The South American Andes hide countless cacti and are part of valuable Andean biodiversity. Within this large family of Cactaceae are edible cacti that are highly valued for their medicinal properties and used as edible fruits. In this review, we will make a description of the overall chemical composition, main phytochemicals found in some edible cacti of the Andean region such as sanky (Corryocactus brevistylus), pitahaya (Hylocereus monacanthus, Hylocereus megalanthus) and tuna or prickly pear (Opuntia ficus-indica). In addition, we will include its medicinal and therapeutic properties and its commercial applications and uses as a natural colorant.