Physical Activity Reduces the Effect of High Body Mass Index on Kidney Stones in Diabetes Participants From the 2007–2018 NHANES Cycles: A Cross-Sectional Study

Mao, Weipu; Zhang, Lei; Sun, Si; Wu, Jianping; Zou, Xiangyu; Zhang, Guangyuan; Chen, Ming

doi:10.3389/fpubh.2022.936552

Cited by 12 publications

(6 citation statements)

References 39 publications

(42 reference statements)

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“…NHANES strictly followed the well-designed study protocol, considering the sample weight problem, with good consistency, so the results are widely applicable to the general population in the United States, while our sample size is large enough to conduct relevant subgroup analysis to verify the robustness of the results. Inevitably, however, our study still has some shortcomings: (1) The study has a crosssectional design, so we cannot determine the causal relationship between WWI and the prevalence of kidney stones. (2) Despite our adjustment for possible covariates, confounding due to unknown variables may remain.…”

Section: Discussionmentioning

confidence: 98%

“…Kidney stones are a common urinary disease, accounting for 40–50% of all urinary stone diseases, caused by the abnormal accumulation of crystalline substances in the kidney ( 1 ). The prevalence of kidney stones in developed countries is 5∼15%, the prevalence of kidney stones in China is gradually increasing, the prevalence of adults is 6.4%, and the age of onset is also younger ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

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Study from the United States: increased prevalence of kidney stones in patients with high weight-adjusted waist index

Gui,

Yu,

Chen

et al. 2024

Front. Nutr.

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ObjectiveUsing data from NHANES 2007–2018, to examine the association between WWI (weight-adjusted waist index) index and prevalence of kidney stones.MethodsUsing multiple logistic regression analysis of the National Health and Nutrition Examination Survey (NHANES) 2007–2018, we evaluated the association between WWI index and the prevalence of kidney stones, followed by subgroup analysis of sensitive populations. Smooth curve fitting was used to determine whether there was a non-linear relationship between the WWI index and kidney stone prevalence, and threshold effect analysis was used to test this relationship.ResultsAmong 29,280 participants, 2,760 self-reported renal calculi. After adjustment for all confounders, there was a positive association between WWI and kidney stone prevalence (OR = 1.20, 95% CI: 1.12, 1.28), and this positive association was stronger with increasing WWI (and P = 0.01 for trend). Our results indicate a non-linear positive correlation between WWI index and kidney stones, with the saturation threshold effect analysis and the most important threshold value at 11.02. According to subgroup analysis, WWI showed the strongest association with kidney stone prevalence in participants aged 20–39 years, males, other US ethnic groups, and participants without hypertension and diabetes.ConclusionIncreased WWI is positively associated with increased incidence of kidney stones, and increased WWI is a high risk for kidney stones that should be treated with caution. This association should be more pronounced in people between the ages of 20 and 39 years, in men, in other US ethnic populations, and in participants who do not have hypertension or diabetes.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Study from the United States: increased prevalence of kidney stones in patients with high weight-adjusted waist index

Gui,

Yu,

Chen

et al. 2024

Front. Nutr.

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“…In the same models, differences in percentile units, LDL-C clinical cut points were used to assess the association of RC and LDL-C concordant/discordant groups with kidney stone occurrence. Constrained cubic spline curve functions are frequently applied to describe the dose-response relationships between continuous variables and outcomes [ 24 ]. We applied restricted cubic spline function to describe the dose-response relationship between RC levels and kidney stone risk and adjusting for model variables.…”

Section: Discussionmentioning

confidence: 99%

Relationship between remnant cholesterol and risk of kidney stones in U.S. Adults: a 2007–2016 NHANES analysis

Yao,

Yang

2024

Annals of Medicine

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Purpose Remnant cholesterol (RC) is the cholesterol content of triglyceride-rich lipoproteins. This study aimed to investigate the association between RC levels and kidney stones in U.S. adults. Methods Data were obtained from the 2007 to 2016 National Health and Nutrition Examination Survey (NHANES). A total of 10,551 participants with complete data were included and analyzed in this study. Univariate and multivariate logistic regression analysis, restricted cubic spline function, subgroup analysis and mediation analysis were preformed to estimate the independent relationship between RC levels and kidney stones. Results Participants with stone formation had higher levels of RC than those with without stone formation (25.78 ± 13.83 vs 23.27 ± 13.04, p < 0.001). The results of logistic regression analysis and dose-response risk curves revealed a positive nonlinear association between RC levels and risk of kidney stones [univariate: adjusted odds ratio (aOR) =2.388, 95% CI: 1.797–3.173, p < 0.001; multivariate: aOR = 1.424, 95% CI: 1.050–1.929, p = 0.023]. Compared with the discordantly low RC group, the discordantly high RC group was associated with increased risk of kidney stones (aOR = 1.185, 95% CI: 1.013–1.386, p = 0.034). Similar results were demonstrated according to the discordance of different clinical cut points. And metabolic syndrome parameters and vitamin D levels parallelly mediated the association between RC and kidney stone risk. Conclusions Higher RC levels were independently associated with an increased risk of kidney stone incidence.

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“…Regular exercise and maintaining a healthy weight are also crucial in improving kidney function and reducing the risk of kidney stones. Lastly, avoiding passive smoking is essential in preventing nephrocalcinosis in children with RTA, as smoking can harm the kidneys[ 99 ].…”

Section: Discussionmentioning

confidence: 99%

Renal calcification in children with renal tubular acidosis: What a paediatrician ‎should ‎know‎

Al-Beltagi,

Saeed,

Bediwy

et al. 2023

World J Clin Pediatr

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Renal tubular acidosis (RTA) can lead to renal calcification in children, which can cause various complications and impair renal function. This review provides pediatricians with a comprehensive understanding of the relationship between RTA and renal calcification, highlighting essential aspects for clinical management. The article analyzed relevant studies to explore the prevalence, risk factors, underlying mechanisms, and clinical implications of renal calcification in children with RTA. Results show that distal RTA (type 1) is particularly associated with nephrocalcinosis, which presents a higher risk of renal calcification. However, there are limitations to the existing literature, including a small number of studies, heterogeneity in methodologies, and potential publication bias. Longitudinal data and control groups are also lacking, which limits our understanding of long-term outcomes and optimal management strategies for children with RTA and renal calcification. Pediatricians play a crucial role in the early diagnosis and management of RTA to mitigate the risk of renal calcification and associated complications. In addition, alkaline therapy remains a cornerstone in the treatment of RTA, aimed at correcting the acid-base imbalance and reducing the formation of kidney stones. Therefore, early diagnosis and appropriate therapeutic interventions are paramount in preventing and managing renal calcification to preserve renal function and improve long-term outcomes for affected children. Further research with larger sample sizes and rigorous methodologies is needed to optimize the clinical approach to renal calcification in the context of RTA in the pediatric population.

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Physical Activity Reduces the Effect of High Body Mass Index on Kidney Stones in Diabetes Participants From the 2007–2018 NHANES Cycles: A Cross-Sectional Study

Cited by 12 publications

References 39 publications

Study from the United States: increased prevalence of kidney stones in patients with high weight-adjusted waist index

Study from the United States: increased prevalence of kidney stones in patients with high weight-adjusted waist index

Relationship between remnant cholesterol and risk of kidney stones in U.S. Adults: a 2007–2016 NHANES analysis

Renal calcification in children with renal tubular acidosis: What a paediatrician ‎should ‎know‎

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