Physical properties, ligand substitution reactions, and biological activity of Co(iii)-Schiff base complexes

Abstract

A subset of fluorinated Co(iii) Schiff base complexes was synthesized, and their structural, ligand exchange, and anticancer properties were investigated.

Metal complexes as a promising source for new antibiotics

“…The axial ligands of 21 and 22 are known to be labile and are likely to undergo substitution reactions in vitro as well. 35 Similarly, the chlorido and 1,3,5triaza-7-phosphaadamantane (PTA) ligands in complexes 10-15 are prone to substitution. 36 Ligand exchanges are conceivable for 23-25 but the biological behavior of these types of compounds has not been studied extensively yet.…”

“…A detailed account on the physical properties and ligand substitution reactions of these complexes was recently published. 35 These compounds also represent the only entries for this structure class so further studies will be needed to elucidate the full potential of these cobalt-based derivatives.…”

Nontoxic Cobalt(III) Schiff Base Complexes with Broad‐Spectrum Antifungal Activity

“…Of note, complex 1 displayed no anticancer activity up to 500 μM while 2 showed high activity against cervical cancer HeLa (IC 50 =7.4±2.4 μM) and A549 lung cancer cell lines (IC 50 =12±1.4 μM) under normoxic conditions, but no activity (up to 250 μM) was observed against MRC‐5 normal lung fibroblasts, a noncancerous cell line [25a] . Complex 4 possessed an IC 50 of 60±17 μM against A549 cells and a high cellular uptake was observed by ICP‐MS [25b] . In our CO‐ADD screening, using broth microdilution (BMD) MIC assays (Table S2), complexes 1 – 3 were effective at killing drug‐susceptible yeast reference strains of C. albicans and C. neoformans while displaying no antibacterial activity.…”

“…Complexes bearing strongly donating equatorial ligands, such as the bis(thiosemicarbazones), undergo rapid axial ligand substitution, with substantial reactivity observed within minutes at 37 °C [25a] . By contrast, complexes with more weakly donating equatorial ligands, such as L2 (Figure 3), are inert toward ligand substitution, with half lives of several hours toward substitution by N ‐methylimidazole at 37 °C [25b] . The properties of the axial ligands are also important, as more strongly donating axial ligands, such as ammonia have longer half‐lives than weak or sterically hindered axial donors, such as benzylamine.…”

Synthesis, structural determination, in vitro and in silico biological evaluation of divalent or trivalent cobalt complexes with indomethacin

“…In 1952, the first reported studies regarding the biological activity of cobalt complexes examined the toxicity of the optical isomers of [Co(en) 3 ](NO 3 ) 3 (en = ethylenediamine) [ 3 ]. Since then, many cobalt complexes of biological interest have been reported with the majority of them showing antiproliferative [ [4] , [5] , [6] , [7] ], antimicrobial [ [8] , [9] , [10] ], antifungal [ 11 , 12 ], antiviral [ 13 , 14 ], and antioxidant [ [15] , [16] , [17] ] activity.…”