Physical, Mental, and Cognitive Function in a Convenience Sample of Centenarians in Australia

Richmond, Robyn; Law, Jenaleen; Kay‐Lambkin, Frances

doi:10.1111/j.1532-5415.2011.03404.x

Cited by 49 publications

(64 citation statements)

References 21 publications

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“…32 Reliability has been shown in a range of settings, and there is evidence that it is a suitable measure of anxiety and depression in populations of older adults with or without cognitive impairment or dementia. [33][34][35] Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE). 36,37 The IQCODE was designed to measure the severity of cognitive and functional decline of participants with AD according to the subjective view of the informant.…”

Section: Explanatory Variablesmentioning

confidence: 99%

Determining the Predictors of Change in Quality of Life Self-ratings and Carer-ratings for Community-dwelling People With Alzheimer Disease

Bosboom

Alfonso

Almeida

2013

Alzheimer Disease &Amp; Associated Disorders

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The aim of this study was to determine the factors that mediate changes in Health Related Quality of Life (HRQoL) ratings by community-dwelling people with Alzheimer disease (AD) and carers over a period of 18 months. We completed an 18-month longitudinal study of 80 community-dwelling older adults diagnosed with probable AD of mild or moderate severity (NINCDS-ADRD criteria) and their family carers. The primary outcome of interest was the 18-month change in HRQoL ratings as measured with the Quality of Life-AD (QoL-AD) (by carer and by self). Explanatory variables included demographics, lifestyle, cognition, awareness, psychopathology, burden-of-care, use of medication, and functionality in daily life. We found a significant decline (8.7%, P=0.003) in QoL-AD carer-ratings, but not in self-ratings. The final parsimonious model of predictors of changes in QoL-AD self-ratings explained 22.6% of the variance; only changes on Hospital Anxiety and Depression Scale Anxiety retained significance. The final model of predictors of changes in carer-ratings explained 55.0% of the variance: that is, changes on Informant Questionnaire on Cognitive Decline in the Elderly, changes on Hospital Anxiety and Depression Scale Depression, practicing hobbies at 18 months, and number of visit(s) or admission(s) to hospital. HRQoL self-ratings and carer-ratings of community-dwelling people with AD do not decline at same rate over 18 months and changes are associated with different factors. Interventions designed to optimize quality of life of people with AD should consider carefully whose HRQoL ratings they wish to change.

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Section: Explanatory Variablesmentioning

confidence: 99%

Determining the Predictors of Change in Quality of Life Self-ratings and Carer-ratings for Community-dwelling People With Alzheimer Disease

Bosboom

Alfonso

Almeida

2013

Alzheimer Disease &Amp; Associated Disorders

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“…Functional status has been demonstrated to be related to cognition, but, again, findings appear mixed. In persons with a moderate to severe decline in functional status, specifically in ADLs, there was no relationship between functional and cognitive status (Richmond et al, 2011). Some studies have demonstrated relationships between impaired cognition (i.e., memory and mental status) and poor functioning in ADLs and IADLs among individuals with dementia, including AD (McGuire et al, 2006;Sabbagh et al, 2007).…”

Section: Functional Status As a Predictormentioning

confidence: 99%

The relationship between functional status and judgment/problem solving among individuals with dementia

Mayo

Wallhagen

Cooper

et al. 2012

Int J Geriat Psychiatry

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Objective To determine the relationship between functional status (independent activities of daily living) and judgment/problem solving and the extent to which select demographic characteristics such as dementia subtype and cognitive measures may moderate that relationship in older adult individuals with dementia. Methods The National Alzheimer’s Coordinating Center Universal Data Set was accessed for a study sample of 3,855 individuals diagnosed with dementia. Primary variables included functional status, judgment/problem solving, and cognition. Results Functional status was related to judgment/problem solving (r= 0.66; p< .0005). Functional status and cognition jointly predicted 56% of the variance in judgment/problem solving (R-squared = .56, p <.0005). As cognition decreases, the prediction of poorer judgment/problem solving by functional status became stronger. Conclusions Among individuals with a diagnosis of dementia, declining functional status as well as declining cognition should raise concerns about judgment/problem solving.

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“…Knowledge about the state of health and function of the oldest old is limited,129 with research on their drug use being scarce, and often based on small and selected samples without comparison with other age groups 130131 We know that older patients in general are underrepresented in clinical trials, so that disease-specific guideline recommendations based on evidence may not apply to older cohorts 34.…”

Section: Discussionmentioning

confidence: 99%

Validation of prescribing appropriateness criteria for older Australians using the RAND/UCLA appropriateness method

2012

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ObjectiveTo further develop and validate previously published national prescribing appropriateness criteria to assist in identifying drug-related problems (DRPs) for commonly occurring medications and medical conditions in older (≥65 years old) Australians.DesignRAND/UCLA appropriateness method.ParticipantsA panel of medication management experts were identified consisting of geriatricians/pharmacologists, clinical pharmacists and disease management advisors to organisations that produce Australian evidence-based therapeutic publications. This resulted in a round-one panel of 15 members, and a round-two panel of 12 members.Main outcome measureAgreement on all criteria.ResultsForty-eight prescribing criteria were rated. In the first rating round via email, there was disagreement regarding 17 of the criteria according to median panel ratings. During a face-to-face second round meeting, discussion resulted in retention of 25 criteria after amendments, agreement for 14 criteria with no changes required and deletion of 9 criteria. Two new criteria were added, resulting in a final validated list of 41 prescribing appropriateness criteria. Agreement after round two was reached for all 41 criteria, measured by median panel ratings and the amount of dispersion of panel ratings, based on the interpercentile range.ConclusionsA set of 41 Australian prescribing appropriateness criteria were validated by an expert panel. Use of these criteria, together with clinical judgement and other medication review processes such as patient interview, is intended to assist in improving patient care by efficiently detecting potential DRPs related to commonly occurring medicines and medical conditions in older Australians. These criteria may also contribute to the medication management education of healthcare professionals.

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Physical, Mental, and Cognitive Function in a Convenience Sample of Centenarians in Australia

Cited by 49 publications

References 21 publications

Determining the Predictors of Change in Quality of Life Self-ratings and Carer-ratings for Community-dwelling People With Alzheimer Disease

Determining the Predictors of Change in Quality of Life Self-ratings and Carer-ratings for Community-dwelling People With Alzheimer Disease

The relationship between functional status and judgment/problem solving among individuals with dementia

Validation of prescribing appropriateness criteria for older Australians using the RAND/UCLA appropriateness method

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