Physical activity reduces fatigue in patients with cancer and hematopoietic stem cell transplant recipients: A systematic review and meta-analysis of randomized trials

Oberoi, Sapna; Robinson, Paula D.; Cataudella, Danielle; Culos-Reed, S Nicole; Davis, Hailey; Duong, Nathan; Gibson, Faith; Götte, Miriam; Hinds, Pamela S.; Nijhof, Sanne L.; Tomlinson, Deborah; Torre, Patrick van der; Cabral, Sandra; Dupuis, L. Lee; Sung, Lillian

doi:10.1016/j.critrevonc.2017.12.011

Cited by 139 publications

(110 citation statements)

References 37 publications

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“…A large number of studies and meta-analyses confirmed that physical activity (PA) is an effective way to reduce CRF and to increase physical functioning during adjuvant cancer treatment [6][7][8][9]. Only few clinical trials demonstrated positive effects of PA in ACP with CRF [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Fatigue, barriers to physical activity and predictors for motivation to exercise in advanced Cancer patients

et al. 2020

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Background: In order to counteract fatigue, physical activity (PA) is recommended for all stages of cancer. However, only few advanced cancer patients (ACP) are physically active. Quantitative data with high numbers of ACP reporting barriers to PA are missing. This study aimed to identify barriers to PA in ACP with tiredness/weakness and investigate their motivation towards it. Methods: Outpatients with metastatic cancer receiving cancer care at a German Cancer Center reporting moderate/severe tiredness/weakness during self-assessment (MIDOS II) were enrolled. We assessed Fatigue-(FACF-F) and Depression (PHQ8) Scores, demographics, cancer-specific parameters, motivation for PA, physical, psychological and social barriers. Results: 141 of 440 eligible patients (32.0%) with different diagnoses agreed to participate. Patients frequently reported "I feel weakened due to my tumor therapy" (n = 108; 76.6%), physical symptoms (tiredness, weakness, dyspnea, joint-problems, pain, nausea [n = 107; 75.9%]) and fatigue (n = 99; 70.2%) as barriers to PA. However, no significant group differences regarding these barriers were found between physically active and inactive patients. Social barriers were rarely chosen. Motivated patients were 5.6 times more likely to be physically active (p < 0.001), also motivation turned out to be the strongest predictor for a physically active behavior (β = 1.044; p = 0.005). Motivated attitude towards PA was predicted by fatigue (β = − 2.301; p = 0.008), clinically relevant depression (β = − 1.390, p = 0.039), knowledge about PA and quality of life (QoL) (β = 0.929; p = 0.002), PA before diagnosis (β = 0.688; p = 0.005 and Interest in exercise program (β = 0.635; p = 0.008). Conclusion: "I feel weakened due to my tumor therapy" is the most reported barrier to PA among both, physically and inactive patients. Motivation for PA is the strongest predictor of performing PA. Interest in PA, knowledge about PA/ QoL and PA before diagnosis are main predictors of a motivated attitude. Absence/presence of social barriers did not associate with motivation, fatigue and depression proved to be a negative predictor. Programs including information, motivational counseling and individualized training should be offered for ACP to overcome barriers and reduce fatigue.

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Section: Introductionmentioning

confidence: 99%

Fatigue, barriers to physical activity and predictors for motivation to exercise in advanced Cancer patients

et al. 2020

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“… 4 , 10 , 12 , 13 Conversely, physical activity (PA), specifically moderate to vigorous PA (MVPA), has been shown to have a positive effect on CRF in multiple trials in women with BC. 14 , 15 However, a majority of women with BC do not meet the recommended levels of MVPA for various reasons; physical, psychosocial, environmental and organizational factors. 16 - 18 Many people with cancer, including BC, experiencing CRF have reported fatigue as a barrier 19 , 20 to exercise participation, as well as preferences for mild intensity physical activity including yoga.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Yoga Interventions on Cancer-Related Fatigue and Quality of Life for Women with Breast Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

et al. 2020

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Background: Women with breast cancer (BC) are living longer with debilitating side effects such as cancer-related fatigue (CRF) that affect overall well-being. Yoga promotes health, well-being and may be beneficial in reducing CRF. Although there have been previous systematic reviews and meta-analyses, the effects of yoga on CRF and quality of life (QOL) remain unclear, particularly in comparison with other types of physical activity (PA). Our objective is to carry out a systematic review and meta-analysis of the effects of yoga on CRF and QOL in women with BC. Methods: Electronic databases were searched (MEDLINE, Embase Classic+Embase and EMB Reviews, Cochrane Central CT) from inception to May 2018. Randomized controlled trials were included if they were full text, in English, included a yoga intervention, a comparator (including non-PA usual care or alternate PA intervention), and reported on CRF or QOL. Effects of yoga were pooled using standardized mean difference (SMD) via a random effects model. Results: Of the 2468 records retrieved, 24 trials were included; 18 studies compared yoga to a non-PA comparator and 6 to a PA comparator. Yoga demonstrated statistically significant improvements in CRF over non-PA (SMD −0.30 [−0.51; −0.08]) but not PA (SMD −0.17 [−0.50; 0.17]) comparators. Additionally, yoga demonstrated statistically significant improvements in QOL over non-PA (SMD −0.27 [−0.46; −0.07]) but not PA (SMD 0.04 [−0.22; +0.31]) comparators. Discussion: This meta-analysis found that yoga provides small to medium improvements in CRF and QOL compared to non-PA, but not in comparison to other PA interventions.

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“…Priemerná strata hmotnosti bola v intervenčnej skupine 3,50 kg (SD 4,91; 95% CI 2,70 -4,30) a v kontrolnej 0,78 kg (SD predstavuje pohybová aktivita. Cieľom metaanalýzy od Oberoi et al [34] bolo otestovať efektivitu cvičenia u pa cientov s onkologickým ochorením alebo po transplantácii kmeňových buniek kostnej drene. Zahrnuté boli randomizované štúdie.…”

Section: Kolorektálny Karcinóm a Cvičenieunclassified

Physical Therapy as an Adjuvant Treatment for the Prevention and Treatment of Cancer

Líška¹,

Stráska²,

Pupiš³

2020

Klin Onkol

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SouhrnPočet onkologických ochorení má stúpajúcu tendenciu. U pa cientov s onkologickým ochorením je často znížená kvalita života a zhoršená fyzická schopnosť. Cvičenie je zamerané na zlepšenie fyzickej zdatnosti pa cientov a tiež na zlepšenie symptómov spojených s onkologickými ochoreniami, prípadne symptómov spojených s liečbou onkologického ochorenia. Pri cvičení svalové bunky uvoľňujú látky s protektívnym účinkom pred vznikom onkologických ochorení, ktoré sa označujú ako myokíny. Pravidelným cvičením je možné ovplyvniť hodnoty cytokínov IL-2, IL-6, IL-8, TNF-α. Zníženie rizika vzniku onkologického ochorenia pohybovou aktivitou môže byť vysvetlené viacerými mechanizmami, ktoré môžeme rozdeliť na priame a nepriame. Ľudia so zvýšenou pohybovou aktivitou majú zväčša optimálnejšie hodnoty BMI a majú nižší výskyt intraabdominálnej obezity. Medzi ďalšie priame mechanizmy môžeme zaradiť vplyv na hodnoty inzulínu podobného rastového faktora a vazoaktívneho intestinálneho peptidu. Dôležitý mechanizmus tiež predstavuje epigenetický vplyv cvičenia na DNA. Cvičenie pôsobí na oxidačné a antioxidačné dráhy. Cvičenie zohráva dôležitú úlohu v energetickom metabolizme a tiež v ovplyvnení inzulínovej senzitivity. Optimálna pohybová aktivita vedie k redukcii rizika vzniku onkologických ochorení. Cvičenie vedie k zlepšeniu kardiovaskulárneho zdravia u pa cientov s onkologickým ochorením a tiež k optimalizácii hodnôt BMI. Pravidelne cvičenie tiež ovplyvňuje oslabenú svalovú silu u onkologických pa cientov. Cvičenie výrazne ovplyvňuje kvalitu života u onkologických pa cientov. Pre redukciu únavy spojenej s onkologickým ochorením predstavuje cvičenie dôležitú terapeutickú možnosť. Cvičenie rovnako predstavuje benefit pre pa cientov v zlepšení stavu v predoperačnom a pooperačnom období. Cvičenie znižuje riziko komplikácii spojených s operáciou. U pa cientov tiež cvičenie redukuje riziko zranenia u pádov. Kľučové slovápohybová aktivita -cvičenie -onkologické ochorenia Autoři deklarují, že v souvislosti s předmětem studie nemají žádné komerční zájmy.The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.Redakční rada potvrzuje, že rukopis práce splnil ICMJE kritéria pro publikace zasílané do bi omedicínských časopisů.The Editorial Board declares that the manuscript met the ICMJE recommendation for biomedical papers.MUDr. Dávid Líška Fakulta zdravotníctva Slovenská zdravotnícka univerzita v Bratislave Sládkovičova 21 974 05 Banská Bystrica,

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Physical activity reduces fatigue in patients with cancer and hematopoietic stem cell transplant recipients: A systematic review and meta-analysis of randomized trials

Cited by 139 publications

References 37 publications

Fatigue, barriers to physical activity and predictors for motivation to exercise in advanced Cancer patients

Fatigue, barriers to physical activity and predictors for motivation to exercise in advanced Cancer patients

The Effect of Yoga Interventions on Cancer-Related Fatigue and Quality of Life for Women with Breast Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Physical Therapy as an Adjuvant Treatment for the Prevention and Treatment of Cancer

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