Physical and chemical properties of carbon dots

“…As CNDs and oxCNDs possess extremely appealing physicochemical properties (biocompatibility, hydrophilicity, chemical stability, electroconductivity, high reactivity, surface functionality, and low toxicity), 27 more research on this aspect is necessary to explore their use in biomedical applications. In this study, we aimed to compare GO and oxCNDs as carriers of quercetin, a potent flavonoid found mainly in vegetables and fruits, which is characterized by its antioxidant, anti-inflammatory, anti-atherosclerotic, anti-hypertensive, and anti-cancer properties.…”

Section: Introductionmentioning

confidence: 99%

Graphene oxide and oxidized carbon nanodiscs as biomedical scaffolds for the targeted delivery of quercetin to cancer cells

Zygouri,

Tsiodoulos,

Angelidou

et al. 2024

Nanoscale Adv.

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CARBON DOTS: Bioimaging and Anticancer Drug Delivery

Bartkowski,

Zhou,

Nabil Amin Mustafa

et al. 2024

Chemistry A European J

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Cancer, responsible for approximately 10 million lives annually, urgently requires innovative treatments, as well as solutions to mitigate the limitations of traditional chemotherapy, such as long‐term adverse side effects and multidrug resistance. This review focuses on Carbon Dots (CDs), an emergent class of nanoparticles (NPs) with remarkable physicochemical and biological properties, and their burgeoning applications in bioimaging and as nanocarriers in drug delivery systems for cancer treatment. The review initiates with an overview of NPs as nanocarriers, followed by an in‐depth look into the biological barriers that could affect their distribution, from barriers to administration, to intracellular trafficking. It explores CDs' synthesis, both bottom‐up and top‐down approaches, and their notable biocompatibility, supported by a selection of in vitro, in vivo, and ex vivo studies. Special attention is given to CDs' role in bioimaging, highlighting their optical properties. The discussion extends to their emerging significance as drug carriers, particularly in the delivery of doxorubicin and other anticancer agents, underscoring recent advancements and challenges in this field with examples of other promising bioapplications, emergent owing to the NPs flexible design. As research on CDs evolves, we envisage key challenges, as well as the potential of CD‐based systems in bioimaging and cancer therapy.

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Physical and chemical properties of carbon dots

Cited by 5 publications

References 40 publications

An insight into the role of carbon dots in the agriculture system: a review

An insight into the role of carbon dots in the agriculture system: a review

Graphene oxide and oxidized carbon nanodiscs as biomedical scaffolds for the targeted delivery of quercetin to cancer cells

CARBON DOTS: Bioimaging and Anticancer Drug Delivery

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