Physical exercise training for cystic fibrosis

Radtke, Thomas; Nolan, Sarah J; Hebestreit, Helge; Kriemler, Susi

doi:10.1002/14651858.cd002768.pub4

Cited by 121 publications

(103 citation statements)

References 83 publications

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“…Nixon et al administered the Kriska's Modifiable Activity Questionnaire (MAQ) to 30 CF patients and 30 healthy controls aged 7–17 years to assess physical activity over the previous year. While mean total hours of physical activity per week and the relative intensity of physical activity expressed as MET‐h · week were similar in both groups, the time per week spent in vigorous activities was significantly lower in the CF patients . Using questions from the Centers for Disease Control's Youth Risk Behavior Survey (YRBS), Britto et al found no differences between CF patients aged 12–19 years and their matched peers in the participation in the following three types of activities: team sports, physical education classes, and the number of activities per week that “make you sweat or breathe hard.” Younger CF adolescents were more likely to participate in all three types activities when adjusted for gender and health status.…”

Section: Discussionmentioning

confidence: 99%

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Perspective on cystic fibrosis and physical activity: Is there a difference compared to healthy individuals?

Jantzen

Opoku-Pare

Bieli

et al. 2016

Pediatric Pulmonology

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While we found similar levels of physical activity measured by accelerometry in patients with CF compared to healthy controls in general, young school-aged children showed less engagement in strenuous activities than their healthy counterparts. As the reduced physical activity in young school children was not likely to be explained by the disease state, strenuous physical activity may be enhanced by advocating exercise and sport. Pediatr Pulmonol. 2016;51:1020-1030. © 2016 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

“…Exercise and habitual physical activity (HPA) are important components in the care of patients with cystic fibrosis (CF) . A high level of physical activity may lead to improved airway clearance by increasing trans‐epithelial fluid transport, vibration, and raised ventilation and may reduce or even prevent lung function decline …”

Section: Introductionmentioning

confidence: 99%

Perspective on cystic fibrosis and physical activity: Is there a difference compared to healthy individuals?

Jantzen

Opoku-Pare

Bieli

et al. 2016

Pediatric Pulmonology

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“…Strategies to combine effective interventions to minimise treatment time are needed. Exercise improves physical fitness and may also improve lung function and quality of life in people with CF [5]. If exercise also aids mucus clearance, it would reduce treatment time, as exercise could substitute airway clearance interventions, while gaining the other known benefits of exercise.…”

Section: Introductionmentioning

confidence: 99%

Effects of treadmill exercise versus Flutter® on respiratory flow and sputum properties in adults with cystic fibrosis: a randomised, controlled, cross-over trial

et al. 2017

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BackgroundTreadmill exercise and airway clearance with the Flutter® device have previously been shown to improve mucus clearance mechanisms in people with cystic fibrosis (CF) but have not been compared. It is therefore not known if treadmill exercise is an adequate form of airway clearance that could replace established airway clearance techniques, such as the Flutter®. The aim of this study was to evaluate respiratory flow, sputum properties and subjective responses of treadmill exercise and Flutter® therapy, compared to resting breathing (control).MethodsTwenty-four adults with mild to severe CF lung disease (FEV1 28–86% predicted) completed a three-day randomised, controlled, cross-over study. Interventions consisted of 20 min of resting breathing (control), treadmill exercise at 60% of the participant’s peak oxygen consumption and Flutter® therapy. Respiratory flow was measured during the interventions. Sputum properties (solids content and mechanical impedance) and subjective responses (ease of expectoration and sense of chest congestion) were measured before, immediately after the interventions and after 20 min of recovery.ResultsTreadmill exercise and Flutter® resulted in similar significant increases in peak expiratory flow, but only Flutter® created an expiratory airflow bias (i.e. peak expiratory flow was at least 10% higher than peak inspiratory flow). Treadmill exercise and Flutter® therapy resulted in similar significant reductions in sputum mechanical impedance, but only treadmill exercise caused a transient increase in sputum hydration. Treadmill exercise improved ease of expectoration and Flutter® therapy improved subjective sense of chest congestion.ConclusionsA single bout of treadmill exercise and Flutter® therapy were equally effective in augmenting mucus clearance mechanisms in adults with CF. Only longer term studies, however, will determine if exercise alone is an adequate form of airway clearance therapy that could replace other airway clearance techniques.Trial registrationAustralian and New Zealand Clinical Trials Registry, Registration number #ACTRN12609000168257, Retrospectively registered (Date submitted to registry 26/2/2009, First participant enrolled 27/2/2009, Date registered 6/4/2009).Electronic supplementary materialThe online version of this article (doi:10.1186/s12890-016-0360-8) contains supplementary material, which is available to authorized users.

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“…The life expectancy of people with cystic fibrosis (CF) has increased dramatically over the last three decades with a growing armamentarium of pharmacologic and non‐pharmacologic interventions that positively impact health outcomes. Exercise training is one non‐pharmacologic intervention that is a recommended adjunctive form of airway clearance and has been shown to have many promising health outcomes including improved exercise capacity (EC), improved or reduced rate of decline in lung function, and improved quality of life in children and adolescents with CF. Regular exercise training can increase EC and many studies have demonstrated that higher EC is associated with favorable health outcomes such as greater life expectancy, decreased inflammation (IgG levels), increased bone mineral density, reduced hospitalizations due to pulmonary exacerbation, and improved quality of life in children and adolescents with CF.…”

Section: Introductionmentioning

confidence: 99%

Relationship between exercise capacity and glucose tolerance in cystic fibrosis

Foster

Huang

Zhang

et al. 2017

Pediatric Pulmonology

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These data provide evidence that poor glucose tolerance is associated with lower EC in pediatric patients with CF. There was a significant relationship between glucose and insulin values obtained by OGTT with EC in a sample of non-diabetic patients with preserved lung function. Future studies are warranted to confirm these findings and investigate the potential role of exercise in the management or prevention of CFRD.

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Physical exercise training for cystic fibrosis

Abstract: Analysis 1.1. Comparison 1 Aerobic training versus no physical training, Outcome 1 Change in VO2 peak during maximal exercise (ml/min per kg BW

Cited by 121 publications

References 83 publications

Perspective on cystic fibrosis and physical activity: Is there a difference compared to healthy individuals?

Perspective on cystic fibrosis and physical activity: Is there a difference compared to healthy individuals?

Effects of treadmill exercise versus Flutter® on respiratory flow and sputum properties in adults with cystic fibrosis: a randomised, controlled, cross-over trial

Relationship between exercise capacity and glucose tolerance in cystic fibrosis

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