Physical structures of Tn10-promoted deletions and inversions: Role of 1400 bp inverted repetitions

Ross, Donald G.; Swan, Judith; Kleckner, Nancy

doi:10.1016/0092-8674(79)90088-6

Cited by 87 publications

(37 citation statements)

References 23 publications

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“…Note that similar effects are also known to occur by homologous recombination between two inverted or directly repeated IS copies in a replicon. Other known mechanisms such as cut-and-paste, or Copy out-Paste in (donor primed transposon replication) (34) would not generate this type of genomic rearrangement but could contribute to genomic modifications in other ways such as "nearly precise excision" (123,124) or by using alternative sequences that resemble their IR (125,126). …”

Section: Influence Of Transposition Mechanismsmentioning

confidence: 99%

Everyman's Guide to Bacterial Insertion Sequences

et al. 2015

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The number and diversity of known prokaryotic insertion sequences (IS) have increased enormously since their discovery in the late 1960s. At present the sequences of more than 4000 different IS have been deposited in the specialized ISfinder database. Over time it has become increasingly apparent that they are important actors in the evolution of their host genomes and are involved in sequestering, transmitting, mutating and activating genes, and in the rearrangement of both plasmids and chromosomes. This review presents an overview of our current understanding of these transposable elements (TE), their organization and their transposition mechanism as well as their distribution and genomic impact. In spite of their diversity, they share only a very limited number of transposition mechanisms which we outline here. Prokaryotic IS are but one example of a variety of diverse TE which are being revealed due to the advent of extensive genome sequencing projects. A major conclusion from sequence comparisons of various TE is that frontiers between the different types are becoming less clear. We detail these receding frontiers between different IS-related TE. Several, more specialized chapters in this volume include additional detailed information concerning a number of these.In a second section of the review, we provide a detailed description of the expanding variety of IS, which we have divided into families for convenience. Our perception of these families continues to evolve and families emerge regularly as more IS are identified. This section is designed as an aid and a source of information for consultation by interested specialist readers.

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Section: Influence Of Transposition Mechanismsmentioning

confidence: 99%

Everyman's Guide to Bacterial Insertion Sequences

et al. 2015

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“…In contrast, most DNA elements move by a "cut and paste" mechanism. Although DNA elements are less abundant compared with retroelements, they can lead to a variety of genome structural changes (Ross et al 1979;Gray 2000;Watanabe et al 2007;Huang and Dooner 2008) including large chromosomal rearrangements, which may contribute to genome evolution (McClintock 1951;McClintock 1978;Lister et al 1993;Zhang et al 2009). …”

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Genome Rearrangements in Maize Induced by Alternative Transposition of ReversedAc/DsTermini

Yu¹,

Zhang

Peterson

2011

Genetics

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Alternative transposition can induce genome rearrangements, including deletions, inverted duplications, inversions, and translocations. To investigate the types and frequency of the rearrangements elicited by a pair of reversed Ac/Ds termini, we isolated and analyzed 100 new mutant alleles derived from two parental alleles that both contain an intact Ac and a fractured Ac ( fAc) structure at the maize p1 locus. Mutants were characterized by PCR and sequencing; the results show that nearly 90% (89/100) of the mutant alleles represent structural rearrangements including deletions, inversions, translocations, or rearrangement of the intertransposon sequence (ITS). Among 37 deletions obtained, 20 extend into the external flanking sequences, while 17 delete portions of the intertransposon sequence. Interestingly, one deletion allele that contains only a single nucleotide between the retained Ac and fAc termini is not competent for further alternative transposition events. We propose a new model for the formation of intertransposon deletions through insertion of reversed transposon termini into sister-chromatid sequences. These results document the types and frequencies of genome rearrangements induced by alternative transposition of reversed Ac/Ds termini in maize.

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“…They have been studied only in IS1 (Reif and Saedler 1975), or in TnlO (Ross et al 1979), but their systems involve deletions on chromosome or on phage genome, and had restrictions in their analysis. Positive selection of deletion occurring on plasmid DNA has been difficult.…”

Section: Discussionmentioning

confidence: 99%

Deletion caused by Tn3: Correlation between deletion and transposition.

Sugino

Kawashima

1983

The Japanese journal of genetics

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A convenient system for detection of deletion formation in the DNA containing Tn3 is described. EcoRI-D fragment containing the kil gene and the c1857 gene of AcI857S7 DNA was ligated into pYS1 (a colicin El like plasmid) containing Tn3. Bacteria harboring these plasmids were temperature sensitive due to induction of the kil gene of phage A at high temperature.Survivors from these bacteria at 42°C have plasmids that have lost the kil gene activity by deletion. In certain mutants in Tn3 which we isolated, such deletion was not detected, nor was Tn3 transposition.On the other hand, in another mutant, in which BamHI site located in tnpR gene in Tn3 was eliminated , the frequency of deletion formation was enhanced, while transposition was normal. From these results, deletion can be considered to be a partial reaction of transposition.

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Physical structures of Tn10-promoted deletions and inversions: Role of 1400 bp inverted repetitions

Cited by 87 publications

References 23 publications

Everyman's Guide to Bacterial Insertion Sequences

Everyman's Guide to Bacterial Insertion Sequences

Genome Rearrangements in Maize Induced by Alternative Transposition of ReversedAc/DsTermini

Deletion caused by Tn3: Correlation between deletion and transposition.

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