2017
DOI: 10.1161/strokeaha.117.017296
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Physical Exercise Improves Cognitive Outcomes in 2 Models of Transient Cerebral Ischemia

Abstract: Background and Purpose Preclinical studies suggest that exercise can enhance cognition after cerebral ischemia but often employ long training regiments and test cognition during or acutely after training. The cognitive changes may result from enhanced physical fitness and may only provide acute benefit. We sought to determine if a short period of exercise after cerebral ischemia could improve cognitive outcomes when measured days after completion of exercise training in two cerebral ischemia models. Methods … Show more

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Cited by 15 publications
(19 citation statements)
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“…Long periods of exercise training following ischemia was found to enhance the induction of learning dependent LTP in the hippocampal CA3 region [181]. Additionally, short periods of moderate treadmill exercise in two different models of CI were found to enhance cognitive function in rats as indicated by improved hippocampal-dependent contextual fear memory [182]. Interestingly, exercise has also been shown to enhance short term plasticity, as indicated by increased PPF, as well as upregulate innervation from regions within the brain that are important for spatial memory and theta rhythm generation [183].…”
Section: Combatting Disrupted Plasticity Mechanisms: Treatments/theramentioning
confidence: 99%
“…Long periods of exercise training following ischemia was found to enhance the induction of learning dependent LTP in the hippocampal CA3 region [181]. Additionally, short periods of moderate treadmill exercise in two different models of CI were found to enhance cognitive function in rats as indicated by improved hippocampal-dependent contextual fear memory [182]. Interestingly, exercise has also been shown to enhance short term plasticity, as indicated by increased PPF, as well as upregulate innervation from regions within the brain that are important for spatial memory and theta rhythm generation [183].…”
Section: Combatting Disrupted Plasticity Mechanisms: Treatments/theramentioning
confidence: 99%
“…In contrast, significant atrophy of the medial temporal lobe was found in the control group. This area with the increase in regional blood flow after exercise might be associated with cognition, indicating that exercise was a possible means of ameliorating atrophy post-stroke and improving long-term cognition [16,37,38].…”
Section: Discussionmentioning
confidence: 99%
“…Three days prior to undergoing MCAO surgery, rats were exposed to the treadmill for a 3 day period, in order to acclimate themselves and reduce stress in later behavioral experiments. Three days following MCAO animals began daily exercise training for 6 days (Stradecki-Cohan et al, 2017). All animals were placed on the treadmill for a 2 min warm up at a speed of 5 m/min.…”
Section: Methodsmentioning
confidence: 99%
“…The exercise speeds for each group were as follows; no exercise (0 m/min), mild exercise (6 m/min), moderate exercise (9 m/min), and intense exercise (12 m/min). In our previous study, 3 month old male rats were able to run at a speed of 18 m/min for 30 min (Stradecki-Cohan et al, 2017). However, 12 month old rats were unable to run at this speed after MCAO.…”
Section: Methodsmentioning
confidence: 99%
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