The Current State of Nanoparticle-Induced Macrophage Polarization and Reprogramming Research

Miao, Xiaoyuan; Leng, Xigang; Zhang, Qiu

doi:10.3390/ijms18020336

Cited by 167 publications

(134 citation statements)

References 58 publications

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“…Research groups have also shown that within the tumor microenvironment, liposomes can polarize tumor-associated macrophages (TAMs) [107][108][109]. The reprogramming of classically activated (M1) TAMs, which have a role in eradicating tumor cells in their early stages, to alternatively activated M2-like TAMs has been shown to promote tumor growth and metastasis, as shown in Figure 2 [110,111]. In an orthotopic ovarian carcinoma (ID8-VEGF-GFP) mouse model, La-Beck et al showed that empty liposomes increased tumor volume by over 3-fold and doubled the number of metastatic sites, compared to the vehicle control [107].…”

Section: Interactions With the Mononuclear Phagocyte Systemmentioning

confidence: 99%

Immunological and Toxicological Considerations for the Design of Liposomes

et al. 2020

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Liposomes hold great potential as gene and drug delivery vehicles due to their biocompatibility and modular properties, coupled with the major advantage of attenuating the risk of systemic toxicity from the encapsulated therapeutic agent. Decades of research have been dedicated to studying and optimizing liposomal formulations for a variety of medical applications, ranging from cancer therapeutics to analgesics. Some effort has also been made to elucidate the toxicities and immune responses that these drug formulations may elicit. Notably, intravenously injected liposomes can interact with plasma proteins, leading to opsonization, thereby altering the healthy cells they come into contact with during circulation and removal. Additionally, due to the pharmacokinetics of liposomes in circulation, drugs can end up sequestered in organs of the mononuclear phagocyte system, affecting liver and spleen function. Importantly, liposomal agents can also stimulate or suppress the immune system depending on their physiochemical properties, such as size, lipid composition, pegylation, and surface charge. Despite the surge in the clinical use of liposomal agents since 1995, there are still several drawbacks that limit their range of applications. This review presents a focused analysis of these limitations, with an emphasis on toxicity to healthy tissues and unfavorable immune responses, to shed light on key considerations that should be factored into the design and clinical use of liposomal formulations.

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Section: Interactions With the Mononuclear Phagocyte Systemmentioning

confidence: 99%

Immunological and Toxicological Considerations for the Design of Liposomes

et al. 2020

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“…Cytoskeletal staining showed that ACP NPs reported that nano-porous microstructures mediate osteogenesis by modulating the osteo-immune response of macrophages [34] . An immune microenvironment induced by Cu-MSNs led to robust osteogenic differentiation of BMSCs via the activation of the oncostatin M (OSM) pathway [24] . The surface chemistry and nano-topography scale modulated the macrophage-related osteo-immune environment by changing the expression levels of inflammatory cytokines, osteoclastic activities, and osteogenic, angiogenic, and fibrogenic factors.…”

Section: Discussionmentioning

confidence: 99%

Amorphous calcium phosphate NPs-mediated macrophage response and modulate BMSCs osteogenesis

Chen

Qiao

Liu

et al. 2020

Preprint

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Objective:To evaluate macrophage responses to ACP nanoparticles and the effect of ACP nanoparticle/macrophage-modulated environments on the osteogenic ability of BMSCs.Materials and methods:Macrophage polarization and cytokine expression were determined by SEM, cytoskeletal staining, RT-PCR and ELISA. ROS and autophagy expression were evaluated. TMT™ quantitative protein analysis was used to evaluate protein expression. BMSC osteogenic differentiation was detected by ALP staining, Alizarin Red solution staining and RT-PCR.ResultsACP nanoparticles changed macrophage morphology and polarized into M1 type. ACP nanoparticles promoted autophagy and induced the production of ROS at high concentrations. ACP nanoparticle/macrophage-modulated environments weakened the osteogenic ability of BMSCs.ConclusionACP nanoparticles polarize macrophages into the M1 phenotype. ACP nanoparticle/macrophage-modulated environments weaken the osteogenic ability of BMSCs.

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“…Such findings are of key importance demonstrating ENMs improved capability (vs. their bulk counterparts) to reach and directly interact with APCs with a potential to modulate and compromise normal and optimal cellular functions. Indeed, previous evidence has demonstrated the capacity of ENMs to modulate the function of APCs including perturbation of their polarity which is critical particularly in the context of inflammatory disease and type I allergic hypersensitivity reactions (63)(64)(65).…”

Section: Interaction With Antigen Presenting Cells (Apcs)mentioning

confidence: 99%

Engineered Nanomaterials and Type I Allergic Hypersensitivity Reactions

Alsaleh

Brown

2020

Front. Immunol.

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Type I allergic hypersensitivity disorders (atopy) including asthma, atopic dermatitis, allergic rhinitis, and food allergy are on the rise in developed and developing countries. Engineered nanomaterials (ENMs) span a large spectrum of material compositions including carbonic, metals, polymers, lipid-based, proteins, and peptides and are being utilized in a wide range of industries including healthcare and pharmaceuticals, electronics, construction, and food industry, and yet, regulations for the use of ENMs in consumer products are largely lacking. Prior evidence has demonstrated the potential of ENMs to induce and/or aggravate type I allergic hypersensitivity responses. Furthermore, previous studies have shown that ENMs could directly interact with and activate key T-helper 2 (Th2) effector cell types (such as mast cells) and the complement system, which could result in pseudoallergic (non-IgE-mediated) hypersensitivity reactions. Nevertheless, the underlying molecular mechanisms of ENM-mediated induction and/or exacerbation of type I immune responses are poorly understood. In this review, we first highlight key examples of studies that have demonstrated inherent immunomodulatory properties of ENMs in the context of type I allergic hypersensitivity reactions, and most importantly, we attempt to put together the potential molecular mechanisms that could drive ENM-mediated stimulation and/or aggravation of type I allergic hypersensitivity responses.

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The Current State of Nanoparticle-Induced Macrophage Polarization and Reprogramming Research

Cited by 167 publications

References 58 publications

Immunological and Toxicological Considerations for the Design of Liposomes

Immunological and Toxicological Considerations for the Design of Liposomes

Amorphous calcium phosphate NPs-mediated macrophage response and modulate BMSCs osteogenesis

Engineered Nanomaterials and Type I Allergic Hypersensitivity Reactions

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