited by 14 publications

(8 citation statements)

References 32 publications

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“…The protocol was approved by the Ethics Committee of the First Affiliated Hospital with Nanjing Medical University. Informed consent was obtained and signed by each participant [ 10 , 11 ].…”

Section: Methodsmentioning

confidence: 99%

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Prevalence and associated factors of knee osteoarthritis in a rural Chinese adult population: an epidemiological survey

et al. 2015

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BackgroundThe exact pathogenic mechanism of knee osteoarthritis (OA) is still unknown. With the exception of clinical treatment to alleviate symptoms, or total knee replacement, there is currently no effective treatment method. Consequently, an in-depth etiological and epidemiological study of knee OA can provide clues for diagnosis, treatment and scientific research, and will ultimately have a beneficial effect on public health.MethodsA cross-sectional community study in the rural village of Gaoyou was conducted in 3428 Chinese adults (aged ≥ 40 years). Subjects completed an interviewer-administered questionnaire, evaluating knee pain and associated disability, analgesia, use of health services, past medical history, walking, income, smoking, and use of oral contraceptives, and standardized weight-bearing knee radiographs were obtained. Patient demographic characteristics and biochemical parameters were recorded.ResultsSingle-factor regression analysis indicated that age, overweight, central adiposity, high low-density lipoprotein cholesterol (LDLC), high total cholesterol (TC), high triglycerides (TG), dyslipidemia, hypertension and low income were the associated factors for knee OA in females; age, high LDLC, hypertension, low income and frequent walking were the associated factors for knee OA in males. Interestingly, male heavy smokers were less likely to develop severe knee OA compared with non-smokers. Stepwise logistic regression analysis indicated that age and overweight were the associated factors for knee OA for all individuals. Although central adiposity, high LDLC, high TC, high TG, dyslipidemia, hypertension and low income appeared to be related to knee OA in females according to univariate analysis, these factors were not identified in stepwise logistic regression analysis. In addition although age, high LDLC, hypertension and frequent walking were also the associated factors for knee OA in males by stepwise logistic regression analysis, smoking as a protective factor was not identified in this analysis.ConclusionsIn this study, aging, obesity, frequent walking, low income and relevant multiple metabolic disorders were the associated factors for knee OA. Smoking might be associated with a lower prevalence of OA in male smokers according to univariate analysis. A retrospective association of smoking with OA may constitute an important etiologic clue, but further well-designed, large-scale prospective controlled trials are required to confirm these findings.

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Section: Methodsmentioning

confidence: 99%

“…Stepwise logistic regression analyses were used to evaluate the factors that were independently associated with OA in the whole population, and separately in women and men; P -values for covariates to be included in the model were set at 0.05. P -values < 0.05 were considered statistically significant, and all tests were two-tailed [ 11 ].…”

Section: Methodsmentioning

confidence: 99%

Prevalence and associated factors of knee osteoarthritis in a rural Chinese adult population: an epidemiological survey

et al. 2015

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“…The method of study population enrollment has been published previously[10],[11]. Briefly, stratified random sampling was used to select a representative sample from the towns of Baqiao and Songqiao in Gaoyou, a city 170 km north of Nanjing, China.…”

Section: Methodsmentioning

confidence: 99%

“…The waist-to-hip ratio was calculated using the smallest circumference at the waist divided by the largest circumference at the hip. For detailed information, refer to our previous study[10],[11].…”

Section: Methodsmentioning

confidence: 99%

Relationship between brachial-ankle pulse wave velocity and metabolic syndrome components in a Chinese population

Zhou¹,

Zhang²,

Yao³

et al. 2014

J Biomed Res

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The purpose of this study was to assess the relationship between arterial stiffness, as measured by brachial-ankle pulse wave velocity (baPWV), and the presence of the metabolic syndrome (MS) in a Chinese population. A total of 4,445 subjects were enrolled. The prevalence of MS in our study population was 21.7%, 17.2% and 25.6% for the general population, males and females, respectively. With adjustments for age, gender, cigarette smoking, heart rate, total cholesterol, low-density lipoprotein (LDL) cholesterol, and the use of anti-hypertensive drug, the stepwise regression analysis showed that baPWV had a significant relationship with components of MS, including systolic blood pressure (P < 0.001), diastolic blood pressure (P < 0.001), glucose (P < 0.001), high-density lipoprotein (HDL) cholesterol (P = 0.04), and triglycerides (P < 0.001), but no relationship with waist circumference (P = 0.25). With an increase in the number of the MS components, baPWV increased significantly both in women and men. This study indicated that the MS is indeed a risk factor for arterial stiffness. Monitoring of baPWV in patients with MS may help in identifying persons at high risk for cardiovascular disease.

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“…Further researches will be needed to confirm our hypothesis, and the important effects of other confounding factors should also be studied. It has been reported that physical activity could modify this genetic effect of the CYBA gene (Zhu et al, 2012). 640A>G polymorphism in the CYBA gene have also been implicated in the development of cardiovascular disease (Goliasch et al, 2011;Xu et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Meta-analysis of C242T polymorphism in CYBA genes: risk of acute coronary syndrome is lower in Asians but not in Caucasians

Huang

et al. 2015

J. Zhejiang Univ. Sci. B

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Background: A lot of studies have demonstrated that C242T polymorphism in CYBA genes may play an important role in the pathological process of acute coronary syndrome (ACS). However, the results are not consistent. To further evaluate this debate, we performed a meta-analysis to determine the relationship between C242T polymorphism and ACS. Methods and results: We screened PubMed/MEDLINE, EBSCIO, and EMBASE research reports until Mar. 2014 and extracted data from 10 studies involving 6102 ACS patients and 8669 controls. Subgroup analysis by ethnicity documented a significant decreased risk of ACS for C242T polymorphism in the Asian population under allelic comparison (odd ratio (OR) 0.73; 95% confidence intervals (CI) 0.64-0.83), dominant model (OR 0.71; 95% CI 0.62-0.82), and homozygote comparison (OR 0.57; 95% CI 0.35-0.92). However, in the overall population and especially with Caucasians, no significant association was uncovered. Further meta-regression analysis revealed that the heterogeneity among studies was largely attributed to ethnicity. No publication bias was detected through a funnel plot and an Egger's linear regression test. Conclusions: Taken together, our results suggest that the C242T polymorphism might be a protective factor against developing ACS in the Asian population. Further researches will be needed to identify the confounding factors which modified the protective effect of T allele among Caucasians.

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Physical activity modifies the association between CYBA gene polymorphisms and small artery elasticity in a Chinese population

Cited by 14 publications

References 32 publications

Prevalence and associated factors of knee osteoarthritis in a rural Chinese adult population: an epidemiological survey

Prevalence and associated factors of knee osteoarthritis in a rural Chinese adult population: an epidemiological survey

Relationship between brachial-ankle pulse wave velocity and metabolic syndrome components in a Chinese population

Meta-analysis of C242T polymorphism in CYBA genes: risk of acute coronary syndrome is lower in Asians but not in Caucasians

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