Physical inactivity and sedentary behavior: Overlooked risk factors in autoimmune rheumatic diseases?

Pinto, André Luíz de Carvalho Braule; Roschel, Hamilton; Pinto, Ana Lúcia de Sá; Lima, Fernanda Rodrigues; Pereira, Rosa Maria Rodrigues; Silva, Clóvis A.; Bonfá, Eloísa; Gualano, Bruno

doi:10.1016/j.autrev.2017.05.001

Cited by 86 publications

(79 citation statements)

References 136 publications

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“…In the past, bed rest was extensively used as part of the treatment for rheumatic diseases such as rheumatoid arthritis and myositis to avoid disease exacerbation and/or joint destruction. However, compelling evidence shows that disuse actually leads to joint destruction, muscle weakness and atrophy, causing reduced physical function 2,3 . Such evidence has led to the contemporary abrogation of the 'bed rest paradigm' for rheumatic diseases and has guided new approaches to clinical practice that emphasize physical activity as an important part of therapy to improve patients' symptoms 7 .…”

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confidence: 99%

Combating physical inactivity during the COVID-19 pandemic

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Combating physical inactivity during the COVID-19 pandemic

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“…Mild exercises can also help these patients. Most of the studies cited, however, advocate on even increasing intensities for those who demonstrate adaptation to the stimulus offered [22].…”

Section: Discussionmentioning

confidence: 99%

Physical Exercise Improves Quality of Life in Patients with Connective Tissue Disease

Nahas¹,

Santos²,

Alabarse³

2020

Connective Tissue Disease - Current State of the Art

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Connective tissue diseases (CTDs) affect the parts of the body that connect the structures of the body components together. As the conditions involve inflammatory responses in the joints, tendons, ligaments, skin, cornea, cartilage, bones, muscles and blood vessels, which cause symptoms of rheumatism, the CTDs can also be referred to as rheumatic diseases. The symptoms include pain, swelling, redness, warmth in a joint or affected area and functional loss of motion. The medical domain for these types of disorders is called rheumatology. Among various conditions fell under the broad heading of rheumatism, the common rheumatic disorders that here we take care of are rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), scleroderma (S), systemic sclerosis (SS), polymyositis/dermatomyositis (PM/DM), spondyloarthropathies (SA) (ankylosing spondylitis (AS) and psoriatic arthritis (PsA)), juvenile idiopathic arthritis (JIA), polymyalgia rheumatica (PMR), Sjogren's syndrome, osteoarthritis, etc. When the diagnosis of CTDs is made by the rheumatologists, they oversee a treatment plan for the patients, which may include not only medications but also physical exercises. In this chapter, we will describe how the physical exercise contributes to the patients who suffered from CTDs. Furthermore, we intend to explain what type of exercise should be performed as well as its intensity, duration frequency and the benefits of those exercises to the health of those patients.

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“…In this scenario, patients with autoimmune rheumatic diseases show marked sedentary behavior and physical inactivity, risk factors which seem to be frequently overlooked in these patients. 24 This behavior, in turn, can lead to an increase in BMI and waist circumference, which further contributes to increased insulin resistance. 25 However, in the present study, we do not measure physical activity levels in the patients with DM, or if this outcome correlates with IR in these patients.…”

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confidence: 99%

Insulin resistance is increased in adult patients with dermatomyositis

Oliveira¹,

Guimarães²,

Shinjo³

2018

Medical Express

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OBJECTIVE: To evaluate insulinemia in glucocorticoid naïve patients with dermatomyositis and to evaluate insulin resistance using the homeostatic model assessment of insulin resistance (HOMA2-IR). METHODS: This cross-sectional study included 25 dermatomyositis, non-diabetic glucocorticoid naïve patients. The control group consisted of 50 volunteers matched for age, gender, ethnicity, weight and height. The HOMA2-IR index was calculated from baseline insulin and glucose data. The International Myositis Assessment & Clinical Studies Group (IMACS) parameters were used to evaluate disease status. RESULTS: Mean age of the patients was 43.5 years and these were predominantly females. Patients had low disease activity according to IMACS parameters. Higher body mass index and waist circumference were observed in the dermatomyositis group compared to the control group. Insulin level and HOMA2-IR were also higher in patients with dermatomyositis. Moreover, analyzing dermatomyositis alone, the HOMA2-IR index correlated positively with weight, body mass index and waist circumference and was independent on disease status parameters. CONCLUSIONS: Patients with dermatomyositis had higher values for basal insulinemia, insulin resistance, body mass index and waist circumference. Moreover, HOMA2-IR moderately correlated with these anthropometric parameters. These metabolic abnormalities are related to the development of metabolic syndrome, one of the main comorbidities observed in dermatomyositis.

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Physical inactivity and sedentary behavior: Overlooked risk factors in autoimmune rheumatic diseases?

Cited by 86 publications

References 136 publications

Combating physical inactivity during the COVID-19 pandemic

Combating physical inactivity during the COVID-19 pandemic

Physical Exercise Improves Quality of Life in Patients with Connective Tissue Disease

Insulin resistance is increased in adult patients with dermatomyositis

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