This paper assessed some physico-chemical parameters of Cabugao Bay in Catanduanes Island, Luzon, Philippines during November-December 2017 and January 2018, by evaluating seven quality parameters. Physical parameters included temperature, conductivity, and turbidity. Chemical parameters were pH, chlorine, ammonia, and dissolved oxygen. Descriptive method of research was used through fieldwork survey. Six sampling sites were considered. Results showed that the temperature of the bay is within the standard set by the Department of Environment and Natural Resources (DENR) in 2016. Conductivity and turbidity of the water provided high values indicating human activity disturbances, presence of industries such as generators, oil storage, vulcanizing, automobile repair, and other maintenance ventures. The chemical characteristics of the bay have no severe signs. However, there are indications that some chemical substances are affected by human wastes, domestic wastes, agricultural wastes, and other natural disturbances to water quality considering that the dissolved oxygen exceeded the standards. Results imply for sustainable ecosystem-based management (EBM) by addressing fisheries activities, tourism and human activities. Future studies may include other parameters: silicate, mercury, phosphate, iron (Fe), and other metallic substances; and studies on diurnal fluctuations of turbidity and determination of total solids, total organic matter, and sediment analysis throughout the bay.