Physical characteristics and in vitro skin permeation of elastic liposomes loaded with caffeic acid-hydroxypropyl-β-cyclodextrin

Im, Na Ri; Kim, Kyoung Mi; Young, Suh Ji; Park, Soo Nam

doi:10.1007/s11814-016-0146-y

Cited by 11 publications

(14 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The size of deformable liposomes containing 15 and 20% edge activator (DL3 and DL4) was increased significantly after 2 weeks, indicating low stability. Increased edge activator content in deformable liposomes decreased their stability, resulting in the destruction and aggregation of particles . Therefore, less than 10% polyglyceryl‐3‐methylglucose distearate should be used in the formulation of deformable liposomes to maintain the stability of the formulation.…”

Section: Resultsmentioning

confidence: 99%

“…The particle sizes of normal liposomes also increased after extrusion (Figure red bar) and they were unstable with heterogeneous distributions (data not shown). In general, typical liposomes are destroyed when passing through the small membrane pores and their components are recombined and aggregated . Although edge activators increase the deformability of liposomes, they also weaken the interactions between membrane lipids; thus, liposomes are easily destroyed because of an excessive amount of edge activator and physical stress, such as extrusion .…”

Section: Resultsmentioning

confidence: 99%

“…This molecule is a nonionic edge activator that contains a polyglyceryl group at the 3‐methylglucose, which increases membrane stability (Figure B). Recently, this stabilizer/surfactant has been used as an edge activator in deformable liposomes with particle sizes greater than 200 nm to improve their stability and deformability; these liposomes showed a high skin penetration rate . It has not been fully explained how this edge activator increases liposome deformability.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Preparation and Physicochemical Properties of a Cysteine Derivative‐Loaded Deformable Liposomes in Hydrogel for Enhancing Whitening Effects

Jeong

Kim

et al. 2018

Euro J Lipid Sci & Tech

Self Cite

View full text Add to dashboard Cite

Whitening materials cannot easily cross the skin barrier (stratum corneum) to reach melanocytes in the basal layer for inhibiting melanin production. This study aims to construct a novel deformable liposome using polyglyceryl‐3‐methylglucose distearate as an edge activator and a hydrogel containing hyaluronic acid (HA) and hydroxyethyl cellulose (HEC), as well as to investigate the synergistic effect of this system on the delivery of a cysteine derivative, methyl‐2‐acetylamino‐3‐(4‐hydroxyl‐3,5‐dimethoxybenzoylthio)propanoate (MP) as a whitening agent. The optimized deformable liposome (DL2) contains 10% edge activator and has a particle size of 78.2 ± 2.7 nm, a zeta potential of −29.9 ± 1.8 mV, a polydispersity index of 0.248, and an entrapment efficiency of 90.7 ± 1.7%. MP‐loaded DL2 has higher stability and deformability than DL2 without MP, as well as exerting a higher whitening effect than that observe with MP alone. In addition, MP‐loaded DL2 is incorporated into a hydrogel in a dual drug‐delivery system and the stability after hydrogel incorporation is evaluated. In Franz cells, the MP‐loaded deformable liposome‐hydrogel complex shows the highest skin permeation and penetration of MP. Practical Applications: In general, it is very difficult for whitening agents to penetrate a skin layer for reducing skin pigmentation. It is important to transfer whitening agents to the basal layer without causing physical damage to the skin. Deformable liposomes containing 10% polyglyceryl‐3‐methylglucose distearate in a hydrogel complex maximize the skin permeation of a cysteine derivative as a whitening agent. This finding indicates that the deformable liposome‐hydrogel complex is a potential delivery system for treatment of skin hyperpigmentation. The penetration mechanism of drugs in the skin by deformable liposome‐hydrogel complexes is as follows: Hydrogel hydrates stratum corneum to secure the route of drugs or nanocarrier permeation. polyglyceryl‐3‐methylglucose distearate as an edge activator enhances the fluidity of the stratum corneum lipid layer and the deformability of liposome. The edge activator‐based deformable liposomes pass through the stratum corneum stably.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Preparation and Physicochemical Properties of a Cysteine Derivative‐Loaded Deformable Liposomes in Hydrogel for Enhancing Whitening Effects

Jeong

Kim

et al. 2018

Euro J Lipid Sci & Tech

Self Cite

View full text Add to dashboard Cite

show abstract

“…The large specific surface area of nanoparticles and mesoporous/hollow nanostructures increases the amount of drug/gene loading. To exploit these advantages, many researchers have designed nanocarriers such as liposomes [ 12 , 13 , 14 , 15 ], polymeric micelles [ 16 , 17 , 18 ], polymeric nanoparticles [ 19 , 20 , 21 ], carbon nanotubes [ 22 , 23 ], reduced graphene oxides [ 24 , 25 , 26 ], gold nanoparticles [ 27 , 28 , 29 ], magnetic nanoparticles [ 30 , 31 , 32 ], and lanthanide-doped upconversion nanoparticles (UCNPs) [ 33 , 34 , 35 , 36 , 37 , 38 ].…”

Section: Introductionmentioning

confidence: 99%

Lanthanide-Doped Upconversion Nanocarriers for Drug and Gene Delivery

Lee

Park

2018

Nanomaterials

View full text Add to dashboard Cite

Compared to traditional cancer treatments, drug/gene delivery is an advanced, safe, and efficient method. Nanoparticles are widely used as nanocarriers in a drug/gene delivery system due to their long circulation time and low multi-drug resistance. In particular, lanthanide-doped upconversion nanoparticles (UCNPs) that can emit UV and visible light by near-infrared (NIR) upconversion demonstrated more efficient and safer drug/gene delivery. Because of the low penetration depth of UV and visible light, a photoinduced reaction such as photocleavage or photoisomerization has proven restrictive. However, NIR light has high tissue penetration depth and stimulates the photoinduced reaction through UV and visible emissions from lanthanide-doped UCNPs. This review discusses the optical properties of UCNPs that are useful in bioapplications and drug/gene delivery systems using the UCNPs as a photoreaction inducer.

show abstract

“…Recent reports describe the preparation of elastic nanoliposomes through the use of nonionic surfactants such as polyglyceryl-3-methylglucose distearate as an edge activator [ 17 , 18 , 19 ]. This surfactant has two alkyl chains, unlike an edge activator with a single alkyl chain that is used in conventional elastic nanoliposomes.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Alkyl Chain Number in Sucrose Surfactant on the Physical Properties of Quercetin-Loaded Deformable Nanoliposome and Its Effect on In Vitro Human Skin Penetration

Hong

Han

et al. 2018

Nanomaterials

Self Cite

View full text Add to dashboard Cite

Non-invasive skin penetration of a drug is increased by an edge activator, which enhances the nanoliposome deformability. The objective of this study was to investigate the role of the alkyl chain number of sucrose surfactants as an edge activator in elastic nanoliposomes. In addition, the physicochemical properties of the elastic nanoliposomes were characterized and an in vitro human skin permeation study was performed. Elastic nanoliposomes that were composed of sucrose monostearate (MELQ), sucrose distearate (DELQ), and sucrose tristearte (TELQ) were prepared using a thin-film hydration method. Particle size and entrapment efficiency of elastic nanoliposomes increased proportionally with an increase in the amounts and the numbers of the stearate in sucrose surfactant. Deformability of elastic nanoliposomes was indicated as DELQ > MELQ > TELQ and the same pattern was revealed through the in vitro human skin permeability tests. These results suggest that the number of alkyl chains of sucrose surfactant as edge activator affects the physicochemical property, stability, and skin permeability in elastic nanoliposome. Our findings give a valuable platform for the development of elastic nanoliposomes as skin drug delivery systems.

show abstract

Physical characteristics and in vitro skin permeation of elastic liposomes loaded with caffeic acid-hydroxypropyl-β-cyclodextrin

Cited by 11 publications

References 41 publications

Preparation and Physicochemical Properties of a Cysteine Derivative‐Loaded Deformable Liposomes in Hydrogel for Enhancing Whitening Effects

Preparation and Physicochemical Properties of a Cysteine Derivative‐Loaded Deformable Liposomes in Hydrogel for Enhancing Whitening Effects

Lanthanide-Doped Upconversion Nanocarriers for Drug and Gene Delivery

The Effect of Alkyl Chain Number in Sucrose Surfactant on the Physical Properties of Quercetin-Loaded Deformable Nanoliposome and Its Effect on In Vitro Human Skin Penetration

Contact Info

Product

Resources

About