Physical exercise and quality of life in cancer patients following high dose chemotherapy and autologous bone marrow transplantation

Courneya, Kerry S.; Keats, Melanie R.; Turner, A. Robert

doi:10.1002/(sici)1099-1611(200003/04)9:2<127::aid-pon438>3.0.co;2-l

Cited by 147 publications

(95 citation statements)

References 17 publications

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“…Due to existing research, we assumed that physical exercise therapy would improve endurance, 12 strength 24 and some areas of the quality of life. 30 Regarding the secondary concerns, we assumed that a physical exercise intervention would have a positive effect on haematopoietic parameters 12,25 and lung function.…”

Section: Introductionsupporting

confidence: 81%

“…One can hypothesize that exercise therapy probably helped maintain or even improve some qualityof-life items of these patients. This outcome is supported by results observed by Courneya et al 30 These authors found that the duration of daily bike riding directly correlated with the quality of life of HSCT inpatients. Similar results indicated a positive influence of physical exercise on the level of fatigue in HSCT patients.…”

Section: Discussionmentioning

confidence: 74%

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A controlled randomized study examining the effects of exercise therapy on patients undergoing haematopoietic stem cell transplantation

Baumann

Kraut

Schüle

et al. 2009

Bone Marrow Transplant

160

188

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A haematopoietic SCT (HSCT) can cause severe side effects, which may have a profound impact on a patient's life both physically and psychologically. Some studies have shown that physical activity has positive effects for inpatients after an HSCT. Therefore, the question arises whether a controlled exercise programme right from the beginning of the conditioning phase could help contribute to a patient's physical and psychological recovery. To evaluate the different effects of specific, moderate physical activities on the physical and psychological condition of HSCT patients we performed a controlled randomized study with 64 inpatients undergoing an allogeneic or autologous HSCT. The patients were randomly assigned to two groups. Although the training group took part in a specific programme of exercise therapy twice a day throughout the entire hospitalization phase, patients in the control group were offered the hospital's standard mobilization programme. The results of this study showed significant differences in favour of the training group regarding strength, endurance, lung function and quality of life. However, further studies are needed to confirm these results.

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Section: Introductionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 74%

A controlled randomized study examining the effects of exercise therapy on patients undergoing haematopoietic stem cell transplantation

Baumann

Kraut

Schüle

et al. 2009

Bone Marrow Transplant

160

188

View full text Add to dashboard Cite

show abstract

“…These data also demonstrate that a spontaneous return to normal or even optimal functional capacity is unlikely to occur in this patient population during the sub-acute phase of recovery, adding further impetus to previous calls for implementing rehabilitation interventions for SCT patients early in the sub-acute recovery phase. 5,25 …”

supporting

confidence: 91%

“…An important secondary observation from this study is the fact that physical performance was similar regardless of how much time had transpired since transplantation (Figure 4). These findings support the suggestion by Courneya et al 25 that patients in the sub-acute phase of recovery generally have a disinterest in voluntarily engaging in exercise activities.…”

Section: Groupmentioning

confidence: 99%

Functional performance status of hematopoietic SCT recipients in the sub-acute phase of recovery

Morris

Brueilly

Scheetz

et al. 2009

Bone Marrow Transplant

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This study assessed the functional capacity of sub-acute SCT recipients using validated physical performance tests, including 6-min walk distance, repeated sit-to-stand time and 50-ft walk time, and compared these outcomes with those reported for a heterogeneous oncology population. The medical records of 80 consecutive sub-acute SCT recipients not receiving corticosteroids were retrospectively reviewed for demographic, medical and anthropometric information, and outcomes for these physical performance tests administered at the time of initial physiotherapy evaluation. Measures of central tendency, 95% confidence intervals, unpaired t-tests and correlation coefficients were calculated using a SPSS statistical package. SCT recipients completed the 50-ft walk in 10.66 ± 4.43 s, repeated sit-to-stand trial in 4.16 ± 1.82 s and walked 400.2 m in 6 min. For the timed tests, SCT recipients were approximately twice as fast as a heterogeneous group of oncology patients and walked approximately 50% further in 6 min. No overlap in the 95% confidence intervals for the two groups was observed for any of the tests. These results (1) suggest that reference values describing the functional capacity of a heterogeneous oncology population underestimate the functional capacity of SCT recipients and (2) provide clinically useful reference values for assessing functional capacity of sub-acute SCT recipients referred for physiotherapy.

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“…The physical activity levels of adult hematological cancer survivors are indeed rather low and usually below the recommended levels. [13][14][15][16][17][18][19] Low physical activity levels impact a diverse set of outcomes, including fatigue 17 (though some controversy exists 20,21 ), sleep, 20 quality of life (QOL) 16,22 and risk of cardiovascular disease and hypothyroidism. 17 In ALL survivors, low physical activity levels begin during the first two decades of life.…”

Section: Introductionmentioning

confidence: 99%

Exercise in adult and pediatric hematological cancer survivors: an intervention review

et al. 2010

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Observational research has shown that the physical activity levels of survivors of hematological cancer are low, with deleterious health consequences. This review summarizes the research on exercise interventions in adult and pediatric hematological cancer survivors. We searched MEDLINE, SPORTDiscus, CINAHL, Embase, Cochrane and PEDro through September 2009 for exercise intervention studies in children and adults with any type of hematological cancer. In the 24 adult intervention studies reviewed, we found strong evidence (that is, X3 high-quality studies and X75% reporting a significant benefit) for a benefit on body composition. Weak, but promising, evidence (X3 high-quality studies, but o75% reporting a significant benefit) was found for cardiorespiratory fitness, fatigue, muscle strength, physical functioning and quality of life. In pediatric interventions (13 studies), we found strong evidence for a benefit on muscle strength and cardiorespiratory fitness, particularly, if training was conducted in the hospital setting. Evidence is weak for ankle dorsiflexion, physical functioning and body composition. No exerciserelated risks were identified in adults or children studies. Though more randomized controlled trials are needed, a growing body of literature supports the notion that regular physical activity is safe and has potential benefits for both adult and pediatric hematological cancer survivors.

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Physical exercise and quality of life in cancer patients following high dose chemotherapy and autologous bone marrow transplantation

Cited by 147 publications

References 17 publications

A controlled randomized study examining the effects of exercise therapy on patients undergoing haematopoietic stem cell transplantation

A controlled randomized study examining the effects of exercise therapy on patients undergoing haematopoietic stem cell transplantation

Functional performance status of hematopoietic SCT recipients in the sub-acute phase of recovery

Exercise in adult and pediatric hematological cancer survivors: an intervention review

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