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The high prevalence of end-stage kidney diseases demands new treatment strategies. Decellularization approach may provide a viable option grow organs using a regenerative medicine approach. Goat kidney was decellularized by perfusion decellularization using detergents to produce an cellular construct for kidney scaffold. After pre-treatment with anticoagulant, the decellularized scaffold was analyzed for its intact three-dimensional natural architecture and vasculature. Perfusion of decellularized kidney preserved the structure and composition of renal extra-cellular matrix and vascular structures within the scaffold. No evidence of residual cellular components was found. This approach provides a model for understanding of whole organ regeneration.

Background: Intracranial tumors can arise from various locations in the brain parenchyma. Computed tomography scan (CT) and magnetic resonance imaging (MRI) are important modalities for diagnosis of intracranial tumors. The aim of the study is to study the usefulness of CT scan and MRI for the detection and evaluation of brain tumors. Subjects and Methods: This was a prospective cross sectional study comprising of 95 patients diagnosed with brain tumors clinically. CT scan was done in all the patients and MRI was done in 45 patients. Findings were correlated with histopathology. Results: In the present study, age group distribution included from 20 years to more than 50 years.In the present study males were predominant and the male to female ratio was 1.3:1. All the cases, (100%) presented with seizures, followed by headache, hemiparesis and vomiting. Conclusion: CT scan and MRI imaging modalities are of utmost importance in diagnosing brain tumors. Early diagnosis is important and the imaging guides the neurosurgeon regarding appropriate surgical approach.

Introduction: An internal hernia (IH) is defined as the protrusion of abdominal viscera, most commonly small bowel loops, through a peritoneal or mesenteric aperture into a compartment in the abdominal and pelvic cavity. Usually these patients present with acute abdomen and CT scan becomes the first modality of diagnosis. Aim of the study:To study of role of Computerized Tomography in internal hernias. Materials and Methods: Twelve patients who presented with acute abdomen and having internal hernias on CT scan were studied for the patient demographics, for the type and location of hernia on CT scan. Results: A total of twelve patients were studied. There was slight male predominance and the male to female ratio was 2:1. Majority of patients were among 51-60 years ie, 58.3% followed by 41 to 50 years which had 25% patients. The paraduodenal hernias were most common, accounting for 50% of the cases followed by pericecal hernias that were 16.6% cases. In the present study, twelve cases of internal hernias were diagnosed on CT scan and all correlated well with the intraoperative diagnosis. Conclusion: Clinical diagnosis of internal hernias is often difficult and complicated internal hernias often present as acute intestinal obstruction where urgent diagnosis becomes extremely important. Imaging studies play an important role in the early diagnosis for internal hernias. It is important for the radiologist to recognize these entities so that prompt diagnosis and early intervention can be instituted.

Introduction: Acute pancreatitis is one of the most common diseases of the gastrointestinal tract. Imaging by CT scan helps in diagnosing severity of acute pancreatitis including the presence of pancreatic necrosis as well as local and systemic complications. Current study aimed to study the use of CT scan for the detection and evaluation of acute pancreatitis. Material and Methods: A total of 110 patients diagnosed clinically with acute pancreatitis were studied for patient demographics, clinical presentation, etiology and CT scan findings. Results: A ttal of 110 patients with age ranging from 15 years to 60 years were studied. The male to female ratio was 2.1:1. Most (59%) of the cases were in the 41 to 50 years age. Epigastric pain and vomiting were the most common clinical features. Gall stones and alcoholism were the most common etiological factors for acute pancreatitis. CT findings showed diffuse enlargement in 43.6% cases, and irregular contour in 63.6% cases. Ascites and pleural effusion were noted in 31.8% cases. Balthazar's CTSI system gave better results than the Ranson's criteria. Conclusion: Acute pancreatitis commonly affects adult males. CT scan plays an important role in diagnosing acute pancreatitis and Balthazar's CTSI system is advantageous over the Ranson's criteria system. The CT modality gives information on the severity and extent of the inflammatory process and thereby helps in decision making for patient management.