Physical growth delays and stress dysregulation in stunted and non-stunted Ukrainian institution-reared children

Dobrova‐Krol, Natasha A.; IJzendoorn, Marinus H. van; Bakermans‐Kranenburg, Marian J.; Cyr, Chantal; Juffer, Femmie

doi:10.1016/j.infbeh.2008.04.001

Cited by 122 publications

(72 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The ELA children with larger hippocampal volumes had typical waking cortisol but elevated cortisol values throughout the day. Elevated evening cortisol values have been observed in temporarily stunted postinstitutionalized children who caught up with their physical development after placement in a family, in comparison with family-reared or chronically stunted postinstitutionalized children [55], and also in healthy children who experienced recent increases in parent-child conflict [56]. We did not assess recent parent-child conflict and this subgroup sample is small.…”

Section: Discussionmentioning

confidence: 99%

Effects of Early-Life Adversity on Hippocampal Structures and Associated HPA Axis Functions

Dahmen¹,

Puetz

Scharke

et al. 2017

Dev Neurosci

View full text Add to dashboard Cite

Early-life adversity (ELA) is one of the major risk factors for serious mental and physical health risks later in life. ELA has been associated with dysfunctional neurodevelopment, especially in brain structures such as the hippocampus, and with dysfunction of the stress system, including the hypothalamic-pituitary-adrenal (HPA) axis. Children who have experienced ELA are also more likely to suffer from mental health disorders such as depression later in life. The exact interplay of aberrant neurodevelopment and HPA axis dysfunction as risks for psychopathology is not yet clear. We investigated volume differences in the bilateral hippocampus and in stress-sensitive hippocampal subfields, behavior problems, and diurnal cortisol activity in 24 children who had experienced documented ELA (including out-of-home placement) in a circumscribed duration of adversity only in their first 3 years of life in comparison to data on 25 control children raised by their biological parents. Hippocampal volumes and stress-sensitive hippocampal subfields (Cornu ammonis [CA]1, CA3, and the granule-cell layer of the dentate gyrus [GCL-DG]) were significantly smaller in children who had experienced ELA, taking psychiatric diagnoses and dimensional psychopathological symptoms into account. ELA moderated the relationship between left hippocampal volume and cortisol: in the control group, hippocampal volumes were not related to diurnal cortisol, while in ELA children, a positive linear relationship between left hippocampal volume and diurnal cortisol was present. Our findings show that ELA is associated with altered development of the hippocampus, and an altered relationship between hippocampal volume and HPA axis activity in youth in care, even after they have lived in stable and caring foster family environments for years. Altered hippocampal development after ELA could thus be associated with a risk phenotype for the development of psychiatric disorders later in life.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of Early-Life Adversity on Hippocampal Structures and Associated HPA Axis Functions

Dahmen¹,

Puetz

Scharke

et al. 2017

Dev Neurosci

View full text Add to dashboard Cite

show abstract

“…The mean weight for the sample was 40.45 kg with a standard deviation of 11.21kg and median of 39kg. The mean BMI of the study population was observed to be 18 Malawi where children who had been admitted to an orphanage for more than one year were less malnourished than those who had been admitted for a shorter duration. In contrast to this, a study by Mwaniki EW and Makokha AN 19 found the length of stay to correlate directly with the prevalence of malnutrition.…”

Section: Discussionmentioning

confidence: 95%

“…How good or how bad an orphanage is depends on the particular country's outlook on abandoned children and obviously the financial situation of these countries 15 . Children raised in large-scale orphanages often have pervasive growth problems, including stunting (severe growth delay), and impairments in fine and gross motor skills and coordination 16,17,18 . There is limited available literature regarding nutritional problems among children residing in orphanages in India in general and in Kashmir in particular.…”

Section: Introductionmentioning

confidence: 99%

Nutritional Profile of Children in Orphanages of Kashmir Valley: A Cross sectional Study

Dar¹

2017

jmscr

View full text Add to dashboard Cite

“…[12][13][14] In a Ukraine-based study, non-stunted institutionally-reared children were found to have a significantly higher total daily cortisol production than both chronically stunted institutionreared children and family-reared children. [15] …”

Section: Anthropometrymentioning

confidence: 99%

Health and demographic profile of boys in a metropolitan reformatory home in Western India

Malgaonkar¹,

Malgaonkar²,

Kartikeyan³

2017

IOSR JDMS

View full text Add to dashboard Cite

Physical growth delays and stress dysregulation in stunted and non-stunted Ukrainian institution-reared children

Cited by 122 publications

References 54 publications

Effects of Early-Life Adversity on Hippocampal Structures and Associated HPA Axis Functions

Effects of Early-Life Adversity on Hippocampal Structures and Associated HPA Axis Functions

Nutritional Profile of Children in Orphanages of Kashmir Valley: A Cross sectional Study

Health and demographic profile of boys in a metropolitan reformatory home in Western India

Contact Info

Product

Resources

About