Physical neglect during childhood alters white matter connectivity in healthy young males

Abstract

PN may have severe consequences and should be considered equally important to more active forms of abuse. FA changes, particularly in the cingulum, actually appear to a functional consequence and are linked to trait anxiety, a personality dimension that is suggested to be a transdiagnostic risk factor of affective disorders. Potentially this reveals a mechanistic chain that forms one pathyway from CA to disease.

The long‐term effects of institutional rearing, foster care intervention and disruptions in care on brain electrical activity in adolescence

“…The immature cortical activity may be the result of deficits in the structural and functional development of the brain. Previous studies have reported that institutional rearing and adversity in early life lead to a reduction in cortical thickness (Kelly et al, ; McLaughlin et al, ), decreased white matter volume (Sheridan, Fox, Zeanah, McLaughlin, & Nelson, ) and white matter connectivity (Tendolkar, Mårtensson, Kühn, Klumpers, & Fernández, ). Sheridan et al () used structural MRI to examine brain structure and function in the CAUG, FCG and NIG from the BEIP cohort between the ages of 8 and 11 years.…”

Nonsocial and social cognition in schizophrenia: current evidence and future directions

“…Childhood adversity – such as physical and/or emotional neglect/abuse, poverty, malnutrition, traumatic experience – can have long‐lasting negative consequences. It affects the development of the brain, such that individuals show both structural and functional cerebral abnormalities during adulthood. Because childhood adversity is also associated with increased risk for developing severe mental illnesses, including schizophrenia, it has been suggested that it could contribute to features of this disorder, including cognitive impairment.…”

Childhood trauma is predictive for clinical staging, alcohol consumption, and emotional symptoms in patients with head and neck cancer

“…Childhood trauma has been pointed out as a predictive psychological event of anxiety in patients with cancer and in noncancer populations. 54 Another investigation showed that early life stress induced in rodents during the neonatal period through a model that simulated physical neglect increased anxiety-like behavior in adulthood. Physical neglect has also been associated with increased levels of anxiety in woman with breast cancer.…”

“…Childhood trauma has been pointed out as a predictive psychological event of anxiety in patients with cancer and in noncancer populations. 19,[50][51][52][53][54][55] Rehan et al 52 showed that women with severe levels of physical neglect in childhood had a greater chance of displaying an anxiety disorder in comparison with women with mild levels of this type of maltreatment. Physical neglect has also been associated with increased levels of anxiety in woman with breast cancer.…”

“…53 A recent study has revealed that the occurrence of physical neglect in childhood alters brain functions that are linked to trait anxiety in healthy young males. 54 Another investigation showed that early life stress induced in rodents during the neonatal period through a model that simulated physical neglect increased anxiety-like behavior in adulthood. 55 On the basis of our findings, the absence of physical protection, clothing, and food in childhood may stimulate the patient to be more vulnerable to anxiety.…”