Physical and Chemical Characterisation of Acrylamide-Based Hydrogels, Aam, Aam/NaCMC and Aam/NaCMC/MgO

Sabbagh, Farzaneh; Muhamad, Ida Idayu

doi:10.1007/s10904-017-0599-4

Cited by 31 publications

(20 citation statements)

References 50 publications

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“…Calibration was achieved using a series of near-monodisperse polystyrene standards for diblock copolymers. All diblock copolymers were modified via Steglich esterification [30] using methanol as methylation agent to avoid COOH group interactions with SEC columns [31]. To avoid post modification of the polymer, polymer solutions were also prepared in THF with 5 wt% TFA.…”

Section: General Methodsmentioning

confidence: 99%

Synthesis of Poly(methacrylic acid)-block-Polystyrene Diblock Copolymers at High Solid Contents via RAFT Emulsion Polymerization

et al. 2021

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The combination of polymerization–induced self-assembly (PISA) and reversible–addition fragmentation chain transfer (RAFT) emulsion polymerization offers a powerful technique to synthesize diblock copolymers and polymeric nanoparticles in a controlled manner. The RAFT emulsion diblock copolymerization of styrene and methacrylic acid (MAA) by using a trithiocarbonate as surfactant and RAFT agent was investigated. The Z-group of the RAFT agent was modified with a propyl-, butyl- and dodecyl- sidechain, increasing the hydrophobicity of the RAFT agent to offer well-controlled polymerization of poly(methacrylic acid)-block-polystyrene (PMAA-b-PS) diblock copolymers at high solid contents between 30–50 wt% in water. The kinetic data of the PMAA homopolymerization with the three different RAFT agents for various solvents was investigated as well as the RAFT emulsion polymerization of the diblock copolymers in pure water. While the polymerization of PMAA-b-PS with a propyl terminus as a Z-group suffered from slow polymerization rates at solid contents above 30 wt%, the polymerization with a dodecyl sidechain as a Z-group led to full conversion within 2 h, narrow molar mass distributions and all that at a remarkable solid content of up to 50 wt%.

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Section: General Methodsmentioning

confidence: 99%

Synthesis of Poly(methacrylic acid)-block-Polystyrene Diblock Copolymers at High Solid Contents via RAFT Emulsion Polymerization

et al. 2021

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“…Both the concentration of iron ions and the alkali utilized increase the yield of the product (MNPs) [ 103 ]. Nagireddy et al reported composite MHGs obtained via an in situ coprecipitation method where the hydrogel matrix was gum-acacia-grafted polyacrylamide [ 104 , 105 ]. Semi-interpenetrating hydrogel (semi-IPN) was also created, in which Fe 3 O 4 MNPs were deposited in situ in a poly(N-isopropyl acrylamide) matrix [ 106 ].…”

Section: Fabrication Of Magnetic Hydrogelsmentioning

confidence: 99%

Design of Magnetic Hydrogels for Hyperthermia and Drug Delivery

Ganguly

Margel

2021

Polymers

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Hydrogels are spatially organized hydrophilic polymeric systems that exhibit unique features in hydrated conditions. Among the hydrogel family, composite hydrogels are a special class that are defined as filler-containing systems with some tailor-made properties. The composite hydrogel family includes magnetic-nanoparticle-integrated hydrogels. Magnetic hydrogels (MHGs) show magneto-responsiveness, which is observed when they are placed in a magnetic field (static or oscillating). Because of their tunable porosity and internal morphology they can be used in several biomedical applications, especially diffusion-related smart devices. External stimuli may influence physical and chemical changes in these hydrogels, particularly in terms of volume and shape morphing. One of the most significant external stimuli for hydrogels is a magnetic field. This review embraces a brief overview of the fabrication of MHGs and two of their usages in the biomedical area: drug delivery and hyperthermia-based anti-cancer activity. As for the saturation magnetization imposed on composite MHGs, they are easily heated in the presence of an alternating magnetic field and the temperature increment is dependent on the magnetic nanoparticle concentration and exposure time. Herein, we also discuss the mode of different therapies based on non-contact hyperthermia heating.

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“…The expression of pro-inflammatory cytokines such as TNF-α and IL-1β was lower with hybrid hydrogels ( p < 0.05). This reduction in expression of inflammatory cytokines may have a positive effect on enhancing the healing rate at the implantation site [ 309 ]. Finally, digital light projection (DLP)-based 3D printing was used to create models of newborn vasculature utilizing this generated hybrid hydrogel.…”

Section: Applications Of 4d Printed Hydrogelsmentioning

confidence: 99%

Smart and Biomimetic 3D and 4D Printed Composite Hydrogels: Opportunities for Different Biomedical Applications

et al. 2021

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In recent years, smart/stimuli-responsive hydrogels have drawn tremendous attention for their varied applications, mainly in the biomedical field. These hydrogels are derived from different natural and synthetic polymers but are also composite with various organic and nano-organic fillers. The basic functions of smart hydrogels rely on their ability to change behavior; functions include mechanical, swelling, shaping, hydrophilicity, and bioactivity in response to external stimuli such as temperature, pH, magnetic field, electromagnetic radiation, and biological molecules. Depending on the final applications, smart hydrogels can be processed in different geometries and modalities to meet the complicated situations in biological media, namely, injectable hydrogels (following the sol-gel transition), colloidal nano and microgels, and three dimensional (3D) printed gel constructs. In recent decades smart hydrogels have opened a new horizon for scientists to fabricate biomimetic customized biomaterials for tissue engineering, cancer therapy, wound dressing, soft robotic actuators, and controlled release of bioactive substances/drugs. Remarkably, 4D bioprinting, a newly emerged technology/concept, aims to rationally design 3D patterned biological matrices from synthesized hydrogel-based inks with the ability to change structure under stimuli. This technology has enlarged the applicability of engineered smart hydrogels and hydrogel composites in biomedical fields. This paper aims to review stimuli-responsive hydrogels according to the kinds of external changes and t recent applications in biomedical and 4D bioprinting.

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Physical and Chemical Characterisation of Acrylamide-Based Hydrogels, Aam, Aam/NaCMC and Aam/NaCMC/MgO

Cited by 31 publications

References 50 publications

Synthesis of Poly(methacrylic acid)-block-Polystyrene Diblock Copolymers at High Solid Contents via RAFT Emulsion Polymerization

Synthesis of Poly(methacrylic acid)-block-Polystyrene Diblock Copolymers at High Solid Contents via RAFT Emulsion Polymerization

Design of Magnetic Hydrogels for Hyperthermia and Drug Delivery

Smart and Biomimetic 3D and 4D Printed Composite Hydrogels: Opportunities for Different Biomedical Applications

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