The current improvement in nanoscience and nanotechnology areas has attracted researchers' attention to biofuel, bioengineering, and biomedical and mechanical engineering applications. However, there is no report on the extension of Buongiorno's model incorporating the Cattaneo-Christov theory and the generalized Fick's law to reflect the significant impacts of Brownian motion, thermophoresis diffusion, thermal radiation, and activation energy. The governing partial differential equations (PDEs) suitable to model the case as mentioned above were converted into a unified set of ordinary differential equations (ODEs) by applying appropriate similarity transformations and solved numerically by using the Spectral Local Linearization Method (SLLM) and MATLAB in-built package. The SLLM numerical method provides robustness results with a higher level of exactness and low‐computational cost. It is worthy to conclude that the nanoparticles concentration distribution can be heightened considerably either by diminishing the Prandtl number and concentration relaxation parameter or increasing the values of nanoparticles concentration Biot number and activation energy parameter. An attractive reduction in the surface drag force coefficient is achievable via the intensifying values of the non-Newtonian parameter.