Physical, motor, sensory and developmental features associated with agenesis of the corpus callosum

Moes, Paul; Schilmoeller, Kathryn J.; Schilmoeller, Gary L.

doi:10.1111/j.1365-2214.2009.00942.x

Cited by 47 publications

(40 citation statements)

References 42 publications

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“…As hypothesized, proportionately more participants with AgCC than the normative sample endorsed low registration of sensory experience in both levels of analysis—Atypically High (> 1 SD) and Definitely High (> 2 SD). These results are consistent with previous research in which individuals with AgCC were reported to have high pain tolerance (Doherty et al, 2006; Moes et al, 2009), or “low registration” for pain sensation. Current results suggest that this high tolerance for pain may be related to a higher threshold for detection of pain or slower response to painful input.…”

Section: Discussionsupporting

confidence: 92%

Individuals with agenesis of the corpus callosum show sensory processing differences as measured by the sensory profile.

Demopoulos¹,

Arroyo²,

Dunn³

et al. 2015

Neuropsychology

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Objective Given reports of high pain thresholds and reduced auditory response in individuals with Agenesis of the Corpus Callosum (AgCC), this study investigated whether affected participants report atypical experiences and behaviors on a well-established sensory processing measure. Methods Fourteen participants with AgCC (ages 11-59) completed the Adolescent/Adult Sensory Profile (Brown & Dunn, 2001). Sensory profile scales were classified as “Atypical” if they were more than one standard deviation from the mean. Results Fifty-seven percent of participants with AgCC reported reduced sensory registration as compared to an expected 16% of the normative sample. Similarly, 50% of the AgCC participants reported atypically increased auditory processing difficulties. Conclusions Using a well-established sensory processing questionnaire, participants with AgCC reported measurable differences in multiple aspects of sensory processing. The most notable difference was in the quadrant of low sensory registration, suggesting that individuals with AgCC may require sensory information to be presented more slowly or at a higher intensity for adequate processing. The sensory modality that was most affected was the auditory system, which is consistent with increased rates of language disorders and Autism Spectrum Disorders in this population. Understanding sensory processing in individuals with AgCC can both elucidate the role of inter-hemispheric transfer in the development of intact sensory processing as well as contribute to our knowledge of the role of the corpus callosum in a range of disorders in which sensory processes are impacted.

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Section: Discussionsupporting

confidence: 92%

Individuals with agenesis of the corpus callosum show sensory processing differences as measured by the sensory profile.

Demopoulos¹,

Arroyo²,

Dunn³

et al. 2015

Neuropsychology

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show abstract

“…Six cases were nonspecific; of which Three had isolated ventriculomegaly and the other Three had delayed myelination. Moes et al, [13] also observed similar incidence of Degenerative/ Metabolic Diseases causing developmental delay.…”

Section: Discussionmentioning

confidence: 63%

Magnetic Resonance Imaging (MRI) Evaluation of Developmental Delay in Pediatric Patients

Ali

Syed

Murthy

et al. 2015

JCDR

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“…In light of the functional specialization of the insula, diminished connectivity in the anterior insula from the ICA analysis may indicate that AgCC has a significant effect on the anterior insular network, including the anterior cingulate cortex, middle/inferior frontal cortex, temporoparietal network, and their related functions, that is, emotional salience and attentional control. Individuals with AgCC are known to have diminished pain sensitivity and altered emotional processing (Moes et al, 2009). This corresponds with the insula's prominent role as a center of the ''pain network,'' particularly as a convergence zone for the affective and sensory components of pain (Augustine 1996;Vanhaudenhuyse et al, 2009).…”

Section: Functional Specialization Of the Insulamentioning

confidence: 99%

Resting-State Networks and the Functional Connectome of the Human Brain in Agenesis of the Corpus Callosum

Owen

Yang

et al. 2013

Brain Connectivity

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The corpus callosum is the largest white matter fiber bundle connecting the two cerebral hemispheres. In this work, we investigate the effect of callosal dysgenesis on functional magnetic resonance imaging (fMRI) restingstate networks and the functional connectome. Since alternate commissural routes between the cerebral hemispheres exist, we hypothesize that bilateral cortical networks can still be maintained in partial or even complete agenesis of the corpus callosum (AgCC). However, since these commissural routes are frequently indirect, requiring polysynaptic pathways, we hypothesize that quantitative measurements of interhemispheric functional connectivity in bilateral networks will be reduced in AgCC compared with matched controls, especially in the most highly interconnected cortical regions that are the hubs of the connectome. Seventeen resting-state networks were extracted from fMRI of 11 subjects with partial or complete AgCC and 11 matched controls. The results show that the qualitative organization of resting-state networks is very similar between controls and AgCC. However, interhemispheric functional connectivity of precuneus, posterior cingulate cortex, and insular-opercular regions was significantly reduced in AgCC. The preserved network organization was confirmed with a connectomic analysis of the resting-state fMRI data, showing five functional modules that are largely consistent across the control and AgCC groups. Hence, the reduction or even complete absence of callosal connectivity does not affect the qualitative organization of bilateral resting-state networks or the modular organization of the functional connectome, although quantitatively reduced functional connectivity can be demonstrated by measurements within bilateral cortical hubs, supporting the hypothesis that indirect polysynaptic pathways are utilized to preserve interhemispheric temporal synchrony.

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Physical, motor, sensory and developmental features associated with agenesis of the corpus callosum

Cited by 47 publications

References 42 publications

Individuals with agenesis of the corpus callosum show sensory processing differences as measured by the sensory profile.

Individuals with agenesis of the corpus callosum show sensory processing differences as measured by the sensory profile.

Magnetic Resonance Imaging (MRI) Evaluation of Developmental Delay in Pediatric Patients

Resting-State Networks and the Functional Connectome of the Human Brain in Agenesis of the Corpus Callosum

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