Physical and Chemical Stability Test of SNEDDS (Self-nanoemulsifying Drug Delivery System) and Nanoemulsion Ethyl Acetate Fraction of  Garcinia mangostana L.

Pratiwi, Liza; Fudholi, Achmad; Martien, Ronny; Pramono, Suwijiyo

doi:10.22146/mot.28533

Cited by 18 publications

(19 citation statements)

References 5 publications

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“…Mixtures of extract and oil were stored at 26–27°C for 5 days to visually observe the presence of undissolved extract in oil. Solubility data of mangosteen extract in VCO, reported by Pratiwi et al [ 17 ], was available for comparison purposes.…”

Section: Methodsmentioning

confidence: 99%

Nanoemulsions containing Garcinia mangostana L. pericarp extract for topical applications: Development, characterization, and in vitro percutaneous penetration assay

2021

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A highly stable oil-in-water nanoemulsion for topical applications, containing mangostins extracted from the pericarp of mangosteen (Garcinia mangostana L.), is a promising strategy to protect mangostins as well as to improve penetration of these important antioxidants through the skins. Nanoemulsions consisted of virgin coconut oil as the oil phase, Tween-80 and Span-80 as surfactants, and xanthan gum as the thickening agent, were prepared using the high-energy and low-energy emulsification methods. The nanoemulsions that were stable up to 28 days had oil droplet diameter of 220 nm to 353 nm and zeta potential of -46.9 mV to -63.7 mV. The accelerated stability test showed that the most stable nanoemulsions were those prepared using the low-energy emulsification method with an estimated shelf life of eleven months, composed of 11% oil phase, 17% surfactant, and 72% aqueous phase. The in vitro percutaneous penetration test for the nanoemulsion with added xanthan gum provided high cumulative skin penetration of mangostins of up to 114 μg/cm2. The results of this study indicate that virgin coconut oil-based nanoemulsions containing mangostins, prepared using the low-energy emulsification method, stabilized by xanthan gum and mixed at 40°C can prospectively be used for topical applications.

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Section: Methodsmentioning

confidence: 99%

Nanoemulsions containing Garcinia mangostana L. pericarp extract for topical applications: Development, characterization, and in vitro percutaneous penetration assay

2021

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“…This value can improve the decreasing of surface tension between oil and water. PEG 400 as co-surfactants can increase the surface fluidity through penetration way to surfactants film that can create a free space between the surfactants molecules (Pratiwi et al, 2018). Nanoemulsion of ethanolic mangosteen leaves extract can be shown on Figure 1.…”

Section: Formulation Of Self Nanemulsifying Drug Delivery System (Snedds)mentioning

confidence: 99%

Antibacterial (Staphylococcus aureus and Escherichia coli) and Antifungal (Saccharomyces cerevisiae) Activity Assay on Nanoemulsion Formulation of Ethanol Extract of Mangosteen Leaves (Garcinia mangostana L.) as Fruit Preservative

Diniatik

Anggraeni

2021

J. Food Pharm. Sci

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Fruits after harvesting will decay faster if not handled properly. Fruits can be demaged by bacterial and fungal. Mangosteen leaves contain xanthons which are antibacterial and antifungal. 50% ethanol extract of mangosteen leaves is formulated in Nanoemulsion preparations using the SNEDDS (Self-Nanoemulsifying Drug Delivery System) method. The mangosteen leaves 50% ethanol extract nanoemulsion formulation consisted of VCO (Virgin Coconut Oil) as oil, tween 80 as surfactant, and PEG 400 as cosurfactant. There are 3 formulations with variations in the concentration of mangosteen leaves ethanol extract, there are concentrations of 1%, 2%, and 3%. All formulations have a T% of more than 90%. The results of the particles measurement of nanoemulsion using PSA were in formulation 1 amounting to 16.1 nm; formula 2 is 16.7 nm; and formula 3 is 16.6 nm. The zeta potential characterization shows that formula 1 has a zeta value of -40.9 mV. The three formulations had a pH of 5. The largest inhibitory zone in the mangosteen leaf ethanol extract against S.aureus and E. coli bacteria were 11.08 mm and 5.87 mm respectively. Whereas in the S. cerevisiae antifungal test there was no inhibition zone at all concentrations. In the antibacterial and antifungal tests nanoemulsion preparations did not produce inhibitory zones in each concentration. Nanoemulsion preparations can retain the quality of strawberries when compared to the non-nanoemulsion preservative group, both in room storage and refrigerator temperature. The best preservative result is when the fruit is coated with nanoemulsion preservative and stored in refrigerator temperature.

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“…The surface charge of nanoemulsion with nonionic surfactant comes from the adsorption of ions in the water phase or due to droplets friction with its dispersing medium. The adsorbed ions on the droplets surface produce an electric double layer resulting a repulsive force among the particles, thus it prevents aggregation [42]. Moreover, dye test showed that all ginger oil nanoemulsions type were O/W ( Figure 6).…”

Section: Characterization Of Optimum Nanoemulsion Formulasmentioning

confidence: 99%

“…It was characterized by uniform dispersion of methylene blue mainly in water phase. O/W nanoemulsion with nonionic surfactant results a film layer on the droplets surface preventing droplets integration in the dispersing medium [42].…”

Section: Characterization Of Optimum Nanoemulsion Formulasmentioning

confidence: 99%

The formulation of ginger oil nanoemulsions of three varieties of ginger (Zingiber officinale Rosc.) as natural antioxidant

Ningsih¹,

Faradisa²,

Cahyani³

et al. 2020

JRP

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One of traditional plants in Indonesia that could be potentially developed as antioxidant is ginger (Zingiber officinale Rosc.). There are three varieties, namely elephant ginger, yellow ginger, and red ginger. Its contents mainly essential oil consisted of many antioxidant compounds. Nevertheless, the use of ginger oil in topical dosage form formula is less effective, unstable, and volatile which affects its bioavailability. In this study, nanoemulsion formulas of ginger oil were optimized according to the ratio of tween 80 as surfactant and ethanol as cosurfactant using simplex lattice design (SLD) method. The optimum nanoemulsion formulas of each varieties were characterized and the result showed that nanoemulsion of yellow ginger oil had the highest percentage transmittance (99.676 ± 0.096%) and halfmaximal inhibitory concentration (IC50) value (3.010 ± 0.008 mg/mL). Furthermore, all optimum formulas had complied the other nanoemulsion specifications. The study indicated that nanoemulsion formulas of three varieties of ginger essential oils could be developed as potential antioxidant agent.

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Physical and Chemical Stability Test of SNEDDS (Self-nanoemulsifying Drug Delivery System) and Nanoemulsion Ethyl Acetate Fraction of Garcinia mangostana L.

Cited by 18 publications

References 5 publications

Nanoemulsions containing Garcinia mangostana L. pericarp extract for topical applications: Development, characterization, and in vitro percutaneous penetration assay

Nanoemulsions containing Garcinia mangostana L. pericarp extract for topical applications: Development, characterization, and in vitro percutaneous penetration assay

Antibacterial (Staphylococcus aureus and Escherichia coli) and Antifungal (Saccharomyces cerevisiae) Activity Assay on Nanoemulsion Formulation of Ethanol Extract of Mangosteen Leaves (Garcinia mangostana L.) as Fruit Preservative

The formulation of ginger oil nanoemulsions of three varieties of ginger (Zingiber officinale Rosc.) as natural antioxidant

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