Physical and mechanical regulation of macrophage phenotype and function

McWhorter, Frances Y.; Davis, Chase T.; Liu, Wendy F.

doi:10.1007/s00018-014-1796-8

Cited by 372 publications

(372 citation statements)

References 107 publications

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“…5c). The slowly accumulating insight into the molecular mechanisms of the mechano sensing 23,[104][105][106] will allow drugable, pharmacological targets to be identified in order to better avoid FBR-causing mechanosensitivity of cells in contact with an implant. Slow release of suitable agonists could then be built into the implant surface to mechanically silence the cells in contact with it (that is, pharmacological stealthing of the implant).…”

Section: Engineering the Local Mechanical Microenvironmentmentioning

confidence: 99%

Materials and technologies for soft implantable neuroprostheses

2016

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| Implantable neuroprostheses are engineered systems designed to restore or substitute function for individuals with neurological deficits or disabilities. These systems involve at least one uni-or bidirectional interface between a living neural tissue and a synthetic structure, through which information in the form of electrons, ions or photons flows. Despite a few notable exceptions, the clinical dissemination of implantable neuroprostheses remains limited, because many implants display inconsistent long-term stability and performance, and are ultimately rejected by the body. Intensive research is currently being conducted to untangle the complex interplay of failure mechanisms. In this Review, we emphasize the importance of minimizing the physical and mechanical mismatch between neural tissues and implantable interfaces. We explore possible materials solutions to design and manufacture neurointegrated prostheses, and outline their immense therapeutic potential. NATURE REVIEWS | MATERIALSADVANCE ONLINE PUBLICATION | 1 REVIEWS© 2 0 1 6 M a c m i l l a n P u b l i s h e r s L i m i t e d , p a r t o f S p r i n g e r N a t u r e . A l l r i g h t s r e s e r v e d .

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Section: Engineering the Local Mechanical Microenvironmentmentioning

confidence: 99%

Materials and technologies for soft implantable neuroprostheses

2016

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“…Studies have demonstrated that TLR4 and IFN-γ receptors on the macrophage can interact with the M1 activation signal, while IL-10R and IL-4R respond to the M2 activation signal [41]. Signaling pathways involved in macrophage polarization have been investigated (Figure 1).…”

Section: Macrophage Polarizationmentioning

confidence: 99%

The Current State of Nanoparticle-Induced Macrophage Polarization and Reprogramming Research

Miao

Leng

Zhang

2017

IJMS

166

122

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Macrophages are vital regulators of the host defense in organisms. In response to different local microenvironments, resting macrophages (M0) can be polarized into different phenotypes, pro-inflammatory (M1) or anti-inflammatory (M2), and perform different roles in different physiological or pathological conditions. Polarized macrophages can also be further reprogrammed by reversing their phenotype according to the changed milieu. Macrophage polarization and reprogramming play essential roles in maintaining the steady state of the immune system and are involved in the processes of many diseases. As foreign substances, nanoparticles (NPs) mainly target macrophages after entering the body. NPs can perturb the polarization and reprogramming of macrophages, affect their immunological function and, therefore, affect the pathological process of disease. Optimally-designed NPs for the modulation of macrophage polarization and reprogramming might provide new solutions for treating diseases. Systematically investigating how NPs affect macrophage polarization is crucial for understanding the regulatory effects of NPs on immune cells in vivo. In this review, macrophage polarization by NPs is summarized and discussed.

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“…However, these macrophages exhibited a low expression of Arg1, which is not consistent with a typical M2 phenotype [107]. The discrepancies in these studies may be due to the inherent differences of the cell lines used in each study since macrophages from different species or anatomical sites are known to behave differently [108]. …”

Section: Biomaterials Strategies To Manipulate M1 Vs M2 Differentimentioning

confidence: 99%

Delivery strategies to control inflammatory response: Modulating M1–M2 polarization in tissue engineering applications

Álvarez

Liu

Santiago

et al. 2016

Journal of Controlled Release

201

119

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Macrophages are key players in many physiological scenarios including tissue homeostasis. In response to injury, typically the balance between macrophage sub-populations shifts from an M1 phenotype (pro-inflammatory) to an M2 phenotype (anti-inflammatory). In tissue engineering scenarios, after implantation of any device, it is desirable to exercise control on this M1-M2 progression and to ensure a timely and smooth transition from the inflammatory to the healing stage. In this review, we briefly introduce the current state of knowledge regarding macrophage function and nomenclature. Next, we discuss the use of controlled release strategies to tune the balance between the M1 and M2 phenotypes in the context of tissue engineering applications. We discuss recent literature related to the release of anti-inflammatory molecules (including nucleic acids) and the sequential release of cytokines to promote a timely M1-M2 shift. In addition, we describe the use of macrophages as controlled release agents upon stimulation by physical and/or mechanical cues provided by scaffolds. Moreover, we discuss current and future applications of “smart” implantable scaffolds capable of controlling the cascade of biochemical events related to healing and vascularization. Finally, we provide our opinion on the current challenges and the future research directions to improve our understanding of the M1-M2 macrophage balance and properly exploit it in tissue engineering and regenerative medicine applications.

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Physical and mechanical regulation of macrophage phenotype and function

Cited by 372 publications

References 107 publications

Materials and technologies for soft implantable neuroprostheses

Materials and technologies for soft implantable neuroprostheses

The Current State of Nanoparticle-Induced Macrophage Polarization and Reprogramming Research

Delivery strategies to control inflammatory response: Modulating M1–M2 polarization in tissue engineering applications

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