Physical gels of telechelic triblock copolymers with precisely defined junction multiplicity

Skrzeszewska, Paulina J.; Wolf, Frits A. de; Werten, Marc W. T.; Moers, Antoine P. H. A.; Stuart, Martien A. Cohen; Gucht, Jasper van der

doi:10.1039/b819967a

Cited by 59 publications

(130 citation statements)

References 26 publications

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“…A promising class of responsive materials is that of physically cross-linked polymer networks. These transient networks are typically assembled from telechelic polymers [1][2][3][4][5] or linear triblock copolymers, [6][7][8][9] although other architectures have been investigated as well. [10][11][12][13][14] Most widely studied are ABA triblock copolymers with hydrophobic end groups and a hydrophilic middle block.…”

mentioning

confidence: 99%

Multiresponsive Reversible Gels Based on Charge‐Driven Assembly

et al. 2010

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Vernetzt: Ein ABA‐Triblock‐Copolymer mit geladenen Endgruppen und ein entgegengesetzt geladener Polyelektrolyt bilden Gele, die auf Änderungen in Konzentration, Temperatur, Ionenstärke, pH‐Wert und Ladungszusammensetzung reagieren. Oberhalb der kritischen Gelbildungskonzentration verbrücken die Triblock‐Copolymere Micellen zu einem probendurchspannenden transienten Netzwerk aus verknüpften Micellen.

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confidence: 99%

Multiresponsive Reversible Gels Based on Charge‐Driven Assembly

et al. 2010

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“…38 Trimeric coiled-coils based on collagen 52,62 and fibrin-inspired 63 triple helices have been used as crosslinking domains, and the linear mechanical behavior of these gels agrees well with the established models [34][35][36] for physical gels. 52 Changing the coiled-coil from tetrameric to pentameric results in an increase in the hydrogel modulus and a slowing of the gel erosion rate, corresponding to an increase in the fraction of elastically effective chains within the network. 39 It is hypothesized that this effect is observed because tetrameric coiled-coils can form junctions with an integer number of loops.…”

Section: Physical Gels With Protein-associating Domainsmentioning

confidence: 64%

“…2). 39,52 A plateau in the elastic modulus, G 0 , is observed at high frequencies, with a peak in the loss modulus, G 00 , and a crossover in G 0 and G 00 observed upon decreasing frequency. At low frequencies, terminal behavior with G 0 ¼ x 1.8 and G 00 ¼ x 0.9 is observed, close to ideal terminal relaxation behavior.…”

Section: Physical Gels With Protein-associating Domainsmentioning

confidence: 91%

Physics of engineered protein hydrogels

Kim

Tang

Olsen

2013

J Polym Sci B Polym Phys

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Artificially engineered proteins and synthetic polypeptides have attracted widespread interest as building blocks for polymer hydrogels. The biophysical properties of the proteins, such as molecular recognition abilities, folded chain structures, and sequence-dependent thermodynamic behavior, enable advances in functional, responsive, and tunable gels. This review discusses the design of polymer hydrogels that incorporate protein domains, highlighting new challenges in polymer physics that are presented by this emerging class of materials. Five types of engineered protein hydrogels are discussed: (a) physically associating protein polymer gels, (b) amorphous artificially engineered protein networks, (c) engineered proteins with crystalline domains, (d) stretchable protein tertiary structures in gels, and (e) protein gels with biological recognition properties. The physics of the protein component and the physical properties of the resulting hydrogels are summarized, illustrating how advances in understanding these systems are leading to exciting novel biofunctional hydrogels.

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“…First, compact molecular structures (triple-helices in the present case) nucleate within the sol, which, secondly, aggregate into fiber structures [15,17], thus suggesting a qualitative resemblance to colloidal gelation [3,18,19] and colloidal crystallization [20,21]. Our results should be applicable to a broad class of polymer gels where the formation of the network proceeds via connection of compact molecular structures that must first nucleate, e.g., helices in agarose, carrageenans, and gellan gum; crystallites in poly(vinyl chloride) gels; and block domains in triblock copolymers [2,22].…”

Section: Resultsmentioning

confidence: 99%

Nucleation and growth of thermoreversible polymer gels

2013

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We study the spatiotemporal low-frequency microrheology of a gelatin gel during the sol-gel transition after a fast temperature quench by tracking the motion of embedded colloidal particles. From the particle dynamics two different mechanisms responsible for the gelation of the sol phase can be identified: a fast process associated to the local nucleation of triple helices and a slow fiber growth triggered by presence of an intact network. We associate the latter to a gelation front propagating into the sol phase whose speed depends linearly on the quench depth and which accelerates the local rate of the sol-gel transition.

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Physical gels of telechelic triblock copolymers with precisely defined junction multiplicity

Cited by 59 publications

References 26 publications

Multiresponsive Reversible Gels Based on Charge‐Driven Assembly

Multiresponsive Reversible Gels Based on Charge‐Driven Assembly

Physics of engineered protein hydrogels

Nucleation and growth of thermoreversible polymer gels

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