Physical Activity to Reduce Systemic Inflammation Associated With Chronic Pain and Obesity

Paley, Carole A; Johnson, Mark I.

doi:10.1097/ajp.0000000000000258

Cited by 64 publications

(51 citation statements)

References 78 publications

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“…34 It was somewhat surprising that changes in physical activity were not associated with greater changes in symptoms, as this has been suggested specifically as a means to improve chronic pain in obesity. 29 It may be that calorie restriction at this level is not conducive to moderate or major increases in physical activity that would show stronger relationships with symptom change. We suspect that the improvements noted in this study are the result of dynamic and complementary factors that will require more assessments to characterize the relevant causal pathways.…”

Section: Discussionmentioning

confidence: 99%

Improvement in the Spatial Distribution of Pain, Somatic Symptoms, and Depression After a Weight Loss Intervention

Schrepf

Harte

Miller

et al. 2017

The Journal of Pain

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Weight loss is known to improve pain localized to weight bearing joints but it is not known how weight loss affects the spatial distribution of pain and associated somatic symptoms like fatigue. We sought to determine if weight loss using a low calorie diet improves pain, affect, and somatic symptoms commonly associated with chronic pain conditions in an observational study. We also documented changes in inflammatory markers in serum before and after weight loss. Participants were 123 obese individuals undergoing a 12–16 week calorie restriction weight loss intervention. The spatial distribution of pain, symptom severity (e.g., fatigue, sleep difficulties), depression, and total fibromyalgia scale scores were measured before and after weight loss. Pain (p =. 022), symptom severity (p = .004), depression (p < .001), and fibromyalgia scores (p= .004) improved following weight loss; men showed greater improvement than women on somatic symptoms and fibromyalgia scores (both p < .01). Those who lost at least 10% of body weight showed greater improvement than those who lost less than 10%. Levels of the regulatory cytokine Interleukin-10 increased following the intervention (p = .002). Weight loss may improve diffuse pain and comorbid symptoms commonly seen in chronic pain participants.

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Section: Discussionmentioning

confidence: 99%

Improvement in the Spatial Distribution of Pain, Somatic Symptoms, and Depression After a Weight Loss Intervention

Schrepf

Harte

Miller

et al. 2017

The Journal of Pain

View full text Add to dashboard Cite

show abstract

“…Meta-analysis was not possible and we concluded that there was insufficient evidence to determine whether differences in pain sensitivity response between obese and non-obese individuals exist. This finding is inconsistent with the increased pain sensitivity response expected if a low-grade pro-inflammatory state existed in obese individuals (McVinnie, 2013;Paley and Johnson, 2015). They found that obese participants had decreased sensitivity, higher thresholds and lower subjective ratings for painful and non-painful thermal stimuli on the abdomen when compared with non-obese participants.…”

Section: Introductionmentioning

confidence: 91%

“…In addition, they suggested that reduced thermal conductivity associated with excess subcutaneous fat may hinder the transmission of temperature changes to thermal and nociceptive fibres in obese individuals. This finding is inconsistent with the increased pain sensitivity response expected if a low-grade pro-inflammatory state existed in obese individuals (McVinnie, 2013;Paley and Johnson, 2015). Price et al (2013) suggested that it was possible that an increased ratio of antiinflammatory:pro-inflammatory molecules in obese adipose tissue could result in locally decreased pain sensitivity.…”

Section: Introductionmentioning

confidence: 92%

Body mass index and distribution of body fat can influence sensory detection and pain sensitivity

Tashani

Astita

Sharp

et al. 2017

European Journal of Pain

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This study provided evidence that body mass index and distribution of body fat can influence sensory detection and pain sensitivity. Obese individuals were more sensitive than normal range body mass index individuals to pressure pain but not to thermal pain. Pain response varied according to subcutaneous body fat at different body sites. These findings strengthen arguments that weight loss should be a significant aspect of a pain management programme for obese pain patients.

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“…Overall, however, the chronic effects of exercise on inflammation are still viewed as beneficial to reduce inflammatory signaling in disease (Ploeger et al, 2009). For this reason, exercise has been utilized as an intervention that can activate this natural anti-inflammatory mechanism that causes cells to secrete anti-inflammatory cytokines that suppress the pain induced by pro-inflammatory cytokines (Paley and Johnson, 2015). …”

Section: The Relationship Of Inflammation and Exercisementioning

confidence: 99%

Emerging Relationships between Exercise, Sensory Nerves, and Neuropathic Pain

2016

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The utilization of physical activity as a therapeutic tool is rapidly growing in the medical community and the role exercise may offer in the alleviation of painful disease states is an emerging research area. The development of neuropathic pain is a complex mechanism, which clinicians and researchers are continually working to better understand. The limited therapies available for alleviation of these pain states are still focused on pain abatement and as opposed to treating underlying mechanisms. The continued research into exercise and pain may address these underlying mechanisms, but the mechanisms which exercise acts through are still poorly understood. The objective of this review is to provide an overview of how the peripheral nervous system responds to exercise, the relationship of inflammation and exercise, and experimental and clinical use of exercise to treat pain. Although pain is associated with many conditions, this review highlights pain associated with diabetes as well as experimental studies on nerve damages-associated pain. Because of the global effects of exercise across multiple organ systems, exercise intervention can address multiple problems across the entire nervous system through a single intervention. This is a double-edged sword however, as the global interactions of exercise also require in depth investigations to include and identify the many changes that can occur after physical activity. A continued investment into research is necessary to advance the adoption of physical activity as a beneficial remedy for neuropathic pain. The following highlights our current understanding of how exercise alters pain, the varied pain models used to explore exercise intervention, and the molecular pathways leading to the physiological and pathological changes following exercise intervention.

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Physical Activity to Reduce Systemic Inflammation Associated With Chronic Pain and Obesity

Cited by 64 publications

References 78 publications

Improvement in the Spatial Distribution of Pain, Somatic Symptoms, and Depression After a Weight Loss Intervention

Improvement in the Spatial Distribution of Pain, Somatic Symptoms, and Depression After a Weight Loss Intervention

Body mass index and distribution of body fat can influence sensory detection and pain sensitivity

Emerging Relationships between Exercise, Sensory Nerves, and Neuropathic Pain

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