Physical Properties and Biocompatibility of Oligochitosan Membrane Film as Wound Dressing

Ujang, Zanariah; Rashid, Ahmad Hazri Abdul; Suboh, Siti Kasmarizawaty; Halim, Ahmad Sukari; Lim, Chin Keong

doi:10.5301/jabfm.5000190

Cited by 14 publications

(14 citation statements)

References 27 publications

(30 reference statements)

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“…Their pilot plant in Sepang (SIRIM incubation centre) is a GMP-compliant facility. Preparation of film was produced as described by Ujang and colleagues (2014-in press) 52 …”

Section: Methodsmentioning

confidence: 99%

Efficacy of chitosan derivative films versus hydrocolloid dressing on superficial wounds

Halim

Nor

Saad

et al. 2018

Journal of Taibah University Medical Sciences

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Objectives Chitosan, the N-deacetylated derivative of chitin, has useful biological properties that promote haemostasis, analgesia, wound healing, and scar reduction; chitosan is bacteriostatic, biocompatible, and biodegradable. This study determined the efficacy of chitosan derivative film as a superficial wound dressing. Methods This multicentre randomised controlled trial included 244 patients, of whom 86 were treated with chitosan derivative film and 84 with hydrocolloid. The percentage of epithelisation, as well as patient comfort, clinical signs, and patient convenience in application and removal of the dressings were assessed. Results The primary outcome of this study was the percentage of epithelisation. Except for race ( p = 0.04), there were no significant differences between groups in sex, age, antibiotic usage, or initial wound size ( p > 0.05). There was no significant difference in the mean epithelisation percentage between groups ( p = 0.29). Patients using chitosan derivative film experienced more pain during removal of dressing than those in the hydrocolloid group ( p = 0.007). The chitosan derivative film group showed less exudate ( p = 0.036) and less odour ( p = 0.024) than the control group. Furthermore, there were no significant differences between groups in terms of adherence, ease of removal, wound drainage, erythema, itchiness, pain, and tenderness. No oedema or localised warmth was observed during the study. Conclusion This study concluded that chitosan derivative film is equivalent to hydrocolloid dressing and can be an option in the management of superficial and abrasion wounds. Clinical trial No. NMRR-11-948-10565.

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“…Their pilot plant in Sepang (SIRIM incubation centre) is a GMP-compliant facility. Preparation of film was produced as described by Ujang and colleagues (2014-in press) 52 …”

Section: Methodsmentioning

confidence: 99%

Efficacy of chitosan derivative films versus hydrocolloid dressing on superficial wounds

Halim

Nor

Saad

et al. 2018

Journal of Taibah University Medical Sciences

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“…[34] The in vitro WVTRs for all designs are as shown in Figure 3C. While these WVTR values are higher than the recommended reported in vitro WVTR to ensure optimal wound healing (2500 g d −1 m −2 ), [33] they are still lower than the WVTR of compromised skin. The WVTR values are also not excessively low so as to cause excessive retention of fluids at the wound bed.…”

Section: A Printability Value Less Than 1 Indicates Under Gelation Alongmentioning

confidence: 96%

“…The WVTR for normal human skin is reported to be 204 g d −1 m −2 , and this value can increase up to 5138 g d −1 m −2 for granulating wounds. [33] While a high WVTR is undesirable as it leads to dehydration of the wound, the WVTR should not be too low as well as that will result in the accumulation of wound exudates. [34] The in vitro WVTRs for all designs are as shown in Figure 3C.…”

Section: A Printability Value Less Than 1 Indicates Under Gelation Alongmentioning

confidence: 99%

3D Printing Personalized, Photocrosslinkable Hydrogel Wound Dressings for the Treatment of Thermal Burns

Teoh

Mozhi

Sunil

et al. 2021

Adv Funct Materials

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Considering the variations in burns depending on the circumstances that caused them, the need for personalized medicine and care for burn victims is vital to ensure that optimal treatment is provided. With the level of accuracy and customization that 3D printing brings as a technology, there is potential in its use to fabricate wound dressings that can provide better treatment for burn patients, provided that the material of choice has good printability and can be customized while facilitating wound healing. In this study, the versatility of chitosan methacrylate as said material to be used to fabricate customizable wound dressings via 3D printing is investigated. Synthesized chitosan methacrylate is evaluated to be printable, biodegradable, and biocompatible during wound healing. Various drugs relevant to the treatment of burns are then loaded and different multimaterial wound dressing designs containing different dosages are fabricated via 3D printing. The incorporation of said drugs does not significantly affect the printability of chitosan methacrylate, and the incorporation of antimicrobial agents significantly improves its antimicrobial capabilities. Through in vivo models, these variations in wound dressing designs have good wound healing properties and do not cause any adverse effects in the process.

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“…Results from total bleeding and rate of bleeding in rats suggested that topical application of Opticell dressing with chitosan could be an available method in controlling bleeding correlated with wound debridement. COS was also used to design membrane films by blending various concentrations of glycerol with COS, where the membrane film exhibited high water vapor transmission rates and water absorption capacity thus could be applied to wound-dressing materials [123]. Decanoic acid grafted oligochitosan nanoparticles (CSO-DA NPs) was designed to explore its potential as a carrier for insulin.…”

Section: Biological Functions Of Cosmentioning

confidence: 99%

A Review of the Preparation, Analysis and Biological Functions of Chitooligosaccharide

Liang

Sun

Dai

2018

IJMS

126

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Chitooligosaccharide (COS), which is acknowledged for possessing multiple functions, is a kind of low-molecular-weight polymer prepared by degrading chitosan via enzymatic, chemical methods, etc. COS has comprehensive applications in various fields including food, agriculture, pharmacy, clinical therapy, and environmental industries. Besides having excellent properties such as biodegradability, biocompatibility, adsorptive abilities and non-toxicity like chitin and chitosan, COS has better solubility. In addition, COS has strong biological functions including anti-inflammatory, antitumor, immunomodulatory, neuroprotective effects, etc. The present paper has summarized the preparation methods, analytical techniques and biological functions to provide an overall understanding of the application of COS.

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Physical Properties and Biocompatibility of Oligochitosan Membrane Film as Wound Dressing

Abstract: These results indicate that the membrane film from O-C has potential application as a wound-dressing material.

Cited by 14 publications

References 27 publications

Efficacy of chitosan derivative films versus hydrocolloid dressing on superficial wounds

Efficacy of chitosan derivative films versus hydrocolloid dressing on superficial wounds

3D Printing Personalized, Photocrosslinkable Hydrogel Wound Dressings for the Treatment of Thermal Burns

A Review of the Preparation, Analysis and Biological Functions of Chitooligosaccharide

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