Physical and Chemical Strategies for Therapeutic Delivery by Using Polymeric Nanoparticles

Morachis, José M.; Mahmoud, E. A.; Almutairi, Adah

doi:10.1124/pr.111.005363

Cited by 204 publications

(155 citation statements)

References 120 publications

Supporting

Mentioning

149

Contrasting

Unclassified

Order By: Relevance

“…[1][2][3] This interest partly stems from their higher thermodynamic and kinetic stabilities compared to assemblies obtained from low molecular weight surfactant analogs, which in turn results in their much higher critical aggregation concentrations. 4,5 In addition, the development of controlled living polymerization methods at the molecular level has enabled access to a diverse range of BCP assemblies.…”

Section: Introductionmentioning

confidence: 99%

“…In this context, the shape, size, and rigidity of nanoparticulate therapeutic agents play a key role in determining their uptake efficiency, circulation time, and distribution in the body. 2 Although the optimal parameters vary according to the specific application, non-spherical structures such as one-dimensional (1D) particles appear to have a very promising role to play. 2,[17][18][19] Specifically, it has been shown that blood circulation times of polydisperse BCP cylinders were longer than comparable spherical nanoparticles and the values increased with micelle length.…”

Section: Introductionmentioning

confidence: 99%

“…2 Although the optimal parameters vary according to the specific application, non-spherical structures such as one-dimensional (1D) particles appear to have a very promising role to play. 2,[17][18][19] Specifically, it has been shown that blood circulation times of polydisperse BCP cylinders were longer than comparable spherical nanoparticles and the values increased with micelle length. 17 In addition, rod-like particles offer better cell uptake rates and extents in human melanoma cells compared to spherical particles.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Monodisperse Cylindrical Micelles and Block Comicelles of Controlled Length in Aqueous Media

et al. 2016

View full text Add to dashboard Cite

Cylindrical block copolymer micelles have shown considerable promise in various fields of biomedical research. However, unlike spherical micelles and vesicles, control over their dimensions in biologically-relevant solvents has posed a key challenge that potentially limits in depth studies and their optimisation for applications. Here, we report the preparation of cylindrical micelles of length in the wide range of 40 nm -1.10 µm in aqueous media with narrow length distributions (length polydispersities < 1.10). In our approach, an amphiphilic linear-brush block copolymer, with high potential for functionalization, was synthesized based on poly(ferrocenyldimethylsilane)-b-poly(allyl glycidyl ether) (PFS-b-PAGE) decorated with triethylene glycol (TEG), abbreviated as PFS-b-(PEO-g-TEG). PFS-b-(PEO-g-TEG) cylindrical micelles of controlled length with low polydispersities were prepared in N,N-dimethylformamide using small seed initiators via living crystallization-driven self-assembly. Successful dispersion of these micelles into aqueous media was achieved by dialysis against deionized water. Furthermore, B-A-B amphiphilic triblock comicelles with PFS-b-poly(2-vinylpyridine) (P2VP) as hydrophobic "B" blocks and hydrophilic PFS-b-(PEO-g-TEG) "A" segments were prepared and their hierarchical self-assembly in aqueous media studied. It was found that superstructures formed depend on the length of the hydrophobic blocks. Quaternization of P2VP was shown to cause the disassembly of the superstructures, resulting in the first examples of water-soluble cylindrical multi-block comicelles. We also demonstrate the ability of the triblock comicelles with quaternized terminal segments to complex DNA and, thus, to potentially function as gene vectors.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Monodisperse Cylindrical Micelles and Block Comicelles of Controlled Length in Aqueous Media

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Additionally new approaches based in fluorescent labelled DDS are used for identification of dysplasia by molecular imaging [49]. The prof-of-principle of targeting and drug release is being investigated by attaching antibodies to DDS [50] and by applying radiation [51,52] or by thermal effects in the tissues [53,54]. Nanosystems like dendrimers, liposomes, niosomes, metal based NPs, micelles, nanoemulsions, quantum dots and polymer NPs have been developed (Table 2).…”

Section: Drug Delivery Systemsmentioning

confidence: 99%

Supramolecular nanoscale assemblies for cancer diagnosis and therapy

Coelho

Pereira

Juzeniene

et al. 2015

Journal of Controlled Release

View full text Add to dashboard Cite

Nanocarriers based on polymers, metals and lipids have been extensively developed for cancer therapy and diagnosis due to their ability to enhance drug accumulation in cancer cells and decrease undesired drug toxicity in healthy tissues. Overcoming multidrug resistance by designing proper drug nanocarriers will improve outcome of existing oncologic treatments such as chemotherapy or radiotherapy. In this article the relation between physicochemical properties and capacity of a nanosystem to deliver therapeutic agents into pathological sites is discussed. Most promising examples of drug delivery systems are reviewed, and, in particular, the design of a carbohydrate based matrix with entrapped gold nanoparticles is highlighted.

show abstract

“…The reason why light has emerged as one of the most promising alternatives is that its application can be spatial and timed controlled with ease. 9 Since ultraviolet (UV) light has the highest power and can break bonds more easily than other radiations, it has been by far the most widely used radiation to trigger drug release from stimuli-responsive devices. [10][11][12][13] However, UV light has substantial drawbacks for in vitro and in vivo experiments and therefore for current medical applications.…”

Section: Introductionmentioning

confidence: 99%