Relationship between brachial-ankle pulse wave velocity and metabolic syndrome components in a Chinese population

Zhou, Fang; Zhang, Haifeng; Yao, Wenming; Mei, Hongbin; Xu, Duo; Sheng, Yu; Yang, Rong; Kong, Xiangqing; Wang, Liansheng; Zou, Jiangang; Yang, Zhaohui; Li, Xinli

doi:10.7555/jbr.28.20130160

Cited by 10 publications

(4 citation statements)

References 24 publications

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“…Scuteri et al [52] reported the impact of MetS on arterial stiffness to be similar in both sexes, and in this study, the number of MetS components associated with arterial stiffness measures was greater in males. However, baPWV and CAVI increased proportionally as the number of components increased in females, which occurred in other studies conducted on Asian populations [7, 8, 23, 25], but not in males. The different characteristics of the populations analyzed and the arterial stiffness measurement based on different parameters may explain these discrepancies.…”

Section: Discussionmentioning

confidence: 57%

Association of metabolic syndrome and its components with arterial stiffness in Caucasian subjects of the MARK study: a cross-sectional trial

Gómez‐Sánchez¹,

García‐Ortiz

Patino-Alonso

et al. 2016

Cardiovasc Diabetol

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BackgroundThe cardio-ankle vascular index (CAVI) and brachial-ankle pulse wave velocity (baPWV) can reflect both central and peripheral arterial stiffness. Metabolic syndrome (MetS) and its components may increase arterial stiffness and the risk of cardiovascular diseases. However, the correlation of MetS and its components with arterial stiffness is still not clear. The primary aim of this study is thus the relationship using baPWV and CAVI in Caucasian adults with intermediate cardiovascular risk. The secondary aim is to analyze sex differences.MethodsThis study analyzed 2351 subjects aged 35–74 years (mean, 61.4 ± 7.7 years) comprising 61.7 % males and enrolled in the improving interMediAte Risk management (MARK) study. CAVI was measured using a VaSera VS-1500 ® device, and baPWV was calculated using a validated equation. MetS was defined based on the Joint Scientific Statement National Cholesterol Education Program III. Waist circumference, blood pressure, fasting plasma glucose, and lipid profile were measured.ResultsMetS was found in 51.9 % of the subjects. All MetS components except reduced HDL-cholesterol (p = 0.578) were associated with CAVI. High density lipoprotein cholesterol (p = 0.075) and waist circumference (p = 0.315) were associated with baPWV. The different MetS components that assess dyslipidemia using the stiffness measures show different associations according to patient sex. The high blood pressure component had a greater odds ratio (OR) for both baPWV ≥ 17.5 m/sec (OR = 6.90, 95 % CI 3.52–13.519) and CAVI ≥ 9 (OR = 2.20, 95 % CI 1.63–1.90).ConclusionsMetS and all its components (except HDL-cholesterol with baPWV and CAVI and WC with baPWV) were associated with baPWV and CAVI. However, there were sex differences in the association of MetS and its components with baPWV and CAVI. Data from this study suggest a greater association of CAVI and baPWV values with MetS components in males than in females and indicate greater arterial stiffness in the event of simultaneously elevated blood pressure, fasting plasma glucose, and waist circumference. Trial Registration Clinical Trials.gov Identifier: https://clinicaltrials.gov/ct2/show/ NCT01428934. Registered 2 September 2011. Last updated September 8, 2016Electronic supplementary materialThe online version of this article (doi:10.1186/s12933-016-0465-7) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 57%

Association of metabolic syndrome and its components with arterial stiffness in Caucasian subjects of the MARK study: a cross-sectional trial

Gómez‐Sánchez¹,

García‐Ortiz

Patino-Alonso

et al. 2016

Cardiovasc Diabetol

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“…The influencing factors of baPWV are rather complicated. Numbers of metabolic syndrome components, 22 body size phenotypes, 23 ageing and male gender, 24 aerobic exercise and smoking 25 as well as BP control 26 were reported to impact on baPWV. Therefore, evaluating the effect of each factor is difficult to achieve.…”

Section: Discussionmentioning

confidence: 99%

Changes in cardiovascular health score and atherosclerosis progression in middle-aged and older persons in China: a cohort study

et al. 2015

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ObjectivesThe American Heart Association (AHA) proposed a definition of 4 cardiovascular health behaviours and 3 health factors. On the basis of the 7 metrics, the cardiovascular health score (CHS) was used to estimate individual-level changes in cardiovascular health status. The aim of this study was to investigate whether changes in CHS (⊿CHS) at different time-points are associated with atherosclerosis progression in middle-aged and older persons.DesignProspective cohort study in China.SettingsWe defined 8 groups (≤−4, −3, −2, −1, 0, 1, 2 and ≥3) according to ⊿CHS. The impact of ⊿CHS on the change of brachial–ankle pulse wave velocity (⊿baPWV) and atherosclerosis progression was analysed.ParticipantsA total of 3951 individuals met the inclusion criteria (≥40 years old; no history of stroke, transient ischaemic attack or myocardial infarction) and had complete information.Results⊿baPWV decreased gradually (126.46±355.91, 78.4±343.81, 69.6±316.27, 49.59±287.57, 57.07±261.17, 40.45±264.27, 37.45±283.26 and 21.66±264.17 cm/s, respectively) with increasing ⊿CHS (p for trend<0.05). Multivariate linear regression analysis suggested a negative relationship between these 2 variables, which persisted after adjustment for other risk factors. Each increase in CHS was associated with a reduced baPWV for 15.22 cm/s (B value −15.22, p<0.001).Conclusions⊿CHS were negatively related to ⊿baPWV, which proved to be an independent predictor of the progression of atherosclerosis in middle-aged and older persons.Trial registration numberKailuan study (ChiCTR-TNC-11001489).

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“…Metabolic syndrome (MetS) is a pre-atherosclerotic state which involves a cluster of factors, such as abdominal obesity, arterial hypertension, dyslipidemia, and hyperglycemia, and is closely associated with a marked increase in the risk of cardio-cerebrovascular diseases and type 2 diabetes mellitus [1–3]. Some studies have shown that MetS is correlated with arterial stiffness.…”

Section: Introductionmentioning

confidence: 99%

Brachial-ankle pulse wave velocity and metabolic syndrome in general population: the APAC study

Wang

Liu

et al. 2016

BMC Cardiovasc Disord

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BackgroundMetabolic syndrome (MetS) is correlated with arterial stiffness and can be evaluated by brachial-ankle pulse wave velocity (baPWV). We investigated potential associations between MetS and baPWV in a Chinese community population.MethodsThe community-based Asymptomatic Polyvascular Abnormalities in Community study examined asymptomatic polyvascular abnormalities in a Chinese population aged ≥40 years. The relationship between MetS and its components and baPWV was analyzed by multivariate logistic and linear regression models.ResultsOut of 5181 study participants, 1271 subjects (24.53%) had MetS. Mean values of baPWV in subjects with 0, 1, 2,3, 4, and 5 components of MetS were 1430, 1526, 1647, 1676,1740, and 1860 cm/s, respectively (p < 0.001 for trend). After adjusting for confounding risk factors, MetS was significantly associated with baPWV (odds ratio [OR]: 2.74; 95% CI: 2.28, 3.30). Among the five components of MetS, elevated blood pressure was the most important factor for baPWV. All models of multivariate linear regression analysis showed a significant positive correlation between the increasing numbers of MetS components and baPWV (p < 0.0001).ConclusionsbaPWV was associated with MetS and was greater with increasing numbers of MetS components. Elevated blood pressure was the most important factor for baPWV.

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Relationship between brachial-ankle pulse wave velocity and metabolic syndrome components in a Chinese population

Cited by 10 publications

References 24 publications

Association of metabolic syndrome and its components with arterial stiffness in Caucasian subjects of the MARK study: a cross-sectional trial

Association of metabolic syndrome and its components with arterial stiffness in Caucasian subjects of the MARK study: a cross-sectional trial

Changes in cardiovascular health score and atherosclerosis progression in middle-aged and older persons in China: a cohort study

Brachial-ankle pulse wave velocity and metabolic syndrome in general population: the APAC study

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