Physically Blended and Chemically Modified Polyurethane Hybrid Nanocoatings Using Polyhedral Oligomeric Silsesquioxane Nano Building Blocks: Surface Studies and Biocompatibility Evaluations

Abstract

Organic-inorganic hybrids are promising materials to use as surface coating. Novel types of hybrids coatings containing polyhedral oligomeric silsesquioxane (POSS) have found interests due to their effects on surface properties. In this study, two types of POSS were added to a two-component polyurethane coating either by physical mixing or chemical linking between POSS and matrix and the affection on the surface properties was investigated. Results showed that addition of an open cage POSS by physical mixing caused segregation of POSS at the surface, while by addition of a POSS containing hydroxyl functional group, it distributed in bulk and surface uniformly. POSS existence on the surface was approved by atomic force microscopy and scanning electron microscopy equipped with energy dispersive X-ray technique. Contact angle measurements showed that the surface free energy of the films decreased from 35.3 mJ/m 2 for polyurethane to 13.73 and 11.39 mJ/m 2 for chemically and physically processed films, respectively. Biocompatibility of the blank polyurethane and hybrid materials were studied by an MTT assay. Results revealed that cells prefer to have interface with the surface of physically mixed POSS with the matrix in comparison with chemically added POSS.

Silsesquioxane‐Containing Hybrid Nanomaterials: Fascinating Platforms for Advanced Applications

“…More recently, POSSs have been applied as the components of ophthalmic biomedical devices, such as intraocular lenses or contact lenses, because of their chemical inertness and transparency . By simple physically mixing, nanocomposites from trisilanolisooctyl POSS (open‐cage POSS) hybridizing with PU showed good biocompatibility because of its inert and low inflammatory response …”

“…trisilanolisooctyl POSS (open-cage POSS) hybridizing with PU showed good biocompatibility because of its inert and low inflammatory response. [163] A PU/POSS nanocomposite was fabricated by the Seifalian group by integrating trans-cyclohexanechloroydrinisobutyl-POSS nanoparticles into the poly(ε-caprolactone urea) urethane backbone. The degradation kinetics of this POSS-contained nanocomposite was studied for tissue engineering.…”

Evaluation of the Mechanical Properties and Blood Compatibility of Polycarbonate Urethane and Fluorescent Self-Colored Polycarbonate Urethane as Polymeric Biomaterials

“…Biocompatibility of the materials includes tissue compatibility (histocompatibility) and blood compatibility (hemocompatibility) and since, biomaterials are usually in contact with blood, besides biocompatibility, their blood compatibility is key factor in design and synthesis of polymeric biomaterials for applications such as cardiovascular tissue engineering [5,8,9,[13][14][15][16][17]. Contact of blood with foreign material causes interfacial adsorption of the proteins, which can lead to formation of aggregation, platelet, coagulation, and clots [2,5,18].…”

Development of electrically conductive hybrid nanofibers based on CNT‐polyurethane nanocomposite for cardiac tissue engineering

“…It has a wide range of physicochemical, mechanical, and thermal properties (Guan, Fujimoto, Sacks, & Wagner, ; Kucinska‐Lipka, Gubanska, Janik, & Sienkiewicz, ). To increase cytocompatibility and hemocompatibility, we have previously developed of the surface modified PU nanofibers with VEGF and heparin (Davoudi et al, ), PU/silica composites (Rashti et al, ), POMS/PU nanocomposites (Yahyaei, Mohseni, & Ghanbari, ), and the new polyurethane modified with biomacromolecules (Asadpour, Yeganeh, Ai, & Ghanbari, ), ferulic acid (Asadpour et al, ) and PCL (Asadpour et al, ) for cardiovascular applications.…”