Physical performance in relation to preserved ratio impaired spirometry: a cross-sectional study of community-dwelling older Japanese adults

Anami, Kunihiko; Murata, Satoshi; Nakano, Hitoo; Iwase, Hiroaki; Shiraiwa, Kayoko; Abiko, Teppei; Goda, Akio; Horie, Jun

doi:10.1038/s41598-021-96830-6

Cited by 7 publications

(2 citation statements)

References 48 publications

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“…Second, the present outcomes might lack external validity and generalizability due to the study design as a single-center analysis, although the lung functions of the study population were substantially comparable to those of other PRISm cohorts. 3 , 5 , 6 , 14 , 26 Third, we did not have access to prescription data of the study population; it was possible that the increase in the D LCO value was due to BD use. However, long-acting bronchodilators have reportedly been unable to contribute to significant improvements in D LCO .…”

Section: Discussionmentioning

confidence: 99%

The Prognostic Performance of Lung Diffusing Capacity in Preserved Ratio Impaired Spirometry: An Observational Cohort Study

Ogata¹,

Sha²,

Kotetsu³

et al. 2022

COPD

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Purpose Similar to chronic obstructive pulmonary disease (COPD), the diffusing capacity of the lung (D LCO ) might be decreased and associated with poor prognosis in preserved ratio impaired spirometry (PRISm), a clinical entity as a prodromal phase of COPD. The aims of the present study were to evaluate the distributions of D LCO and to assess the association between D LCO and mortality among subjects with PRISm. Patients and Methods We conducted an observational cohort study at the National Hospital Organization Fukuoka National Hospital. We classified the 899 patients ≥ 40 years of age with an assessment of D LCO into five groups based on spirometry: preserved spirometry, PRISm, mild COPD, moderate COPD, and severe/very severe COPD. The prevalence of low D LCO (< 80% per predicted) was compared among the five groups. Using PRISm patients with follow-up data, we further investigated the association of low D LCO with all-cause mortality. Results The prevalence of low D LCO in the PRISm group (58.8%) was significantly higher than that in the preserved-spirometry group (21.8%), the mild-COPD group (23.5%), and the moderate-COPD group (36.0%) (all P < 0.01), and it was comparable to that in the severe/very severe-COPD group (63.2%). The results remained unchanged after adjusting for potential confounders. Among the PRISm subjects, the overall survival rate was significantly lower in the low-D LCO group than in the preserved-D LCO group ( P < 0.01). The multivariable-adjusted hazard ratio (HR) for all-cause mortality was significantly higher in the low-D LCO group than in the preserved-D LCO group (HR = 10.10 (95% confidence interval 2.33–43.89)). Conclusion Diffusing capacity was more impaired in PRISm subjects than in those with preserved spirometry or mild to moderate COPD. Regarding PRISm, low D LCO was a significant risk factor for all-cause mortality. Clinicians should assess D LCO in the management of PRISm to predict the future risk of overall death.

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Section: Discussionmentioning

confidence: 99%

The Prognostic Performance of Lung Diffusing Capacity in Preserved Ratio Impaired Spirometry: An Observational Cohort Study

Ogata¹,

Sha²,

Kotetsu³

et al. 2022

COPD

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“…The pulmonary function tests of this study displayed 18.9% of patients with impaired spirometry values, considering FEV1 <80% and FEV1/FVC ≥70% ( 36 ). Other studies show a similar proportion (17%) of spirometry alterations among COVID-19 survivors ( 37 , 38 ).…”

Section: Discussionmentioning

confidence: 80%

Clinical and functional status of patients with severe COVID-19 pneumonia: an observational study at 2–3 months following discharge

Castillo Sánchez,

Camarasa,

Barbeta Sánchez

et al. 2023

Front. Rehabil. Sci.

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IntroductionCritically ill COVID-19 patients present long-term sequelae that affect their everyday life. This study aimed to describe the clinical and functional status of patients with severe COVID-19 pneumonia at 2–3 months post discharge from a Spanish critical care unit.MethodsWe collected retrospective data from 58 patients admitted to the critical care unit with diagnosis of severe respiratory failure due to COVID-19. Only patients who required invasive (IMV) or noninvasive ventilation (NIV) during their hospital stay were included. The following data were collected 2–3 months after hospital discharge: respiratory signs and symptoms, lung ultrasound (LUS) and diaphragm ultrasound images, blood test analysis, lung function parameters (spirometry and DLCO), exercise capacity (6 min walk test and sit-to-stand test), level of physical activity and health-related quality of life.ResultsWe found clinical symptoms and lung structural alterations in LUS images of 26 patients (48.1%). Those presenting LUS abnormalities had longer length of stay in hospital (p = 0.026), functional alterations in spirometry (p < 0.01) and decreased diaphragm excursion (p = 0.029). No significant alterations were observed in blood test analysis, exercise capacity, level of physical activity and health-related quality of life.ConclusionsA significant part of the patients admitted to a critical care unit continue to present clinical symptoms, pulmonary morphological abnormalities, and lung function alterations 2–3 months post discharge. This study corroborates that assessing the functional status of the survivors is essential to monitor the evolution of pulmonary sequelae.

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Clinical relevance of multiple confirmed preserved ratio impaired spirometry cases in adults

Tanabe¹,

Masuda²,

Shiraishi³

et al. 2022

Respiratory Investigation

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Physical performance in relation to preserved ratio impaired spirometry: a cross-sectional study of community-dwelling older Japanese adults

Cited by 7 publications

References 48 publications

The Prognostic Performance of Lung Diffusing Capacity in Preserved Ratio Impaired Spirometry: An Observational Cohort Study

The Prognostic Performance of Lung Diffusing Capacity in Preserved Ratio Impaired Spirometry: An Observational Cohort Study

Clinical and functional status of patients with severe COVID-19 pneumonia: an observational study at 2–3 months following discharge

Clinical relevance of multiple confirmed preserved ratio impaired spirometry cases in adults

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