Physical disability among older Italians with diabetes. The ILSA Study

Maggi, Stefania; Noale, Marianna; Gallina, Pietro; Marzari, Chiara; Bianchi, Daniele; Limongi, Federica; Crepaldi, Gaetano

doi:10.1007/s00125-004-1555-8

Cited by 61 publications

(55 citation statements)

References 10 publications

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“…The differential impact of diabetes by sex on LED can be explained largely by the fact that women with diabetes had longer LE and significantly higher prevalence of disability, which is consistent with previously reported data for women in general [9,25].…”

Section: Discussionsupporting

confidence: 90%

Burden of diabetes in Australia: life expectancy and disability-free life expectancy in adults with diabetes

et al. 2016

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Aims/hypothesis The aim of this work was to estimate the life expectancy (LE) and disability-free life expectancy (DFLE) for adults with and without diabetes. Methods The Chiang method and the adapted Sullivan method were used to estimate LE and DFLE by age and sex. Mortality data in 2011 were available from the National Diabetes Services Scheme for diabetes and from standard national mortality datasets for the general population. Data on prevalence of disability and severe or profound core activity limitation were derived from the 2012 Australian Survey of Disability, Ageing and Carers (SDAC). The definitions of disability used in the SDAC followed the International Classification of Functioning, Disability and Health. Data on diabetes prevalence were derived from the Australian Diabetes, Obesity and Lifestyle study. ResultsThe estimated LE and DFLE (with 95% uncertainty interval [UI]) at age 50 years were 30.2 (30.0, 30.4) and 12.7 (11.5, 13.7) years, respectively, for men with diabetes, and the estimates were 33.9 (33.6, 34.1) and 13.1 (12.3, 13.9) years, respectively, for women with diabetes. The estimated loss of LE associated with diabetes at age 50 years was 3.2 (3.0, 3.4) years for men and 3.1 (2.9, 3.4) years for women, as compared with their counterparts without diabetes. The corresponding estimated loss of DFLE was 8.2 (6.7, 9.7) years for men and 9.1 (7.9, 10.4) years for women. Women with diabetes spent a greater number of absolute years and a greater proportion of their life with disability as compared with men with diabetes and women without diabetes. The gains in LE and DFLE across the whole population at age 50 years after hypothetically eliminating diagnosed diabetes were 0.6 (0.5, 0.6) years and 1.8 (1.0, 2.8) years. Conclusions/interpretation In adults, diabetes results in a modest reduction in LE and a substantial reduction in DFLE. Efforts to identify the specific causes of disability and effective interventions are needed.

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Section: Discussionsupporting

confidence: 90%

Burden of diabetes in Australia: life expectancy and disability-free life expectancy in adults with diabetes

et al. 2016

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“…Particularly interesting are the strong associations of depression and diabetes with poor physical function. In fact, even if the relationship of physical function with depression and diabetes have already been documented by previous studies [32][33][34] , it is still not so obvious as in other diseases in which physical impairment represents a common feature, such as in neurological conditions (e.g. cerebrovascular disease, dementia, Parkinson's disease) [35][36][37] or in complex multi-systems syndromes (e.g.…”

Section: Discussionmentioning

confidence: 99%

Comorbidity and Physical Function: Results from the Aging and Longevity Study in the Sirente Geographic Area (ilSIRENTE Study)

Cesari¹,

Onder²,

Russo³

et al. 2006

Gerontology

144

101

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Background: Physical function measures have gained increased importance in the evaluation of older persons. The presence of comorbidity is a major and growing issue in geriatrics. Objective: To evaluate the relationship between comorbidity and physical function in community-dwelling older persons. Methods: Data are from baseline evaluation of the ilSIRENTE study (n = 364). Physical performance was assessed using the Short Physical Performance Battery (SPPB) and the 4-meter walking test. Muscle strength was measured by hand-grip strength. Functional performance was assessed using Basic and Instrumental Activities of Daily Living (ADLs and IADLs, respectively). Comorbidity was defined as ≧3 clinical conditions. Analyses of covariance and linear regressions were performed to evaluate the relationship between comorbidity and physical function. Results: The mean age of participants was 85.9 (SD = 4.9) years. About one third (37.4%) of participants reported ≧3 clinical conditions. Participants with comorbidity had significantly worse results in all the physical function tests. Participants with comorbidity had significantly lower adjusted results for the 4-meter walking test (0.444 m/s) and the SPPB score (6.131) compared to those without comorbidity (0.531 m/s and 7.221; all p = 0.001, respectively). Participants with comorbidity were more IADL-impaired (3.152) than participants without comorbidity (2.767; p = 0.04). No significant association of ADLs and hand-grip strength with comorbidity was reported. Similar strengths of association for the 4-meter walking test (per SD increase, β = –0.280; p = 0.001) and the SPPB (per SD increase, β = –0.285; p = 0.001) with comorbidity were reported. Conclusions: Physical function measures, especially walking speed and SPPB, are associated with comorbidity. Physical performance measures may improve the clinical evaluation of older persons.

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“…Consequently, it is not surprising that multiple factors have been implicated in the development of disability in type 2 diabetic patients. Cross-sectional associations have included age (1)(2)(3), sex (1,3), obesity (1-3), insulin treatment (3), peripheral neuropathy (3), coronary heart disease (CHD) (1,3), stroke (1), peripheral arterial disease (1,2), vision loss (1), depression (2,3), and arthritis (1,2). One longitudinal study of incident disability in older diabetic women found associations with baseline functional difficulty, older age, obesity, physical inactivity, CHD, arthritis, and vision loss (5).…”

mentioning

confidence: 99%

Longitudinal Predictors of Reduced Mobility and Physical Disability in Patients With Type 2 Diabetes

Bruce

Davis²,

Davis³

2005

Diabetes Care

128

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OBJECTIVE -The purpose of this study was to determine longitudinal predictors of impaired mobility and physical disability in patients with type 2 diabetes.RESEARCH DESIGN AND METHODS -We studied patients with type 2 diabetes who participated in a prospective, community-based study. A wide range of baseline variables were examined to determine whether they predicted future difficulties with 1) mobility and 2) basic activities of daily living (ADLs) in patients free of ADLs difficulty at baseline. To study mobility impairment, subjects with baseline mobility problems were also excluded.RESULTS -After an average 4.6 Ϯ 2.3 and 4.8 Ϯ 2.3 years of follow-up in 818 and 934 patients, respectively, 28.5% of subjects had developed new mobility impairment and 18.1% had developed new ADL disability. In Cox proportional hazards models, the risk of mobility impairment was significantly increased by older age (6%/year), peripheral neuropathy (40% increase), stroke history (123%), insulin treatment (117%), albuminuria, and arthritis (82%); taking exercise and being married lowered the risk (by 39 and 32%, respectively). The risk of new ADL disability was increased by baseline mobility problems (222% increase), stroke (92%), claudication (67%), and depression (41%) and was also influenced by age, smoking, lack of exercise, nonfluency in English, and indigenous Australian ethnicity.CONCLUSIONS -Both mobility impairment and ADL disability in type 2 diabetes have multiple causes that are due to diabetes complications and common comorbidities. The specific causes of each functional problem are largely distinct, and different approaches may be required to prevent their onset or progression.

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Physical disability among older Italians with diabetes. The ILSA Study

Cited by 61 publications

References 10 publications

Burden of diabetes in Australia: life expectancy and disability-free life expectancy in adults with diabetes

Burden of diabetes in Australia: life expectancy and disability-free life expectancy in adults with diabetes

Comorbidity and Physical Function: Results from the Aging and Longevity Study in the Sirente Geographic Area (ilSIRENTE Study)

Longitudinal Predictors of Reduced Mobility and Physical Disability in Patients With Type 2 Diabetes

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